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BDKRB2

  • Official Full Name

    bradykinin receptor B2

  • Overview

    This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
  • Synonyms

    BDKRB2; bradykinin receptor B2; B2R; BK2; BK-2; BKR2; BRB2; B2 bradykinin receptor; BK-2 receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cavia porcellus (Guinea pig)
  • Chicken
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BDKRB2-186H Recombinant Human BDKRB2 Protein, GST-tagged Wheat Germ GST
Human BDKRB2-185H Recombinant Human BDKRB2 Protein, GST-tagged Wheat Germ GST
Human BDKRB2-155H Recombinant Human BDKRB2 Mammalian Cell His
Human BDKRB2-309H Recombinant Human BDKRB2 Protein, His&GST-tagged E.coli N-His&GST Met1-Gln391
Human BDKRB2-1565HF Recombinant Full Length Human BDKRB2 Protein, GST-tagged In Vitro Cell Free System GST 391 amino acids
Human BDKRB2-2540H Recombinant Human BDKRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BDKRB2-038H Recombinant Human BDKRB2 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human BDKRB2-2540H-B Recombinant Human BDKRB2 Protein Pre-coupled Magnetic Beads HEK293
Cavia porcellus (Guinea pig) RFL11513CF Recombinant Full Length Guinea Pig B2 Bradykinin Receptor(Bdkrb2) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Cynomolgus Monkey BDKRB2-341C Recombinant Cynomolgus BDKRB2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey BDKRB2-89C-B Recombinant Cynomolgus Monkey BDKRB2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey BDKRB2-89C Recombinant Cynomolgus Monkey BDKRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL17235HF Recombinant Full Length Human B2 Bradykinin Receptor(Bdkrb2) Protein, His-Tagged E.coli expression system His Full Length (1-391)
Mus musculus (Mouse) RFL28403MF Recombinant Full Length Mouse B2 Bradykinin Receptor(Bdkrb2) Protein, His-Tagged E.coli expression system His Full Length (1-392)
Oryctolagus cuniculus (Rabbit) RFL8845OF Recombinant Full Length Rabbit B2 Bradykinin Receptor(Bdkrb2) Protein, His-Tagged E.coli expression system His Full Length (1-367)
Rattus norvegicus (Rat) RFL6459RF Recombinant Full Length Rat B2 Bradykinin Receptor(Bdkrb2) Protein, His-Tagged E.coli expression system His Full Length (1-396)
Sus scrofa (Pig) RFL2563SF Recombinant Full Length Pig B2 Bradykinin Receptor(Bdkrb2) Protein, His-Tagged E.coli expression system His Full Length (1-367)
Chicken BDKRB2-3197C Recombinant Chicken BDKRB2 Mammalian Cell His
Kit-0868 S-Glutathionylated Protein Detection Kit N/A
Kit-1128 BDKRB2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BDKRB2 Related Articles
  • BDKRB2 Related Research Area

BDKRB2 involved in several pathways and played different roles in them. We selected most pathways BDKRB2 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BDKRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayCALM2;CALM4;GRIN1;PHKA1;RYR1;PDGFRB;SLC8A4A;CALM2B;SLC8A2B
cGMP-PKG signaling pathwayITPR3;BNP;SLC8A1;Adcy4;LOC100328615;PIK3CA;MAPK3;VDAC1;ATP2A3
Sphingolipid signaling pathwaySPTLC2;GNAQ;CERS5;GAB2;BCL2;GNAI3;SPTLC3;MAPK10;CERS4
Neuroactive ligand-receptor interactionDRD4A;TAAR7A;CHRNA4;PTGFR;HTR1B;EDNRAA;BDKRB1;GRIA4A;MCHR2
Complement and coagulation cascadesCD46;F13B;MASP1;C1RA;C4BPA;C3AR1;C9;VWF;C6
Inflammatory mediator regulation of TRP channelsPLCB3;PIK3CB;CYP2C38;PLCB1;NTRK1;ASIC1;PRKACA;CYP2C55;PRKCB
Regulation of actin cytoskeletonMRAS;PPP1CAB;ITGB1B.2;ARPC5B;PIP5K1BA;VCL;MAP2K2B;Pdgfa&Pdgfb;PDGFAA
Endocrine and other factor-regulated calcium reabsorptionBDKRB2;GNAQ;GNAS;ATP1B1;ESR1;SLC8A1;KLK1B3;ATP1A3;ATP1B2
Chagas disease (American trypanosomiasis)IL10;PLCB1;CD247;MAPK13;PPP2R2C;C1QC;GNA15;TLR9;GNAI2
Pathways in cancerFZD10;RAC2;IL6;FGF4;SMAD4;GLI3;NOS2;PLCB3;WNT5A

BDKRB2 has several biochemical functions, for example, beta-2 adrenergic receptor binding, bradykinin receptor activity, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BDKRB2 itself. We selected most functions BDKRB2 had, and list some proteins which have the same functions with BDKRB2. You can find most of the proteins on our site.

Function Related Protein
beta-2 adrenergic receptor bindingSLC9A3R1;NEDD4;GNAS;PDE4D;BDKRB2
bradykinin receptor activityBDKRB1;BDKRB2
phosphatidylinositol phospholipase C activityCCR5;PLCB2;PLCB3;PLCD3A;CCKBR;PLCB1;PLCB4;PLCD1;PLCL1
protease bindingUBC;SRI;CSTA;BDKRB2;TIMP1;STIM1;TNFAIP3;LRP1;CRADD
protein bindingHENMT1;TMEM25;SEPT5;C1orf216;CD93;PKM;INTS10;SMIM3;CDH5
protein heterodimerization activityHOMER2;SNX6;APITD1;H2AFZ;TAF9;TRP53;MAFA;HIST1H2AC;SYT5
type 1 angiotensin receptor bindingTYK2;GNA13A;GNB1;GNA13;AGT;ARRB2;GNG3;JAK2;ARAP1

BDKRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BDKRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BDKRB2.

npc-567; KNG1

Veljkovic, V; Glisic, S; et al. Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism. VACCINE 32:6569-6575(2014).
Marketou, ME; Kontaraki, J; et al. Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension. JOURNAL OF HUMAN HYPERTENSION 28:450-455(2014).
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