• Official Full Name
  • chromosome 14 open reading frame 169
  • Background
  • NO66 is a lysine-specific demethylase that removes methyl groups from histone H3 at lysine 4 and and lysine 36. This enzyme has been shown to more readily demethylate trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 Lys4 (H3K4me1) consistent with its role in modulating the histone code. This protein is a highly conserved, constitutive nucleolar component that shows a dual localization pattern with strong enrichment in the granular part of nucleoli and in distinct nucleoplasmic entities.
  • Synonyms
  • C14ORF169; chromosome 14 open reading frame 169; lysine-specific demethylase NO66; FLJ21802; NO66; hsNO66; nucleolar protein 66; MYC-associated protein with JmjC domain; MAPJD
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C14orf169, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human C14orf169 cell lysate

Protein Function

C14ORF169 has several biochemical functions, for example, histone demethylase activity (H3-K36 specific), histone demethylase activity (H3-K4 specific), iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C14ORF169 itself. We selected most functions C14ORF169 had, and list some proteins which have the same functions with C14ORF169. You can find most of the proteins on our site.
Related Protein
Function histone demethylase activity (H3-K36 specific)
Related Protein PHF8; KDM2A; JMJD5; C14orf169; KDM2B; KDM4A; JHDM1D; KDM8
Function histone demethylase activity (H3-K4 specific)
Related Protein C14orf169; KDM1A; KDM5B; KDM5D; KDM5C
Function iron ion binding
Related Protein ALOX5A; FTL; SC4MOL; CYP8B1; CYP2AA2; CYP2W1; CYP2F2; PAH; LEPRE1; PLOD3
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Related Protein KDM5C; C14orf169; EGLN2; TYW5; KDM5A; KDM5D; EGLN3; KDM5BB; JHDM1D; HIF1AN
Function protein binding
Related Protein CLN3; YY1A; ZNF207; WFS1; CYTH2; EPB41; POLD2; IGSF8; DPEP3; THBD

Interacting Protein

C14ORF169 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C14ORF169 here. Most of them are supplied by our site. Hope this information will be useful for your research of C14ORF169.
Sp7; USP42; q7chg5_yerpe; Srp72; NOP56; VIM; Eif3a; RPL10; MNDA; HNRNPU; C1qbp