BDKRB2
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Official Full Name
bradykinin receptor B2
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Overview
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008] -
Synonyms
BDKRB2; bradykinin receptor B2; B2R; BK2; BK-2; BKR2; BRB2; B2 bradykinin receptor; BK-2 receptor;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cavia porcellus (Guinea pig)
- Chicken
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BDKRB2 Related Articles
- BDKRB2 Related Research Area
BDKRB2 involved in several pathways and played different roles in them. We selected most pathways BDKRB2 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BDKRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | HTR2B;ITPKB;PLCD4;CHRM5A;AKR1C1;STIM1A;CACNA1G;TNNC2;CAMK2B1 |
| cGMP-PKG signaling pathway | Adcy4;PIK3R1;ATP1B3;PPP1R12A;PIK3R5;ITPR1;GTF2I;ITPR3;SLC25A31 |
| Sphingolipid signaling pathway | PLCB2;NRAS;ROCK1;PLCB3;LOC100328615;RAF1;PPP2CB;RAC3;AKT1 |
| Neuroactive ligand-receptor interaction | CHRND;TAAR12C;TSPO;S1PR2;GRIN1A;ADRB2A;TACR3;TAAR8B;F2 |
| Complement and coagulation cascades | SERPINA1A;C5;FGB;KNG1;CFD;C1QC;C1QA;F13B;SERPINC1 |
| Inflammatory mediator regulation of TRP channels | PLCG1;GNAS;MAP2K3;PPP1CA;CYP2C70;PIK3CA;TRPA1;KLK1B4;PIK3R2 |
| Regulation of actin cytoskeleton | ITGB8;FGFR3;ITGB2L;PAK2A;ROCK2;PFN4;ARHGEF7A;PFN2L;MYLK4 |
| Endocrine and other factor-regulated calcium reabsorption | ATP1A1;ATP1B4;ATP1A3;KLK1B9;ATP1B3;KLK1B5;TRPV5;DNM2;RAB11A |
| Chagas disease (American trypanosomiasis) | PPP2R2B;GNAQ;Fasl;LOC100033925;IL12B;CXCL8;TRAF6;AKT1;CD247 |
| Pathways in cancer | BRAF;FH;IL6;NTRK1;CCDC6;MAPK10;CUL2;MDM2;FN1 |
BDKRB2 has several biochemical functions, for example, beta-2 adrenergic receptor binding, bradykinin receptor activity, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BDKRB2 itself. We selected most functions BDKRB2 had, and list some proteins which have the same functions with BDKRB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-2 adrenergic receptor binding | PDE4D;GNAS;SLC9A3R1;NEDD4;BDKRB2 |
| bradykinin receptor activity | BDKRB2;BDKRB1 |
| phosphatidylinositol phospholipase C activity | CASR;CHRM5;PLD4;CCL5;PLCD1;PLCD1B;PLCH2;PLCD3A;BDKRB2 |
| protease binding | CCDC71L;PYCARD;SEMG2;Serpina1c;TIMP2;NFRKB;KIT;SERPINA1;OS9 |
| protein binding | CFH;POLR3C;JPH2;CD44;AGRN;FABP1;MORF4L1;LINC01588;SSX2IP |
| protein heterodimerization activity | SIM2;IL12A;SOX17;TYR;TAF6;JAM2A;MYF6;OSTB;ZHX1 |
| type 1 angiotensin receptor binding | GNA13B;ARAP1;GNA13A;JAK2;AGT;GNB1;BDKRB2;TYK2;ARRB2 |
BDKRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BDKRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BDKRB2.
npc-567; KNG1
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