BAG2
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Official Full Name
BCL2-associated athanogene 2
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Overview
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. -
Synonyms
BAG2; BCL2-associated athanogene 2; BAG family molecular chaperone regulator 2; bcl-2-associated athanogene 2; BAG-family molecular chaperone regulator-2; dJ417I1.2 (BAG-family molecular chaperone regulator 2); BAG-2; dJ417I1.2; KIAA0576; MGC149462;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BAG2 Related Articles
- BAG2 Related Research Area
BAG2 involved in several pathways and played different roles in them. We selected most pathways BAG2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein processing in endoplasmic reticulum | ATXN3;NFE2L2;PDIA3;DNAJC3;HSPA1L;ERP29;DNAJC1;UFD1L;CUL1A |
BAG2 has several biochemical functions, for example, chaperone binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG2 itself. We selected most functions BAG2 had, and list some proteins which have the same functions with BAG2. You can find most of the proteins on our site.
Function | Related Protein |
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chaperone binding | BAG5;DNAJB7;CXorf41;BIRC5;H2-KE2;AHSA2;DNAJB1;Alb;BAG1 |
identical protein binding | GDF5;KHDC1A;PHYKPL;NONO;NPR2;FRS3;REG3B;DES;PAICS |
protein binding | GORASP2;FAM58A;GGA2;PEPD;ZNHIT3;ASF1B;CHRDL2;SPOP;TROAP |
BAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG2.
MLF2; DNAJC7; HSPA8; SGTA; EBNA-LP; q96be0_human; STUB1
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