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BCL10

  • Official Full Name

    B-cell CLL/lymphoma 10

  • Overview

    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
  • Synonyms

    BCL10; B-cell CLL/lymphoma 10; CLAP; mE10; CIPER; c-E10; CARMEN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCL10-1016H Active Recombinant Human B-cell CLL/lymphoma 10 Sf9 Insect Cell N/A
Human BCL10-8496H Active Recombinant Human BCL10, His-tagged Sf21 Insect Cell His
Human BCL10-16H Recombinant Human BCL10 Protein, His-tagged E. coli His
Human BCL10-141H Recombinant Human BCL10 Protein, GST-tagged Wheat Germ GST
Human BCL10-8490HCL Recombinant Human BCL10 293 Cell Lysate HEK293 N/A
Human BCL10-1579HF Recombinant Full Length Human BCL10 Protein, GST-tagged In Vitro Cell Free System GST 233 amino acids
Human BCL10-2579H Recombinant Human BCL10 protein, His-SUMO-tagged E.coli His-SUMO 1-233aa
Mouse Bcl10-555M Recombinant Mouse Bcl10 Protein, His-tagged E.coli His Met1~Gln233
Rat BCL10-956R Recombinant Rat BCL10 Protein Mammalian Cell His
Rat BCL10-614R Recombinant Rat BCL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BCL10-614R-B Recombinant Rat BCL10 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BCL10-521R Recombinant Rhesus monkey BCL10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BCL10-349R Recombinant Rhesus Macaque BCL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BCL10-349R-B Recombinant Rhesus Macaque BCL10 Protein Pre-coupled Magnetic Beads HEK293
Chicken BCL10-4495C Recombinant Chicken BCL10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCL10 Related Articles
  • BCL10 Related Gene Family
  • BCL10 Related Research Area

BCL10 involved in several pathways and played different roles in them. We selected most pathways BCL10 participated on our site, such as NF-kappa B signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayCCL13;CCL21;Ccl21c;GADD45B;ZAP70;CCL21B;Bcl2a1b;IRAK4;TNFSF13B
T cell receptor signaling pathwayCD247;AKT2;FOS;IFNG;RAF1;PRKCQ;NFKBIB;VAV2;FYN
B cell receptor signaling pathwaycgr2b;ARPC5;DOK1B;SYK;IFITM1;FCGR2B;MAPK3;NEDD9;ARPC1B
TuberculosisCD209A;RFXANK;Ifna15;ITGAX;CAMK2G;FCGR3;ATP6V1H;PPP3R1;MAPK13

BCL10 has several biochemical functions, for example, NF-kappaB binding, enzyme binding, contributes_to kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL10 itself. We selected most functions BCL10 had, and list some proteins which have the same functions with BCL10. You can find most of the proteins on our site.

Function Related Protein
NF-kappaB bindingCOMMD6;NFKBIA;TAF4B;RNF25;RPS3;AP1S2;RELA;FAF1;HIF1AN
enzyme bindingSTC2;PLSCR1;PIAS1;CYB5A;EGFR;DAXX;RARA;GSTM7;HSPA6
contributes_to kinase activator activityBCL10;MALT1
kinase bindingSP100;TNFAIP3;PPP1R9B;TENC1;JAKMIP2;WWC3;GFAP;CHP1;DLG4
protease bindingSERPINB4;COMP;TIMP2;CNTNAP2;Serpina1b;TIMP3;UBC;ELANE;SRI
protein C-terminus bindingSLC4A1;TCF4;FIGN;PLEKHB1;SHANK2;VTA1;PIAS4;MED12;ERCC6
protein bindingPRSS21;CACNA1SB;TSSK3;DYRK1A;DUSP2;KIR2DL4;INPP5B;CTSH;USP17L2
protein kinase B bindingPINK1;PDE3B;TRAF6;ANKRD2;BCL10;RARA;CCDC88A;APPL1;BAD
protein kinase bindingPTPRK;FAM83A;GSTP2;IKBKB;MAML1;HSP90AB1;CHEK2;ELAVL1;DNM2
protein self-associationTRP53;TTN;TP53;SLC9A3R1;CCL5;CBR2;CNTN2;DYRK1A;L1CAM
transcription coactivator activityMED17;TADA3;E4F1;ING4;TAF7L;RFXAP;SUB1A;BRCA1;TAF6L
transcription factor bindingHEY1;HDAC3;BCOR;APBB3;NFYC;ETS1;NKX2;ATF7;SNF8
ubiquitin bindingBRAP;UBAP1;D17WSU92E;HSPB1;CRY1;NUP62;UCHL3;SMAD3;NBR1
ubiquitin protein ligase bindingYWHAZ;GSK3B;CDC34;TMEM189;USP25;H2-AB1;TRAF2;PARK2;CUL1A

BCL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL10.

MALT1; AKT1; CARD11

Punwani, D; Wang, HP; et al. Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation. JOURNAL OF CLINICAL IMMUNOLOGY 35:135-146(2015).
Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).
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