birc8
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  • Official Full Name
  • baculoviral IAP repeat containing 8
  • Background
  • Protects against apoptosis mediated by BAX.
  • Synonyms
  • BIRC8; baculoviral IAP repeat containing 8; ILP2; ILP-2; hILP2; baculoviral IAP repeat-containing protein 8; IAP-like protein 2; baculoviral IAP repeat-containing 8; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis;
Cat.#:BIRC8-10235HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BIRC8, GST-tagged
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Cat.#:BIRC8-233HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BIRC8 Protein, GST-tagged
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Cat.#:BIRC8-234HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BIRC8 Protein, GST-tagged
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Cat.#:BIRC8-171HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BIRC8 cell lysate
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Involved Pathway

BIRC8 involved in several pathways and played different roles in them. We selected most pathways BIRC8 participated on our site, such as Apoptosis, Pathways in cancer, Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
NFKBIAA; HIST1H1E; DIABLOA; PPP3R2; BAX; AKT2; PLEC; DSG1; ATM; CTNNB1
Pathways in cancer
GNAI1; TFG; PTGER3; ARHGEF12; PRKCA; CCDC6; Pdgfa&Pdgfb; PRKCG; PDGFRB; TCF7L2
Small cell lung cancer
FN1; LAMC1; ITGAV; LAMA2; CCNE1; PIAS2; FHIT; PTGS2; RARB; PIK3CA
Toxoplasmosis
IL12B; PIK3CD; MAPK9; HLA-DRB1; MAPK13; STAT3; IKBKG; LAMA2; MAPK10; LAMB2
Ubiquitin mediated proteolysis
BTRC; UBE2D2; CUL1B; UBE3B; UBE2D2A; MDM2; TCEB2; COP1; UBE2B; CUL3

Protein Function

BIRC8 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ubiquitin-protein transferase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC8 itself. We selected most functions BIRC8 had, and list some proteins which have the same functions with BIRC8. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein IGF1RB; VIL1; CD27; BIRC7; PRDX3; RPS6KA1; MT3; AVP; LEF1; DPEP1
Function ubiquitin-protein transferase activity
Related Protein FBXL3; TRIM32; FBXL7; UBE2O; UBE2G2; UBA1; UBE3C; FBXO11; RNF135; BIRC7
Function zinc ion binding
Related Protein TRIM45; ZNF146; ZNF34; RNF20; PHC1; ZDHHC6; CHD4A; PHF20B; AEBP1; G2E3

Interacting Protein

BIRC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC8.
HIP2; UBE2D1; UBE2E1; UBE2D3; UBE2N; UBE2D2; UBE2V1; UBE2W; UBE2D4

BIRC8 Related Articles

Barathan, M; Gopal, K; et al. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. APOPTOSIS 20:466-480(2015).
Glodkowska-Mrowka, E; Solarska, I; et al. Differential expression of BIRC family genes in chronic myeloid leukaemia-BIRC3 and BIRC8 as potential new candidates to identify disease progression. BRITISH JOURNAL OF HAEMATOLOGY 164:740-742(2014).