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BRF1

  • Official Full Name

    BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit

  • Overview

    This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]
  • Synonyms

    BRF1; BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit; BRF; hBRF; BRF-1; GTF3B; TAF3C; TAF3B2; TF3B90; TAFIII90; TFIIIB90; HEL-S-76p; transcription factor IIIB 90 kDa subunit; B - related factor 1; general transcription factor IIIB, 90kD subunit; TBP - associated factor, RNA polymerase III, 90kD; epididymis secretory sperm binding protein Li 76p; TATA box binding protein (TBP)-associated factor 3C; BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Wheat Germ
  • Yeast
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BRF1-336H Recombinant Human BRF1 Protein, GST-tagged Wheat Germ GST
Human BRF1-180HCL Recombinant Human BRF1 cell lysate N/A
Human BRF1-5844H Recombinant Human BRF1 protein, His-tagged Yeast His 1-677aa
Human BRF1-2791H Recombinant Human BRF1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BRF1-3794HF Recombinant Full Length Human BRF1 Protein, GST-tagged In Vitro Cell Free System GST 208 amino acids
Mouse Brf1-1892M Recombinant Mouse Brf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein

BRF1 involved in several pathways and played different roles in them. We selected most pathways BRF1 participated on our site, such as Gene Expression, Integrated Pancreatic Cancer Pathway, RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionTTC6;ZNF286A;ZNF136;HNRNPH1;ZNF18;BCAS2;EIF4H;NR2E1;CBX3
Integrated Pancreatic Cancer PathwayRAPGEF3;DAXX;JUND;FKBP1B;BRF1;LEFTY1;MAPK4;FKBP3;FST
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionPOU2F1;SNAPC5;GATAD2B;TFB2M;NFIC;GATAD2A;GTF3C4;BRF2;MBD3B
RNA Polymerase III Abortive And Retractive InitiationBRF2;GTF3C5;SNAPC2;SNAPC5;CRCP;SNAPC1;NFIB;GTF3C2;SNAPC4
RNA Polymerase III TranscriptionZNF143A;NFIC;NFIX;GTF3AB;SNAPC4;POLR3GLA;BRF2;GTF3C5;BRF1B
RNA Polymerase III Transcription InitiationSNAPC3;GTF3AA;ZFP143;ZNF143;BRF2;GTF3C5;POLR3GLA;SNAPC1;ZNF143A
RNA Polymerase III Transcription Initiation From Type 1 PromoterGTF3C4;GTF3C3;BRF1;GTF3C5;GTF3AB;GTF3A;GTF3C2;BRF1B;POLR3GLA
RNA Polymerase III Transcription Initiation From Type 2 PromoterGTF3C5;BRF1;GTF3C2;GTF3C3;GTF3C4;BRF1B

BRF1 has several biochemical functions, for example, TBP-class protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRF1 itself. We selected most functions BRF1 had, and list some proteins which have the same functions with BRF1. You can find most of the proteins on our site.

Function Related Protein
TBP-class protein bindingEFCAB11;BRF1;TAF1;PSMC6;BRF1B;PSMC5;BRF1A;TAF1L;PSMC1B
zinc ion bindingFTR67;BRF1A;KDM5D;ZCCHC12;PAPLNB;ADAMTS15A;NPEPPS;PPARAB;ADA

BRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRF1.

TBP; DTNBP1; ACSL4; Eef1a1; Rab5c; Vbp1; Gpsm1; CCDC132; POLR3E; TCF20

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