BMX
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Official Full Name
BMX non-receptor tyrosine kinase
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Overview
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
BMX; BMX non-receptor tyrosine kinase; cytoplasmic tyrosine-protein kinase BMX; ETK; PSCTK3; NTK38 tyrosine kinase; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinase gene in chromosome X protein; PS;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- MYC
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- BMX Related Articles
- BMX Related Research Area
BMX involved in several pathways and played different roles in them. We selected most pathways BMX participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Apoptosis, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Angiopoietin receptor Tie2-mediated signaling | CRK;BMX;ELF1;CDKN1A;ELF2;GRB14;AGTR1;DOK2;GRB7 |
Apoptosis | CRADD;E2F1;IRAK3;AIFM1;CASP3B;PRKACG;PPP3CCA;GAS2;TNFRSF1A |
Apoptotic cleavage of cellular proteins | PKP1;STK26;CLSPN;CASP6L1;GAS2;STK24;DBNLB;OCLN;BCAP31 |
Apoptotic execution phase | HIST1H1A;HMGB2A;DFFA;SPNA2;GAS2;DSG1;PANK1A;HIST1H1B;VIML |
IL-3 Signaling Pathway | CISH;GATA1;PILRB;BIRC5A;GATA1A;GNB2L1;SPI1B;GSK3AB;GATA2 |
IL-6 Signaling Pathway | DAXX;CDK5R1B;BMX;EIF2A |
Programmed Cell Death | GZME;DAPK1;PLECA;DBNL;RIPK3;DBNLB;BAXB;DSP;MLKL |
Signaling events mediated by focal adhesion kinase | ACTA1;KLF8;ARHGEF28;ARHGAP26;BMX |
BMX has several biochemical functions, for example, ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMX itself. We selected most functions BMX had, and list some proteins which have the same functions with BMX. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | DDX3Y;DHX37;BMPR1BA;Adcy4;HLCS;ABCD1;ACSBG2;KHK;QARS |
metal ion binding | ING5A;COL27A1A;LMO4A;ZFP804A;FBXL19;ZFP319;ZBED4;TRMT13;ASXL1 |
non-membrane spanning protein tyrosine kinase activity | PTK2BB;FES;EIF2AK2;BTK;TNK1;PTK2B;LCK;ZNF143B;PTK2AA |
protein binding | UQCC2;LAMA4;SNRNP40;PDIA3;HIP1R;ACCS;CDK7;UBXN4;KRT79 |
protein tyrosine kinase activity | EPHB4B;CLK4;TYK2;NEK1;INSRB;MUSK;TYRO3;EGFRA;EPHB3A |
NOT receptor binding | TEC;STYK1;BMX;ITK;LGI1;TXK;BTK |
signal transducer activity | TAS2R144;TAS1R2.2;GNA13A;TAS2R106;OLFR494;RGS11;ADORA2AB;VMN1R49;ADRB2A |
BMX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMX here. Most of them are supplied by our site. Hope this information will be useful for your research of BMX.
STAT3; PIM1; PIM1; saicar; EGFR; ERBB2; PKM; TP53; HSP90AB1; CRK; CLNK
- Q&As
- Reviews
Q&As (7)
Ask a questionBMX interacts with Tec family kinases to regulate immune cell signaling, affecting immune responses.
Inhibition of BMX reduces angiogenesis in tumor models, suggesting a role in tumor growth and metastasis.
Targeting BMX in cardiovascular diseases offers potential therapeutic benefits, possibly impacting vascular remodeling and function.
BMX kinase substrates vary by cell type, impacting diverse signaling pathways related to cell growth and survival.
BMX expression differs in cancerous tissues, with heightened levels in certain breast and prostate cancers, indicating a potential role in tumor progression.
BMX is involved in regulating inflammatory responses, playing a significant role in autoimmune disease mechanisms.
Phosphorylation alters BMX activity and stability, influencing its function in cellular signaling processes.
Customer Reviews (3)
Write a reviewAccurate mass spectrometry analysis; essential for proteomics research.
Reliable western blot results; a staple for our lab work.
Precise protein quantification; vital for our research projects.
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