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CAPZB

Official Full Name

capping protein (actin filament) muscle Z-line, beta
Overview

F-actin-capping-protein subunit beta (CapZ beta) belongs to the F-actin capping protein family, which are characteristic heterodimers, consisting of a α subunit (31-36 kDa) and a β subunit (28-32 kDa), that cap the barbed end of actin filaments within all eukaryotes. Their ability to bind the actin filaments is in a manner independent of Ca2++ and requires the C-terminal end of both subunits for optimal binding. F-actin capping protein subunit beta is contained within the Z-discs of striated muscle, where it functions to inhibit the polymerization and depolymerization of actin. Within vertebrates, there are three isoforms for each of F-actin capping protein subunit beta’s subunits. While there is almost nothing known regarding the β3 subunit, the β1 and β2 isoforms each have distinct role. The isoform β2 is predominantly expressed in non-muscle cells and is found in intercalated discs and the cell periphery, but is not observed at Z-discs. Isoform β1 is more greatly expressed in striated muscle and is localized at the Z-discs. It also contains the COOH-terminal extension necessary for capping the actin.
Synonyms

CAPZB; capping protein (actin filament) muscle Z-line, beta; F-actin-capping protein subunit beta; capZ beta; CAPB; CAPZ; CAPPB; FLJ12274; FLJ44693; MGC104401; MGC129749; MGC129750; DKFZp686K0524;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CAPZB-26238TH	Recombinant Human CAPZB, His-tagged	E.coli	His		Inquiry
Human	CAPZB-10717H	Recombinant Human CAPZB, His-tagged	E.coli	His	2-243a.a.	$319 / 25ug
Human	CAPZB-0388H	Recombinant Human CAPZB Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CAPZB-281HCL	Recombinant Human CAPZB cell lysate		N/A		Inquiry
Human	CAPZB-2633H	Recombinant Human CAPZB protein, GST-tagged	E.coli	GST	1-272aa	Inquiry
Human	CAPZB-4706H	Recombinant Human CAPZB Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CAPZB-2854HF	Recombinant Full Length Human CAPZB Protein, GST-tagged	In Vitro Cell Free System	GST	79 amino acids	Inquiry
Human	CAPZB-2484H	Recombinant Human CAPZB Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Rat	CAPZB-1130R	Recombinant Rat CAPZB Protein	Mammalian Cell	His		Inquiry
Rat	CAPZB-794R	Recombinant Rat CAPZB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CAPZB-794R-B	Recombinant Rat CAPZB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CAPZB-10302Z	Recombinant Zebrafish CAPZB	Mammalian Cell	His		Inquiry
Chicken	CAPZB-6987C	Recombinant Chicken CAPZB	Mammalian Cell	His		Inquiry
Chicken	CAPZB-4072C	Recombinant Chicken CAPZB	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CAPZB involved in several pathways and played different roles in them. We selected most pathways CAPZB participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPZB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	TSG101A;CSF1R;HSC70;PARD6A;SMURF1;CAV2;HSP70L;IL2RB;GIT2

CAPZB has several biochemical functions, for example, actin binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPZB itself. We selected most functions CAPZB had, and list some proteins which have the same functions with CAPZB. You can find most of the proteins on our site.

Function	Related Protein
actin binding	DIAPH3;CORO2B;SSH1;ACTR2B;MYH6;MYLK;SLC4A1;HIP1R;PHACTR4B
actin filament binding	WIPF2;PPP1R9A;MYO18A;TLN2A;MYH11A;TULP1;SYNE2;TLN1;TRPV4

CAPZB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPZB here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPZB.

VCAM1; GH1; MCC; DMWD; IKBKE; TWF2; UIMC1; MAP3K3; TRAF6; RIPK3; RPP14; PTN; dcyD; mfd; MRPL20