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C5

  • Official Full Name

    complement component 5

  • Overview

    The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
  • Synonyms

    C5; complement component 5; C5D; C5a; C5b; ECLZB; CPAMD4; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Cynomolgus
  • Human
  • Mouse
  • Pig
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Human Plasma
  • Human Serum
  • Mouse
  • Wheat Germ
  • Yeast
  • Biotin
  • GST
  • His
  • Myc
  • His|Flag
  • His|GST
  • SUMO
  • human|IgG1|Fc
  • N/A
  • N
  • No tag
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human C5-4756H Active Recombinant Human C5 protein E.coli N/A Leu679-Arg751
Human C5-10540H Active Native Human C5 Human Serum N/A
Human C5-1873H Active Recombinant Human C5 protein, His-tagged E.coli His Leu 679 - Arg 751
Human C5-0077H Recombinant Human C5 Protein, GST-Tagged Wheat Germ GST
Human C5-562H Recombinant Human C5 Protein, GST-tagged E.coli GST Thr678~Arg751
Human C5-26131TH Recombinant Human C5, His-tagged E.coli His
Human C5-10539H Recombinant Human C5, His-tagged E.coli His C-term-259a.a.
Human C5-8020HCL Recombinant Human C5 293 Cell Lysate HEK293 N/A
Human C5-2611H Recombinant Human C5 protein, His-SUMO-tagged E.coli His-SUMO 678-751aa
Human DMABT-H19242 Mouse Anti-C5 Monoclonal Antibody Mouse N/A
Human C5-092H Recombinant Human C5 protein, Fc-tagged HEK293 human/IgG1/Fc Leu679-Arg751
Human C5-4992H Recombinant Human C5 protein, His-tagged HEK293 His 678-751aa
Human C5-344H Recombinant Human C5 Protein, His-tagged E.coli N-His Gln19-Ser350
Human DMABT-H19243 Mouse Anti-C5 Monoclonal Antibody Mouse Biotin
Human C5-851H Recombinant Human C5 protein (W917S), His-tagged HEK293 His Gln19-Cys1676
Human C5-0275H Recombinant Human C5 Protein (Asp822-Lys925), N-His-tagged E.coli N-His Asp822-Lys925
Human C5-345H Recombinant Human C5 Protein, His-tagged E.coli N-His Ser1055-Asn1513
Human C5-575H Recombinant Human C5 Protein (Gln19-Cys1676), His-FLAG-tagged HEK293 His/Flag Gln19-Cys1676
Human CAB11483MH Mouse Anti-Human Complement Component 5 Monoclonal Antibody Mouse N/A
Human C5-536H Active Recombinant Human C5 protein, His-tagged HEK293 His Gln19-Cys1676
Human C5-0052H Recombinant Human C5 Protein (G981-Q1306), Tag Free E.coli No tag G981-Q1306
Human C5-9288H Recombinant Human C5 protein (R885H), His-tagged HEK293 His Gln19-Cys1676
Human C5-53H Native Human Complement C5 Human Plasma N/A
Human C5-502H Recombinant Human C5 protein, GST-tagged E. coli GST 1418-1676 aa
Human C5-0053H Recombinant Human C5 Protein (G981-Q1306), His tagged E.coli His G981-Q1306
Human C5-0276H Recombinant Human C5 Protein (Leu679-Arg751), Tag Free E.coli Tag Free Leu679-Arg751
Human C5-1287H Recombinant Human C5 protein E.coli N/A Thr678-Arg751
Human C5-0277H Recombinant Human C5 Protein (Thr678-Arg751), GST-tagged E.coli GST Thr678-Arg751
Mouse C5-2711M Recombinant Mouse C5 Protein, His-tagged E.coli N-His Asn679-Arg755
Mouse C5-0293M Recombinant Mouse C5 protein E.coli N/A Asn679-Arg755
Mouse C5-1940M Recombinant Mouse C5 protein, Biotinylated E.coli N/A Asn679-Arg755
Rat C5-565R Recombinant Rat C5 Protein, His/GST-tagged E.coli His/GST Gln12~Ile64
Rat C5-564R Recombinant Rat C5 Protein, His/GST-tagged E.coli His/GST Asp1~Arg77
Rat C5-347R Recombinant Rat C5 Protein, His-tagged HEK293F N-His Asp1-Arg77
Rat C5-2612R Recombinant Rat C5 protein, His&Myc-tagged E.coli His&Myc 1-77aa
Rat C5-346R Recombinant Rat C5 Protein, His-tagged E.coli N-His Cys1541-Ala1688
Rat C5-511R Recombinant Rat C5 protein, His-tagged HEK293 His Gln24-Ala1688
Cynomolgus C5-1872C Active Recombinant Cynomolgus C5 protein, His-tagged E.coli His Met 678 - Arg 751
Cynomolgus C5-453C Recombinant Cynomolgus C5 protein HEK293 N/A Met678-Arg751
Cynomolgus C5-452C Recombinant Cynomolgus C5 protein E.coli Met678-Arg751
Cynomolgus C5-681C Recombinant Cynomolgus C5 protein, His-tagged HEK293 His Gln19-Cys1676
Pig C5-5355P Recombinant Pig C5 protein, His-tagged Yeast His 1-74aa
Pig C5-348P Recombinant Pig C5 Protein, His-tagged E.coli N-His Met1-Arg74
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • C5 Related Articles
  • C5 Related Research Area

C5 involved in several pathways and played different roles in them. We selected most pathways C5 participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesFGG;CFH;F5;CD59A;SERPINA1A;CD46;C5AR1;SERPINA1;Serpina1b
Prion diseasesNCAM2;C9;NOTCH1;LOC100033925;PRKACB;PRKACA;C8G;ELK1;PRKACG
PertussisIl23a;ITGB1;ITGA5;IRF8;IL12B;MAPK11;C4BPB;NFKB1;IRF1
Staphylococcus aureus infectionITGB2L;DSG1A;CFB;HLA-DPB1;ITGAM;C1QA;MBL2;FCGR1;FCGR1A
Herpes simplex infectionCASP8;PVRL2;SRSF1B;HNRPK;DAXX;SRSF1A;CSNK2A2A;TAF9B;STAT1B
Systemic lupus erythematosusHIST3H2BB-PS;HIST1H2BI;HIST1H4J;HLA-DPA1;HIST1H2AO;H2AFB1;HLA-DQB1;HIST1H3C;C6

C5 has several biochemical functions, for example, chemokine activity, endopeptidase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C5 itself. We selected most functions C5 had, and list some proteins which have the same functions with C5. You can find most of the proteins on our site.

Function Related Protein
chemokine activityPF4;AMCF-II;CXCL16;CCL33.3;Ccl12;CXCL6;Ccl21c;IL-8;CCL19
endopeptidase inhibitor activityCST14B.1;PCSK1N;USP14;SLPI;ITIH2;LPA;PROS1;C4A;C3A.3
protein bindingOCIAD1;CRABP2;CENPH;ACPL2;RDM1;ASIC2;CHCHD2;TXNDC9;C3orf52
receptor bindingSLC9A3R1;C1QTNF2;CADM1A;MCHR1;SSFA2;HLA-B;WNT5B;SMARCD1;CYTL1

C5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C5 here. Most of them are supplied by our site. Hope this information will be useful for your research of C5.

CREB3L1; vco3_najka; d3jib2_staau

Hallstensen, RF; Bergseth, G; et al. Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn. IMMUNOBIOLOGY 220:452-459(2015).
Ohta, T; Urayama, K; et al. Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. PEDIATRIC NEPHROLOGY 30:603-608(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can C5 inhibition be a potential therapy for neuroinflammatory conditions such as multiple sclerosis? 01/10/2023

Yes, C5 inhibition has shown promise in treating multiple sclerosis by modulating the inflammatory response and reducing damage to the central nervous system.

How is the C5 protein targeted in therapeutic interventions, and what are the available modalities? 08/25/2022

C5 can be targeted using monoclonal antibodies, such as eculizumab, which inhibits its activity. This approach has been successful in managing various complement-related disorders.

How is the C5 protein involved in the pathogenesis of diseases like PNH? 02/21/2019

In PNH, a mutation leads to uncontrolled complement activation, resulting in the destruction of red blood cells. Inhibiting C5 can prevent this process and improve clinical outcomes.

How does C5 inhibition impact the risk of infections in patients undergoing treatment? 11/16/2016

C5 inhibition can increase susceptibility to certain infections. Close monitoring and appropriate preventive measures are essential to manage the infection risk in patients receiving C5-targeted therapies.

What role does C5 play in the progression of inflammatory diseases like rheumatoid arthritis? 09/01/2016

In rheumatoid arthritis, C5 contributes to inflammation and joint damage. Targeting C5 in treatment may help mitigate the inflammatory response.

Customer Reviews (3)

Write a review
Reviews
09/29/2019

    Whether I am studying protein interactions, cellular localization, or signaling pathways, the C5 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.

    10/23/2018

      Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.

      11/20/2016

        Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.

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