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BACH1

  • Official Full Name

    BTB and CNC homology 1, basic leucine zipper transcription factor 1

  • Overview

    This gene encodes a transcription factor that belongs to the capncollar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
  • Synonyms

    BACH1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; transcription regulator protein BACH1; BACH 1; HA2303; BTB and CNC homolog 1; basic region leucine zipper transcriptional regulator BACH1; BACH-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BACH1-27427TH Recombinant Human BACH1 Wheat Germ N/A 108 amino acids
Human BACH1-044H Recombinant Human BACH1 protein, GST-tagged Wheat Germ GST
Human BACH1-8532HCL Recombinant Human BACH1 293 Cell Lysate HEK293 N/A
Human BACH1-8531HCL Recombinant Human BACH1 293 Cell Lysate HEK293 N/A
Human BACH1-3374H Recombinant Human BACH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BACH1-4068H Recombinant Human BACH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BACH1-22H Recombinant Human BACH1 Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human BACH1-001H Recombinant Human BACH1 Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human BACH1-1764HF Recombinant Full Length Human BACH1 Protein, GST-tagged In Vitro Cell Free System GST 736 amino acids
Human BACH1-736HFL Recombinant Full Length Human BACH1 Protein, C-Flag-tagged Mammalian cells Flag
Human BACH1-254HFL Recombinant Full Length Human BACH1 Protein, C-Flag-tagged Mammalian cells Flag
Human BACH1-27427H Recombinant Human BACH1 Protein, GST-tagged Wheat Germ GST 396-492
Human BACH1-416H Recombinant Human BACH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BACH1-416H-B Recombinant Human BACH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse BACH1-2267M Recombinant Mouse BACH1 Protein Mammalian Cell His
Mouse BACH1-948M Recombinant Mouse BACH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BACH1-948M-B Recombinant Mouse BACH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bach1-687M Recombinant Mouse Bach1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque BACH1-504R Recombinant Rhesus monkey BACH1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BACH1-332R-B Recombinant Rhesus Macaque BACH1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BACH1-332R Recombinant Rhesus Macaque BACH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BACH1 Related Articles

BACH1 involved in several pathways and played different roles in them. We selected most pathways BACH1 participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BACH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Integrated Breast Cancer PathwayAPOBEC3G;CYP19A1;USP15;LGALS13;CCNB1IP1;BACH1;NAB1;ERAL1;C21orf7

BACH1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, heme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BACH1 itself. We selected most functions BACH1 had, and list some proteins which have the same functions with BACH1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II distal enhancer sequence-specific DNA bindingMIXL1;RXRB;ARX;CDX2;PROP1;MED12;H3F3A;PBX3;RUVBL2
heme bindingHRG;PTGS2A;CYP2AD2;CYP2D6;CYP2R1;NOS3;CYP19A1A;CYP2C8;SRC
protein bindingGGN;CSNK1G2;MOB4;IFIT3;DCUN1D5;ARL6IP4;KCNJ5;NAA38;NRP1B
transcription factor activity, sequence-specific DNA bindingHNF1B;HMGB2;SIM2;ZSCAN23;ZNF311;ZXDC;ZGPAT;TEFA;INSM1A
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingPROP1;TARDBP;FUBP1;FOXH1;HCFC1;SIX3;MEOX2;POU4F1;HMGA1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingHOXA2;PROX1;KLF16;SALL1;ZGPAT;DACH1;NFIL3-5;GFI1;ETS2
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific bindingGZF1;BACH1;BACH2;PAX4;ZBTB16;MSC;ARX;PROP1
contributes_to ubiquitin-protein transferase activityKEAP1;KLHL15;KLHL40A;KBTBD2;KLHDC8A;TCEB1;TCEB1B;FBXW8;KLHL5

BACH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BACH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BACH1.

MAFG; MAF; FOS; ATF2; CREB1; ATF7; ATF1; DDIT3; BATF; meq_gahvm; MAFB; Bach1; ANAPC5; h0y2u5_human; TMEM208

Itoh-Nakadai, A; Hikota, R; et al. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. NATURE IMMUNOLOGY 15:1171-1180(2014).
Igarashi, K; Watanabe-Matsui, M; et al. Wearing Red for Signaling: The Heme-Bach Axis in Heme Metabolism, Oxidative Stress Response and Iron Immunology. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 232:229-253(2014).
  • Q&As
  • Reviews

Q&As (7)

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How does BACH2 affect ischemic angiogenesis? 10/29/2021

BACH2 has been shown to suppress ischemic angiogenesis, implicating its role in vascular and tissue responses to ischemic conditions.

In what cellular processes does BACH2 play a role? 02/02/2021

BACH2 has a key regulatory role in the production of reactive oxygen species, cell cycle regulation, heme homeostasis, hematopoiesis, and immunity.

How does BACH2 contribute to heme homeostasis? 01/13/2021

BACH2 plays a regulatory role in heme homeostasis, influencing the balance of heme production and utilization within the cell.

What impact does BACH2 have on breast cancer metastasis? 04/16/2020

BACH2 has been shown to promote breast cancer metastasis, indicating its involvement in cancer progression and dissemination.

What is the primary function of BACH2? 07/27/2019

BACH2 functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in gene promoters.

Why is tight control necessary for therapies targeting BACH2 expression? 06/09/2018

Therapies designed to manipulate BACH2 expression need to be tightly controlled and tailored for each specific disease state or cell type due to its diverse functions.

What are the varied functions of BACH2 in different cell types? 03/26/2018

BACH2 expression and function differ between cell types, influencing various cellular and physiological processes based on the specific cell type.

Customer Reviews (3)

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Reviews
11/08/2022

    Its reliability over time reduced the need for frequent reordering, saving both time and resources.

    05/17/2020

      The product's durability allowed us to confidently plan experiments without concerns about degradation.

      03/23/2017

        We appreciated the ongoing assistance from the company, which contributed to the product's success in our experiments.

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