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BEST4

  • Official Full Name

    bestrophin 4

  • Overview

    This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3 ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon.
  • Synonyms

    BEST4; bestrophin 4; vitelliform macular dystrophy 2 like 2 , VMD2L2; bestrophin-4; BEST 4; Bestrophin4; MGC126872; Vitelliform macular dystrophy 2 like 2; Vitelliform macular dystrophy 2 like protein 2; VMD2L2; vitelliform macular dystrophy 2-like 2; vitelliform macular dystrophy 2-like protein 2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BEST4-10210H Recombinant Human BEST4, His-tagged E.coli His 95-473a.a.
Human BEST4-0748H Recombinant Human BEST4 Protein (Ile242-Met384), N-His tagged E.coli N-His Ile242-Met384
Homo sapiens (Human) RFL31636HF Recombinant Full Length Human Bestrophin-4(Best4) Protein, His-Tagged E.coli expression system His Full Length (1-473)
Chicken BEST4-4546C Recombinant Chicken BEST4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

BEST4 involved in several pathways and played different roles in them. We selected most pathways BEST4 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with BEST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportANO7;ANO5;FKBP1B;ATP13A1;ATP2B3A;ASPH;CLCN2;TTYH1;FXYD7
Stimuli-sensing channelsCLCN1;CLCN4;TRPV3;ANO10A;TRPM4A;TRPC4B;TRPA1B;TTYH2;WNK1
Transmembrane transport of small moleculesSLC43A1A;PDZD11;LCN9;SLC38A4;SLC9A7;SLC4A8;SLC39A3;NHEDC1;SLC20A1

BEST4 has several biochemical functions, for example, contributes_to chloride channel activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by BEST4 itself. We selected most functions BEST4 had, and list some proteins which have the same functions with BEST4. You can find most of the proteins on our site.

Function Related Protein
contributes_to chloride channel activityGABRB1;BEST2;GABRR2;GABRB3;GABRR2A;GABRR3A;GABRZ;GABRQ;BEST3
molecular_functionCCDC85AL;HEATR5A;GM10670;GGA1;ACSM2B;SYCE1L;FAM73A;DEPDC7;TNNI2A.4

BEST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BEST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of BEST4.

Dlg4

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