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Cacnb4

  • Official Full Name

    Calcium Channel, Voltage-Dependent, Beta 4 Subunit

  • Overview

    Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. Specifically, this gene encodes a member of the β subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of α1, α3/δ, β, andγ subunits in a 1:1:1:1 ratio. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling theα1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
  • Synonyms

    CACNB4; Cavβ4 Calcium Channel; EA5; EJM; calcium channel, voltage-dependent, beta 4 subunit; CAB4; EIG9; EJM4; EJM6; CACNLB4; voltage-dependent L-type calcium channel subunit beta-4; calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207228; OTTHUMP00000207246; OTTHUMP00000207247; OTTHUMP00000207248; OTTHUMP00000207249; OTTHUMP00000209460;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CACNB4-10640H Recombinant Human CACNB4, His-tagged E.coli His 1-350a.a.
Human CACNB4-0274H Recombinant Human CACNB4 Protein, GST-Tagged Wheat Germ GST
Human CACNB4-7902HCL Recombinant Human CACNB4 293 Cell Lysate HEK293 N/A
Human CACNB4-3023HF Recombinant Full Length Human CACNB4 Protein, GST-tagged In Vitro Cell Free System GST 520 amino acids
Human CACNB4-056H Recombinant Human CACNB4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Cacnb4-738M Recombinant Mouse Cacnb4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque CACNB4-603R Recombinant Rhesus monkey CACNB4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CACNB4-431R-B Recombinant Rhesus Macaque CACNB4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CACNB4-431R Recombinant Rhesus Macaque CACNB4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CACNB4-5916C Recombinant Chicken CACNB4 Mammalian Cell His
Chicken CACNB4-1136C Recombinant Chicken CACNB4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Cacnb4 Related Articles

Cacnb4 involved in several pathways and played different roles in them. We selected most pathways Cacnb4 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cacnb4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayRAF1;TNFRSF1A;PPP5C;GRB2;RAP1B;MOS;RAC3B;MAP2K4B;TAOK3
Cardiac muscle contractionTPM4B;UQCRFS1;SLC9A1;ACTC1;CACNA1SB;ACTC1B;COX7B2;TNNT2;COX6B2
Adrenergic signaling in cardiomyocytesTNNC1B;ADRB2;MAPK14B;RAPGEF3;CALM4;RPS6KA5;ADCY1B;MYL3;PPP1CBL
Oxytocin signaling pathwayCACNG4;PRKCA;PRKCB;MAP2K2;PRKAG1;PRKACB;PLCB3;PPP3R2;PPP1CB
Hypertrophic cardiomyopathy (HCM)PRKAG1;TPM4;SGCD;IGF1;ITGA2;CACNB1;CACNA2D2;ITGA10;TPM2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)SGCA;ITGA7;CACNB1;ACTB;ITGB7;ACTN2;CACNG6;ACTN3;CACNB2
Dilated cardiomyopathyITGB8;PRKACG;MYL3;TPM4;ACTC1;CACNB4;ITGA1;TNF;CACNB1

Cacnb4 has several biochemical functions, for example, contributes_to high voltage-gated calcium channel activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cacnb4 itself. We selected most functions Cacnb4 had, and list some proteins which have the same functions with Cacnb4. You can find most of the proteins on our site.

Function Related Protein
contributes_to high voltage-gated calcium channel activityCACNB4;CACNB2
protein bindingSQSTM1;CASQ2;AKAP8L;EIF2B5;CDC26;FGF10;ZNF34;ITSN2;EPAS1
protein kinase bindingEEF2;HDAC7;NR4A3;DOK7;USP37;JIP1;ERRFI1;GSK3B;TUBB3
contributes_to voltage-gated calcium channel activityCACNA2D1;CACNB4;CACNB3

Cacnb4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cacnb4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cacnb4.

FASLG; PTN; TBL3; MED31

Billings, SE; Clarke, GL; et al. ELKS1 and Ca2+ channel subunit beta 4 interact and colocalize at cerebellar synapses. NEUROREPORT 23:49-54(2012).
Fahanik-babaei, J; Eliassi, A; et al. Electro-pharmacological profile of a mitochondrial inner membrane big-potassium channel from rat brain. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1808:454-460(2011).
  • Q&As
  • Reviews

Q&As (7)

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What is the central biological role of CACNB4 in voltage-gated calcium channels? 09/30/2022

CACNB4 serves as an auxiliary subunit that influences the activity, surface expression, and trafficking of voltage-gated calcium channels.

In which human tissues or organs is CACNB4 predominantly found? 08/23/2022

CACNB4 is widely expressed, with significant concentrations in neural tissues and the retina.

Are there specific proteins that have been identified to interact directly with CACNB4? 07/07/2022

CACNB4 mainly interacts with the alpha-1 subunit of calcium channels, and may also associate with other proteins in specific cellular contexts.

How does CACNB4 modulate the activity and properties of calcium channels? 03/16/2022

CACNB4 can affect the channel's gating properties, potentially modifying calcium ion entry into cells during depolarization events.

What known post-translational modifications exist on CACNB4? 01/18/2022

Post-translational modifications such as phosphorylation might be present on CACNB4, influencing its function or protein-protein interactions.

How do mutations in the CACNB4 gene impact its regulatory functions? 01/09/2022

Specific mutations in the CACNB4 gene can alter its regulatory activity, affecting calcium channel behavior and related physiological processes.

Are there diseases or clinical conditions directly associated with CACNB4 alterations? 04/14/2020

Dysfunctions or mutations in CACNB4 have been associated with conditions like episodic ataxia and certain types of epilepsy.

Customer Reviews (3)

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Reviews
04/08/2022

    Affordable protein assays, ideal for our budget.

    07/14/2021

      Trustworthy source for all protein-related needs.

      02/10/2021

        Effortless protein purification, thanks to their guidance.

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