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BCR

  • Official Full Name

    breakpoint cluster region

  • Overview

    The Bcr gene was orginally identified by its presence in the chimeric Bcr-Abl oncogene. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain, and a region that binds SH2 domains. The middle of the protein h
  • Synonyms

    BCR; breakpoint cluster region; BCR1, D22S11; breakpoint cluster region protein; ALL; CML; D22S662; PHL; renal carcinoma antigen NY-REN-26; BCR1; D22S11; FLJ16453;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCR-25H Active Recombinant Human BCR/RET protein, GST-tagged Insect Cell GST
Human BCR-10196H Recombinant Human BCR, His-tagged E.coli His 1-350a.a.
Human BCR-26665TH Recombinant Human BCR N/A
Human BCR-177H Recombinant Human BCR Protein, GST-tagged Wheat Germ GST
Human BCR-1543H Recombinant Human Breakpoint Cluster Region protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BCR-1436H Recombinant Human Breakpoint Cluster Region,GST-tagged Sf9 Insect Cell GST
Human BCR-166HCL Recombinant Human BCR cell lysate N/A
Human BCR-4862H Recombinant Human BCR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BCR-3336H Recombinant Human BCR protein, His-tagged E.coli His 286-494 aa
Human BCR-558H Recombinant Human BCR Protein, His-tagged E.coli His Arg1042~Val1243
Human BCR-2637H Recombinant Human BCR protein(161-260 aa), C-His-tagged E. coli C-His 161-260 aa
Human BCR-0218H Recombinant Human BCR Protein (174-331), His-tagged E.coli His 174-331
Human BCR-7032HFL Recombinant Full Length Human Breakpoint Cluster Region protein, Flag-tagged Mamanlian cells Flag
Human BCR-0219H Recombinant Human BCR Protein (Lys174-Asp331), N-His-tagged E.coli N-His Lys174-Asp331
Mouse Bcr-559M Recombinant Mouse Bcr Protein, His-tagged E.coli His Met1042~Thr1268
Mouse Bcr-463M Recombinant Mouse Bcr Protein, MYC/DDK-tagged HEK293T MYC/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCR Related Articles
  • BCR Related Research Area
  • BCR Related Signal Pathway

BCR involved in several pathways and played different roles in them. We selected most pathways BCR participated on our site, such as Pathways in cancer, Chronic myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerTGFB2;IL-8;GNG3;NTRK1;APC;FGF4;FZD6;LAMB2;XIAP
Chronic myeloid leukemiaCBL;SMAD4;SHC1;CTBP1;MAPK3;CBLC;MDM2;MAPK1;PIK3R1

BCR has several biochemical functions, for example, ATP binding, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCR itself. We selected most functions BCR had, and list some proteins which have the same functions with BCR. You can find most of the proteins on our site.

Function Related Protein
ATP bindingOASL2;ITGB1BP3;PRKCHA;DNAJA2;ENPP1;PPIP5K1;NEK10;LTK;GRK1B
GTPase activator activityARHGAP12;ARHGAP44;ARHGAP27;ADAP2;WNT11;RIC8;DOCK4;SGSM2;SMAP1
Rho guanyl-nucleotide exchange factor activityARHGEF6;TRIO;ARHGEF37;FARP1;DCLRE1B;PLEKHG5;DOCK9;DNMBP;PREX1
enzyme bindingPPP3CA;DAOA;NOTCH1;HLCS;CRB2;FOXO4;TSPAN33;KAT8;HMGA1
kinase activityDCKL1B;TNK2B;CDKN1D;PTK6B;CKBA;CAMK2A;TNIKA;PRKCHB;EPHB2B
protein bindingIL17RE;UBOX5;HAUS1;KRTAP3-2;IL28RA;OTUD7B;CDCA5;BIK;ANXA5
protein serine/threonine kinase activityADCK2;CAMK2A;PKN1;RPS6KC1;CHEK1;CDK15;SIK2A;NLK2;IRAK4
protein tyrosine kinase activityEGFR;MAP2K4;ERBB3A;FGFR3;TESK1;PTK7A;KITB;YES1;INSR

BCR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCR here. Most of them are supplied by our site. Hope this information will be useful for your research of BCR.

GRB2; APBA3; TNKS2; TP53

Sagiv-Barfi, I; Kohrt, HEK; et al. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E966-E972(2015).
McHeyzer-Williams, LJ; Milpied, PJ; et al. Class-switched memory B cells remodel BCRs within secondary germinal centers. NATURE IMMUNOLOGY 16:296-U129(2015).
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