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BAD

  • Official Full Name

    BCL2-associated agonist of cell death

  • Overview

    The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
  • Synonyms

    BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; bcl2 antagonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BAD-1433H Recombinant Human BCL2-associated Agonist Of Cell Death, GST-tagged Sf9 Insect Cell GST
Human BAD-048H Recombinant Human BAD protein, GST-tagged Wheat Germ GST
Human BAD-26296TH Recombinant Human BAD E.coli N/A
Human BAD-26298TH Recombinant Human BAD N/A
Human BAD-6973H Recombinant Human BAD, GST-tagged Sf9 Insect Cell GST Full length
Human BAD-82H Recombinant Human BCL2-associated Agonist Of Cell Death E.coli N/A
Human BAD-168H Recombinant Human v protein, His-tagged E.coli His
Human BAD-8529HCL Recombinant Human BAD 293 Cell Lysate HEK293 N/A
Human BAD-564H Recombinant Human BAD protein, His-GST-tagged E.coli His/GST Met1~Gln168
Human BAD-419H-B Recombinant Human BAD Protein Pre-coupled Magnetic Beads HEK293
Human BAD-752HFL Recombinant Full Length Human BAD Protein, C-Flag-tagged Mammalian cells Flag
Human BAD-1767HF Recombinant Full Length Human BAD Protein, GST-tagged In Vitro Cell Free System GST 168 amino acids
Human BAD-419H Recombinant Human BAD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BAD-0222H Recombinant Human BAD Protein (Met1-Gln168), His-tagged E.coli His Met1-Gln168
Mouse BAD-2269M Recombinant Mouse BAD Protein Mammalian Cell His
Mouse BAD-949M Recombinant Mouse BAD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BAD-949M-B Recombinant Mouse BAD Protein Pre-coupled Magnetic Beads HEK293
Mouse Bad-689M Recombinant Mouse Bad Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat BAD-931R Recombinant Rat BAD Protein Mammalian Cell His
Rat BAD-589R Recombinant Rat BAD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BAD-589R-B Recombinant Rat BAD Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BAD-505R Recombinant Rhesus monkey BAD Protein, His-tagged Mammalian Cell His
Rhesus Macaque BAD-333R Recombinant Rhesus Macaque BAD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BAD-333R-B Recombinant Rhesus Macaque BAD Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BAD Related Articles
  • BAD Related Gene Family
  • BAD Related Signal Pathway

BAD involved in several pathways and played different roles in them. We selected most pathways BAD participated on our site, such as ErbB signaling pathway, Ras signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayCAMK2B1;PTK2;PAK4;NCK2;CAMK2D;PIK3R5;CBL;PIK3CG;ERBB4A
Ras signaling pathwayRALBP1;INSR;MAPK3;GNB2;NFKB1;FGF6;RASA1;FIGF;SHC1
cGMP-PKG signaling pathwayBAD;VASP;PPP3R1;CREB5;GTF2I;NFATC4;CALM3;VDAC2;PDE5A
cAMP signaling pathwayGNAI3;CAMK2D;GPR81;HCN2;PRKACB;GNAS;FXYD2;CALM3;FXYD1
PIK-Akt signaling pathwayFASLG;PIK3CB;INS;GNG5;FOXO3;PDPK1;FGF13;FGF22;TCL1A
ApoptosisE2F1;HMGB2;DYNLL2;NMT1;GZMF;HMGB2A;RIPK1L;CAPN1A;PIK3R3
VEGF signaling pathwayPRKCA;MAPK14A;SPHK2;RAC3;PLCG2;PTGS2B;NOS3;SPHK1;CASP9
Focal adhesionCAV1;VASPA;IGF1;VTN;TLN1;HGF;RAP1B;FYNA;RAP1AB
Neurotrophin signaling pathwayIRAK2;MAP3K3;NFKBIA;AKT2;PDPK1;MAPK10;RAC1;ARHGDIB;NTRK1
Insulin signaling pathwayPRKCI;PHKA2;PRKAB1;EIF4E1C;TSC1A;CALM;CALM3;PIK3R3B;PDPK1B
Thyroid hormone signaling pathwayPLCD1;HIF1A;ATP1B4;KRAS;STAT1;MAPK1;TRP53;RCAN2;PIK3CA
Alzheimers diseaseGAPDH;CALM4;NDUFB1;CASP9;APOE;APH1C;NDUFC1;SNCA;NDUFS1
Amyotrophic lateral sclerosis (ALS)TNF;PPP3CB;TRP53;BAX;CASP9;TP53;MAPK14;TNFRSF1B;MAP3K5
ToxoplasmosisIRAK1;HLA-DRB5;BIRC7;CASP8;PIK3CG;LAMA3;HLA-DPA1;LAMB1;STAT3
TuberculosisCALML5;CASP9;FCGR3;AKT2;TGFB3;Casp3;ATP6V0C;RFXAP;FCGR2A
Hepatitis CPIAS1;PPP2R2A;EIF2AK1;IFNA7;SCARB1;MAPK9;OAS3;PPP2R2D;CLDN7
Hepatitis BSTAT6;SMAD3;MAP2K1;MAP2K4;ATF4;MAPK8;CCNA2;CREB3L2;PIK3R1
Pathways in cancerCBL;Adcy4;PPARD;WNT7B;WNT7A;FGF22;RALB;RAC2;FLT3LG
Viral carcinogenesisHIST1H2BL;HIST1H4I;H2-Q10;PIK3R5;HDAC1;RELA;LTBR;TRADD;NFKB2
Colorectal cancerSMAD2;APPL1;BAD;BAX;MAPK9;MAP2K1;AXIN2;MLH1;BIRC5
Pancreatic cancerRAC3;PIK3R3;CASP9;PLD1;MAPK3;AKT2;PIK3CB;MAPK8;RAD51
Endometrial cancerAPC2;GRB2;FOXO3;CTNNA2;PDPK1;MAPK3;AKT1;ILK;TCF7L2
Prostate cancerNOXA1;IGF1;PIK3CA;Ar;CPN1;BCL2;MAP2K2;PIK3R5;ACTL6B
MelanomaPDGFRB;PTEN;FGF6;FGFR1;BRAF;IGF1;AKT2;FGF13;PDGFC
Chronic myeloid leukemiaBCR;STAT5A;MAPK1;BCL2L1;HDAC2;SHC1;TGFB3;PTPN11;ARAF
Acute myeloid leukemiaRAF1;ZBTB16;BAD;MTOR;EIF4EBP1;PIK3R5;NRAS;AKT3;STAT5A
Non-small cell lung cancerNRAS;PIK3R3;EML4;CCND1;HRAS;ARAF;SOS1;GRB2;PDPK1

BAD has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process, lipid binding, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAD itself. We selected most functions BAD had, and list some proteins which have the same functions with BAD. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activator activity involved in apoptotic processRPS27L;APAF1;CARD8;NLRP12;CTSH;NOD1;BCL2L13;MAPK9;NLRP1
lipid bindingCOQ9;TRIP10;BAIAP2L2B;DBIL5;NME4;CYTH2;ESYT3;HSP12;PLUNC
phospholipid bindingBIN2;SGIP1;NOXO1;PACSIN1A;BPIFC;NUP35;DAPP1;RASAL1;GRK5
protein bindingCD300A;ACSS1;ATXN7;PNPT1;PHF10;PGF;PKD2;GAGE2D;LRFN2
protein heterodimerization activityHIST1H3A;DRD1A;HER11;HIST1H3D;GRIN1;HIST1H3H;EXT2;IKZF4;SFRP5
protein kinase B bindingBCL10;RARA;CCDC88A;PINK1;PDE3B;BAD;TRAF6;APPL1;CDC37
protein kinase bindingEEF1A2;CCNYL1;PKD1;KAT2B;LATS1;PGAM1;TRAF6;HDAC4;CD3E
protein phosphatase 2B bindingAKAP5;AKAP1;PPP3CB;SLC9A1;SOD1;BAD;MYOZ2;ATP2B4

BAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAD here. Most of them are supplied by our site. Hope this information will be useful for your research of BAD.

BCL2L1; BCL2; BCL2L1

Gamez, C; Zafra, MP; et al. Simulated gastrointestinal digestion reduces the allergic reactivity of shrimp extract proteins and tropomyosin. FOOD CHEMISTRY 173:475-481(2015).
Omar, AAH; Haglund, C; et al. MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 119:459-467(2015).
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