Calb2
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Official Full Name
calbindin 2
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Overview
This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. -
Synonyms
CALB2; calbindin 2; calbindin 2, 29kDa (calretinin); calretinin; CAL2; calbindin D29K; 29 kDa calbindin; calbindin 2, (29kD, calretinin); CR; CAB29;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Calb2 Related Research Area
Calb2 involved in several pathways and played different roles in them. We selected most pathways Calb2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Calb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Calb2 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Calb2 itself. We selected most functions Calb2 had, and list some proteins which have the same functions with Calb2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | SCUBE1;GSN;CHP1;CALM4;DSG1C;CELSR2;PCDHB7;SPARCL1;VSNL1A |
Calb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Calb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Calb2.
- Q&As
- Reviews
Q&As (5)
Ask a questionWhile there are no specific drugs targeting CALB2, research into calcium homeostasis modulation and CALB2's role in disease may lead to potential therapeutic avenues.
CALB2 helps establish and maintain calcium gradients within neurons, ensuring proper functioning of processes such as neurotransmission, dendritic integration, and synaptic plasticity by fine-tuning local calcium concentrations.
CALB2 can interact with transcription factors and co-factors involved in calcium-dependent gene expression, influencing the activation or repression of specific genes in response to changes in intracellular calcium levels.
CALB2 dynamically binds and releases calcium ions in response to changes in intracellular calcium concentration, fine-tuning calcium signaling during neuronal activity and synaptic transmission.
CALB2 is abundantly expressed in various neuronal populations, including cerebellar granule cells, interneurons in the cortex, and certain subtypes of neurons in the hippocampus.
Customer Reviews (3)
Write a reviewHigh-quality recombinant proteins boost research productivity.
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