Cacnb4
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Official Full Name
Calcium Channel, Voltage-Dependent, Beta 4 Subunit
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Overview
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. Specifically, this gene encodes a member of the β subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of α1, α3/δ, β, andγ subunits in a 1:1:1:1 ratio. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling theα1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. -
Synonyms
CACNB4; Cavβ4 Calcium Channel; EA5; EJM; calcium channel, voltage-dependent, beta 4 subunit; CAB4; EIG9; EJM4; EJM6; CACNLB4; voltage-dependent L-type calcium channel subunit beta-4; calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207228; OTTHUMP00000207246; OTTHUMP00000207247; OTTHUMP00000207248; OTTHUMP00000207249; OTTHUMP00000209460;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- GST
- His
- His (Fc)
- Avi
- MYC
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CACNB4-10640H | Recombinant Human CACNB4, His-tagged | E.coli | His | 1-350a.a. | |
Human | CACNB4-0274H | Recombinant Human CACNB4 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | CACNB4-7902HCL | Recombinant Human CACNB4 293 Cell Lysate | HEK293 | N/A | ||
Human | CACNB4-3023HF | Recombinant Full Length Human CACNB4 Protein, GST-tagged | In Vitro Cell Free System | GST | 520 amino acids | |
Human | CACNB4-056H | Recombinant Human CACNB4 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK | ||
Mouse | Cacnb4-738M | Recombinant Mouse Cacnb4 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Rhesus Macaque | CACNB4-603R | Recombinant Rhesus monkey CACNB4 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | CACNB4-431R-B | Recombinant Rhesus Macaque CACNB4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | CACNB4-431R | Recombinant Rhesus Macaque CACNB4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | CACNB4-5916C | Recombinant Chicken CACNB4 | Mammalian Cell | His | ||
Chicken | CACNB4-1136C | Recombinant Chicken CACNB4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- Cacnb4 Related Articles
Cacnb4 involved in several pathways and played different roles in them. We selected most pathways Cacnb4 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cacnb4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | RAF1;TNFRSF1A;PPP5C;GRB2;RAP1B;MOS;RAC3B;MAP2K4B;TAOK3 |
Cardiac muscle contraction | TPM4B;UQCRFS1;SLC9A1;ACTC1;CACNA1SB;ACTC1B;COX7B2;TNNT2;COX6B2 |
Adrenergic signaling in cardiomyocytes | TNNC1B;ADRB2;MAPK14B;RAPGEF3;CALM4;RPS6KA5;ADCY1B;MYL3;PPP1CBL |
Oxytocin signaling pathway | CACNG4;PRKCA;PRKCB;MAP2K2;PRKAG1;PRKACB;PLCB3;PPP3R2;PPP1CB |
Hypertrophic cardiomyopathy (HCM) | PRKAG1;TPM4;SGCD;IGF1;ITGA2;CACNB1;CACNA2D2;ITGA10;TPM2 |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | SGCA;ITGA7;CACNB1;ACTB;ITGB7;ACTN2;CACNG6;ACTN3;CACNB2 |
Dilated cardiomyopathy | ITGB8;PRKACG;MYL3;TPM4;ACTC1;CACNB4;ITGA1;TNF;CACNB1 |
Cacnb4 has several biochemical functions, for example, contributes_to high voltage-gated calcium channel activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cacnb4 itself. We selected most functions Cacnb4 had, and list some proteins which have the same functions with Cacnb4. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to high voltage-gated calcium channel activity | CACNB4;CACNB2 |
protein binding | SQSTM1;CASQ2;AKAP8L;EIF2B5;CDC26;FGF10;ZNF34;ITSN2;EPAS1 |
protein kinase binding | EEF2;HDAC7;NR4A3;DOK7;USP37;JIP1;ERRFI1;GSK3B;TUBB3 |
contributes_to voltage-gated calcium channel activity | CACNA2D1;CACNB4;CACNB3 |
Cacnb4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cacnb4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cacnb4.
FASLG; PTN; TBL3; MED31
- Q&As
- Reviews
Q&As (7)
Ask a questionCACNB4 serves as an auxiliary subunit that influences the activity, surface expression, and trafficking of voltage-gated calcium channels.
CACNB4 is widely expressed, with significant concentrations in neural tissues and the retina.
CACNB4 mainly interacts with the alpha-1 subunit of calcium channels, and may also associate with other proteins in specific cellular contexts.
CACNB4 can affect the channel's gating properties, potentially modifying calcium ion entry into cells during depolarization events.
Post-translational modifications such as phosphorylation might be present on CACNB4, influencing its function or protein-protein interactions.
Specific mutations in the CACNB4 gene can alter its regulatory activity, affecting calcium channel behavior and related physiological processes.
Dysfunctions or mutations in CACNB4 have been associated with conditions like episodic ataxia and certain types of epilepsy.
Customer Reviews (3)
Write a reviewAffordable protein assays, ideal for our budget.
Trustworthy source for all protein-related needs.
Effortless protein purification, thanks to their guidance.
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