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BEST3

Official Full Name

bestrophin 3
Overview

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in;vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM;607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of;aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene;structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron;boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 (PubMed;12032738); Tsunenari et al., 2003 (PubMed 12907679)).
Synonyms

BEST3; bestrophin 3; vitelliform macular dystrophy 2 like 3 , VMD2L3; bestrophin-3; MGC13168; MGC40411; Vitelliform macular dystrophy 2 like protein 3; BEST 3; BEST3_HUMAN; Bestrophin3; OTTHUMP00000195114; OTTHUMP00000233491; Vitelliform macular dystrophy 2 like 3; Vitelliform macular dystrophy 2-like protein 3; VMD2L3; vitelliform macular dystrophy 2-like 3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)

Source

E.coli
E.coli expression system
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BEST3-10209H	Recombinant Human BEST3, His-tagged	E.coli	His	C-term-186a.a.	$319 / 25ug
Human	BEST3-8466HCL	Recombinant Human BEST3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	BEST3-3094H	Recombinant Human BEST3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	BEST3-2378M	Recombinant Mouse BEST3 Protein	Mammalian Cell	His		Inquiry
Mouse	Best3-1860M	Recombinant Mouse Best3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Best3-313M	Recombinant Mouse Best3 Protein, His&GST-tagged	E.coli	N-His&GST	Glu507-Phe669	Inquiry
Mouse	BEST3-1014M	Recombinant Mouse BEST3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	BEST3-1014M-B	Recombinant Mouse BEST3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL34325HF	Recombinant Full Length Human Bestrophin-3(Best3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-668)	Inquiry
Mus musculus (Mouse)	RFL10127MF	Recombinant Full Length Mouse Bestrophin-3(Best3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-669)	Inquiry
Chicken	BEST3-4453C	Recombinant Chicken BEST3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

BEST3 involved in several pathways and played different roles in them. We selected most pathways BEST3 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with BEST3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ion channel transport	ATP2C2;WNK1;ATP10A;TPCN1;ANO10A;CLCN7;ANO5;TRPA1B;ATP2C1
Stimuli-sensing channels	ANO5B;TRPA1A;TTYH3B;TRPA1B;TRPC5;TRPC4APB;GSDMA2;BEST3;SLC17A3
Transmembrane transport of small molecules	ABCC9;SLC4A3;SLC39A1;ABCG4B;BEST1;SLC4A4A;MIP;SLC43A2B;SLCO2A1

BEST3 has several biochemical functions, for example, contributes_to chloride channel activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by BEST3 itself. We selected most functions BEST3 had, and list some proteins which have the same functions with BEST3. You can find most of the proteins on our site.

Function	Related Protein
contributes_to chloride channel activity	GABRR2;BEST2;GABRZ;GABRR2A;GABRQ;BSND;GABRB3;GABRR3A;BEST4
molecular_function	FHDC1;COMMD4;COL9A1A;Atp5g2;TMEM132A;NKX2-4;ZFP474;TDPOZ3;GM14692

BEST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BEST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BEST3.