Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

BBC3

  • Official Full Name

    BCL2 binding component 3

  • Overview

    This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
  • Synonyms

    BBC3; BCL2 binding component 3; JFY1; PUMA; JFY-1; bcl-2-binding component 3; p53 up-regulated modulator of apoptosis;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BBC3-1561H Recombinant Human BCL2 Binding Component 3, His-tagged E.coli His
Human BBC3-26H Recombinant Human BBC3 protein, His-tagged E.coli His 116aa(including fusion tag)
Human BBC3-8505HCL Recombinant Human BBC3 293 Cell Lysate HEK293 N/A
Human BBC3-5229H Recombinant Human BBC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BBC3-427H-B Recombinant Human BBC3 Protein Pre-coupled Magnetic Beads HEK293
Human BBC3-558HFL Recombinant Full Length Human BBC3 Protein, C-Flag-tagged Mammalian cells Flag
Human BBC3-562H Recombinant Human BBC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BBC3-427H Recombinant Human BBC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bbc3-1827M Recombinant Mouse Bbc3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Bbc3-1958R Recombinant Rat Bbc3 protein, His & T7-tagged E.coli His/T7 Arg76~Val170 (Accession# Q80ZG6)
Rat BBC3-946R Recombinant Rat BBC3 Protein Mammalian Cell His
Rat BBC3-604R Recombinant Rat BBC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BBC3-604R-B Recombinant Rat BBC3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish BBC3-4413Z Recombinant Zebrafish BBC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BBC3 Related Articles

BBC3 involved in several pathways and played different roles in them. We selected most pathways BBC3 participated on our site, such as p signaling pathway, Hippo signaling pathway, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p signaling pathwaySHISA5;GADD45B;TRP53;TSC2;RPRM;PTEN;PTENA;CCNG2;PERP
Hippo signaling pathwayDVL3;FZD6;BIRC5;APC;WNT10B;YWHAH;MOB1A;BMPR2;NF2
Huntingtons diseaseNDUFA2;SDHB;POLR2C;POLR2B;TBPL1;NDUFA13;DNAH6;NDUFS1;NDUFS6
MeaslesIFNA2;CD209A;PIK3R3;PRKCQ;IFNA10;TNFAIP3;IRAK1;OAS3;TRP53

BBC3 has several biochemical functions, for example, ATPase binding, glycoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBC3 itself. We selected most functions BBC3 had, and list some proteins which have the same functions with BBC3. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingATP6V0A1A;DNAJC10;CAV1;PEX19;DRD1;NKAIN1;GABARAPL2;NHP2L1;ATP6V1G1
glycoprotein bindingShh;TGFB1;OS9;VLDLR;FLNA;HSPA5;RASA1;IDE;Serpina1b
protein bindingCRTC2;FCGR2B;PQBP1;Clec4n;OSBPL7;KIAA1274;ENTPD3;H2AFY;CRYAB

BBC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBC3.

Myers, M; Morgan, FH; et al. PUMA regulates germ cell loss and primordial follicle endowment in mice. REPRODUCTION 148:211-219(2014).
Ray, S; Zhao, YX; et al. Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis. CELLULAR SIGNALLING 26:1445-1455(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All BBC3 Products

Required fields are marked with *

My Review for All BBC3 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends