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BUB1

  • Official Full Name

    BUB1 mitotic checkpoint serine/threonine kinase

  • Overview

    This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • Synonyms

    BUB1; BUB1 mitotic checkpoint serine/threonine kinase; BUB1A; BUB1L; hBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase; budding uninhibited by benzimidazoles 1 homolog; BUB1 budding uninhibited by benzimidazoles 1 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Mammalian Cell
  • Mammalian cells
  • Spodoptera Frugiperda
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BUB1-595H Recombinant Human BUB1 Mammalian Cell His
Human BUB1-400H Recombinant Human BUB1 Protein, GST-tagged Wheat Germ GST
Human BUB1-8383HCL Recombinant Human BUB1 293 Cell Lysate HEK293 N/A
Human BUB1-2408H Recombinant Human BUB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BUB1-2948H Recombinant Human BUB1 protein, His-tagged E.coli His 785-1083 aa
Human BUB1-462H Recombinant Human BUB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BUB1-5059HF Active Recombinant Full Length Human BUB1 Protein, GST-tagged Insect (sf21) GST 1-1085(end)
Human BUB1-1746HFL Recombinant Full Length Human BUB1 Protein, C-Flag-tagged Mammalian cells Flag
Human BUB1-1688HF Recombinant Full Length Human BUB1 Protein, GST-tagged In Vitro Cell Free System GST 1085 amino acids
Human BUB1-462H-B Recombinant Human BUB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bub1-725M Recombinant Mouse Bub1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Chicken BUB1-2088C Recombinant Chicken BUB1 Mammalian Cell His
CBCRY01 Mitotic checkpoint serine/threonine-protein kinase BUB1 Spodoptera Frugiperda N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BUB1 Related Articles

BUB1 involved in several pathways and played different roles in them. We selected most pathways BUB1 participated on our site, such as Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with BUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleGINS2;RAD21;YWHABL;CCP110;TEX12;NIPBLA;NCAPH2;TP53BP1;TUBGCP3
Oocyte meiosisINS1;CPEB1B;CALM1;PPP2R5C;YWHABL;CCNB2;SGOL1;RPS6KA2;PPP2R5A
Progesterone-mediated oocyte maturationCPEB1A;PIK3CB;GNAI2B;CPEB2;CCNA1;PIK3CA;PRKACBB;INS;PDE3B

BUB1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by BUB1 itself. We selected most functions BUB1 had, and list some proteins which have the same functions with BUB1. You can find most of the proteins on our site.

Function Related Protein

BUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BUB1.

Pickhard, A; Grober, S; et al. Survivin and pAkt as potential prognostic markers in squamous cell carcinoma of the head and neck. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 117:733-742(2014).
Santana, A; Vicente-Salar, N; et al. LIF Insensitivity and Expression of Proteins Activated by DNA Damage Response in Teratoma-Isolated Cells Derived from Mouse Embryonic Stem Cells. CYTOLOGIA 78:195-202(2013).
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