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BMX

  • Official Full Name

    BMX non-receptor tyrosine kinase

  • Overview

    This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms

    BMX; BMX non-receptor tyrosine kinase; cytoplasmic tyrosine-protein kinase BMX; ETK; PSCTK3; NTK38 tyrosine kinase; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinase gene in chromosome X protein; PS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • MYC
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BMX-1368H Active Recombinant Human BMX, GST-tagged Sf9 Insect Cell GST Full length
Human BMX-462HFL Active Recombinant Full Length Human BMX Protein, C-Flag-tagged Mammalian cells Flag
Human BMX-27HFL Active Recombinant Full Length Human BMX Protein, N-His-tagged Sf21 His Full Length
Human BMX-26755TH Recombinant Human BMX N/A
Human BMX-37H Recombinant Human BMX protein, Flag-tagged, Biotinylated Insect Cell Flag
Human BMX-654H Recombinant Human BMX Non-receptor Tyrosine Kinase, Active E.coli N/A
Human BMX-290H Recombinant Human BMX Protein, GST-tagged Wheat Germ GST
Human BMX-251H Recombinant Human BMX, GST-tagged, Active Sf9 Insect Cell GST
Human BMX-10259H Recombinant Human BMX, His-tagged E.coli His C-term-300a.a.
Human BMX-8427HCL Recombinant Human BMX 293 Cell Lysate HEK293 N/A
Human BMX-452H Recombinant Human BMX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BMX-0751H Recombinant Human BMX Protein (E411-H675), Tag Free Insect Cell No tag E411-H675
Human BMX-3182H Recombinant Human BMX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BMX-452H-B Recombinant Human BMX Protein Pre-coupled Magnetic Beads HEK293
Human BMX-2737HF Active Recombinant Full Length Human BMX Protein, GST-tagged Insect (sf21) GST 1-675(end)
Human BMX-0752H Recombinant Human BMX Protein (E411-H675), His tagged Insect Cell His E411-H675
Human BMX-5976HF Active Recombinant Full Length Human BMX Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-675(end)
Human BMX-0776H Recombinant Human BMX Protein (Glu287-Gly523), N-His tagged E.coli N-His Glu287-Gly523
Human BMX-4246H Recombinant Human BMX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Bmx-716M Recombinant Mouse Bmx Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Bmx-1530M Recombinant Mouse Bmx protein, His & T7-tagged E.coli His/T7 Gln209~Lys446 (Accession # P97504)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BMX Related Articles
  • BMX Related Research Area

BMX involved in several pathways and played different roles in them. We selected most pathways BMX participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Apoptosis, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Angiopoietin receptor Tie2-mediated signalingCRK;BMX;ELF1;CDKN1A;ELF2;GRB14;AGTR1;DOK2;GRB7
ApoptosisCRADD;E2F1;IRAK3;AIFM1;CASP3B;PRKACG;PPP3CCA;GAS2;TNFRSF1A
Apoptotic cleavage of cellular proteinsPKP1;STK26;CLSPN;CASP6L1;GAS2;STK24;DBNLB;OCLN;BCAP31
Apoptotic execution phaseHIST1H1A;HMGB2A;DFFA;SPNA2;GAS2;DSG1;PANK1A;HIST1H1B;VIML
IL-3 Signaling PathwayCISH;GATA1;PILRB;BIRC5A;GATA1A;GNB2L1;SPI1B;GSK3AB;GATA2
IL-6 Signaling PathwayDAXX;CDK5R1B;BMX;EIF2A
Programmed Cell DeathGZME;DAPK1;PLECA;DBNL;RIPK3;DBNLB;BAXB;DSP;MLKL
Signaling events mediated by focal adhesion kinaseACTA1;KLF8;ARHGEF28;ARHGAP26;BMX

BMX has several biochemical functions, for example, ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMX itself. We selected most functions BMX had, and list some proteins which have the same functions with BMX. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX3Y;DHX37;BMPR1BA;Adcy4;HLCS;ABCD1;ACSBG2;KHK;QARS
metal ion bindingING5A;COL27A1A;LMO4A;ZFP804A;FBXL19;ZFP319;ZBED4;TRMT13;ASXL1
non-membrane spanning protein tyrosine kinase activityPTK2BB;FES;EIF2AK2;BTK;TNK1;PTK2B;LCK;ZNF143B;PTK2AA
protein bindingUQCC2;LAMA4;SNRNP40;PDIA3;HIP1R;ACCS;CDK7;UBXN4;KRT79
protein tyrosine kinase activityEPHB4B;CLK4;TYK2;NEK1;INSRB;MUSK;TYRO3;EGFRA;EPHB3A
NOT receptor bindingTEC;STYK1;BMX;ITK;LGI1;TXK;BTK
signal transducer activityTAS2R144;TAS1R2.2;GNA13A;TAS2R106;OLFR494;RGS11;ADORA2AB;VMN1R49;ADRB2A

BMX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMX here. Most of them are supplied by our site. Hope this information will be useful for your research of BMX.

STAT3; PIM1; PIM1; saicar; EGFR; ERBB2; PKM; TP53; HSP90AB1; CRK; CLNK

Wu, YC; Kai, YH; et al. Persistently betanodavirus-infected barramundi (Lates calcarifer) exhibit resistances to red sea bream iridovirus infection. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 41:666-674(2013).
Cohen, I; Maoz, M; et al. Etk/Bmx Regulates Proteinase-Activated-Receptor1 (PAR(1)) in Breast Cancer Invasion: Signaling Partners, Hierarchy and Physiological Significance. PLOS ONE 5:-(2010).
  • Q&As
  • Reviews

Q&As (7)

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How does BMX interact with other members of the Tec family kinases in immune cell signaling? 04/23/2022

BMX interacts with Tec family kinases to regulate immune cell signaling, affecting immune responses.

What are the effects of BMX inhibition on the angiogenesis process in tumor models? 08/15/2021

Inhibition of BMX reduces angiogenesis in tumor models, suggesting a role in tumor growth and metastasis.

What are the potential therapeutic applications of targeting BMX in cardiovascular diseases? 04/29/2021

Targeting BMX in cardiovascular diseases offers potential therapeutic benefits, possibly impacting vascular remodeling and function.

What are the specific substrates of BMX kinase in different cell types and how do they influence cell signaling pathways? 09/08/2020

BMX kinase substrates vary by cell type, impacting diverse signaling pathways related to cell growth and survival.

How does the expression of BMX vary in normal versus cancerous tissues, particularly in breast and prostate cancers? 08/26/2020

BMX expression differs in cancerous tissues, with heightened levels in certain breast and prostate cancers, indicating a potential role in tumor progression.

What role does BMX play in the regulation of inflammatory responses in autoimmune diseases? 10/28/2018

BMX is involved in regulating inflammatory responses, playing a significant role in autoimmune disease mechanisms.

How does phosphorylation affect the activity and stability of BMX in cellular contexts? 07/03/2018

Phosphorylation alters BMX activity and stability, influencing its function in cellular signaling processes.

Customer Reviews (3)

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Reviews
02/22/2022

    Accurate mass spectrometry analysis; essential for proteomics research.

    10/02/2021

      Reliable western blot results; a staple for our lab work.

      10/15/2018

        Precise protein quantification; vital for our research projects.

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