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CAST

  • Official Full Name

    calpastatin

  • Overview

    The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
  • Synonyms

    CAST; calpastatin; BS-17; calpain inhibitor; sperm BS-17 component;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CAST-27403TH Recombinant Human CAST Wheat Germ N/A 686 amino acids
Human CAST-0441H Recombinant Human CAST Protein, GST-Tagged Wheat Germ GST
Human CAST-10743H Recombinant Human CAST, GST-tagged E.coli GST N-term-350a.a.
Human CAST-27210TH Recombinant Human CAST Wheat Germ N/A 88 amino acids
Human CAST-7824HCL Recombinant Human CAST 293 Cell Lysate HEK293 N/A
Human CAST-1350H Recombinant Human CAST Protein (1-667 aa), His-tagged Yeast His 1-667 aa
Human CAST-1363H Recombinant Human CAST Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CAST-50HF Recombinant Full Length Human CAST Protein In Vitro Cell Free System 686 amino acids
Human CAST-2638H Recombinant Human CAST protein, His-tagged E.coli His 1-667aa
Human CAST-628H Recombinant Human CAST Protein, His&GST-tagged E.coli N-His&GST Ala446-Lys636
Human CAST-1434H Recombinant Human CAST Protein (Ala446-Lys636), N-His tagged E.coli N-His Ala446-Lys636
Human CAST-2751HF Recombinant Full Length Human CAST Protein, GST-tagged In Vitro Cell Free System GST 686 amino acids
Mouse Cast-776M Recombinant Mouse Cast Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CAST-1149R Recombinant Rat CAST Protein Mammalian Cell His
Rat CAST-807R-B Recombinant Rat CAST Protein Pre-coupled Magnetic Beads HEK293
Rat CAST-807R Recombinant Rat CAST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CAST-7075Z Recombinant Zebrafish CAST Mammalian Cell His
Chicken CAST-3882C Recombinant Chicken CAST Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CAST Related Articles

CAST involved in several pathways and played different roles in them. We selected most pathways CAST participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CAST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CAST has several biochemical functions, for example, calcium-dependent cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAST itself. We selected most functions CAST had, and list some proteins which have the same functions with CAST. You can find most of the proteins on our site.

Function Related Protein
calcium-dependent cysteine-type endopeptidase inhibitor activity
endopeptidase inhibitor activityCAST;SPINK2;SPINT2;MUG1;CST7;STFA1;USP14;SERPIND1;C5
poly(A) RNA bindingMTHFSD;YTHDC2;PRPF4B;RBPMS;PUM2;CPSF4;DNM1;MRPL32;CRKL
protease bindingADRM1;CCDC71L;DVL3;SERPINB3;SERPINA1E;STIM1;ITGAV;SERPINA1D;FN1
protein bindingTULP3;BRIP1;BRD3;LEPR;CDH1;BLOC1S4;PRL;APEH;CIB4

CAST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAST here. Most of them are supplied by our site. Hope this information will be useful for your research of CAST.

q9z305_cavpo; ABL1; FYN; SRC; NCK1; CAPN2; PLCG1; PIK3R1; CRK; GRB2; Kif13b; CAPN1; BAG6

Mahmoud, GA; Zayed, HS; et al. Renal outcomes among Egyptian lupus nephritis patients: a retrospective analysis of 135 cases from a single centre. LUPUS 24:331-338(2015).
Langdon, BB; Mirhossaini, RB; et al. Single-Molecule Resolution of Protein Dynamics on Polymeric Membrane Surfaces: The Roles of Spatial and Population Heterogeneity. ACS APPLIED MATERIALS & INTERFACES 7:3607-3617(2015).
  • Q&As
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