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CBLL1

Official Full Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Overview

This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
Synonyms

CBLL1; Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; E3 ubiquitin-protein ligase Hakai; Casitas B lineage lymphoma like; FLJ23109; HAKAI; RNF188; c-Cbl-like protein 1; Casitas B-lineage lymphoma transforming sequence-like protein 1; Casitas B-lineage lymphoma-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; HAKAI_HUMAN; RING finger protein 188; OTTHUMP00000206719; OTTHUMP00000206720; OTTHUMP00000206722; OTTHUMP00000206724; E-cadherin binding protein E7;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CBLL1-0462H	Recombinant Human CBLL1 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CBLL1-10758H	Recombinant Human CBLL1, GST-tagged	E.coli	GST	4-240a.a.	$319 / 25ug
Human	CBLL1-7813HCL	Recombinant Human CBLL1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CBLL1-2770HF	Recombinant Full Length Human CBLL1 Protein, GST-tagged	In Vitro Cell Free System	GST	491 amino acids	Inquiry
Mouse	CBLL1-2781M	Recombinant Mouse CBLL1 Protein	Mammalian Cell	His		Inquiry
Mouse	CBLL1-1264M-B	Recombinant Mouse CBLL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CBLL1-1264M	Recombinant Mouse CBLL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	CBLL1-639R	Recombinant Rhesus monkey CBLL1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CBLL1-467R	Recombinant Rhesus Macaque CBLL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	CBLL1-467R-B	Recombinant Rhesus Macaque CBLL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CBLL1-11292Z	Recombinant Zebrafish CBLL1	Mammalian Cell	His		Inquiry
Chicken	CBLL1-1773C	Recombinant Chicken CBLL1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CBLL1 Related Articles

CBLL1 involved in several pathways and played different roles in them. We selected most pathways CBLL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CBLL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CBLL1 has several biochemical functions, for example, identical protein binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBLL1 itself. We selected most functions CBLL1 had, and list some proteins which have the same functions with CBLL1. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	PDCD6;APLP1;FTL;Serpina1b;DYNLT1C;WRNIP1;TLE1;MAPK1IP1;ESYT2
ligase activity	GLULC;UBE2IB;RC3H2;RNF182;TRIM63;HUWE1;RCHY1;SMURF1;SIAH1A
protein binding	CA2;GOLGA2;UBXN4;TA;PLEKHN1;IFITM3;PILRB;SLC40A1;CLDN8
ubiquitin protein ligase activity	UBE2KB;MED7;FBXO30;CCNB1IP1;MED20;MARCH8;BFAR;MED21;RFFL
ubiquitin-protein transferase activity	LNX1;LMO7;CDC34;SIAH2L;NSMCE1;TRIM32;CBL;UBE2T;UBE2E3
zinc ion binding	ZCWPW2;JADE1;TRIM37;LMO1;TTF2;FBXO30;ADAM30;LTA4H;Ar

CBLL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBLL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBLL1.

CDH1; YWHAZ; q81kb5_bacan; SRC; KIF26B

Cao, MH; Zheng, HY; et al. Upregulation of CBLL1 in rat brain cortex after lipopolysaccharide treated. JOURNAL OF MOLECULAR HISTOLOGY 44:135-145(2013).

Oshida, K; Maeda, A; et al. Novel gene markers of immunosuppressive chemicals in mouse lymph node assay. TOXICOLOGY LETTERS 205:79-85(2011).