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WISP1

  • Official Full Name

    WNT1 inducible signaling pathway protein 1

  • Overview

    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
  • Synonyms

    WISP1; WNT1 inducible signaling pathway protein 1; CCN4; WISP1c; WISP1i; WISP1tc; WNT1-inducible-signaling pathway protein 1; CTC-458A3.8; CCN family member 4; WNT1 induced secreted protein 1; Wnt-1 inducible signaling pathway protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WISP1-1077H Active Recombinant Human WISP1 Protein, His-tagged Mammalian cells His Thr23-Asn367
Human WISP1-562H Active Recombinant Human WNT1 Inducible Signaling Pathway Protein 1 E.coli N/A
Human WISP1-2332H Recombinant Human WISP1 protein, His-tagged HEK293 His Met1-Asn367
Human WISP1-1699H Recombinant Human WNT1 Inducible Signaling Pathway Protein 1 Mammalian cells N/A
Human WISP1-308HCL Recombinant Human WISP1 293 Cell Lysate HEK293 N/A
Human WISP1-2820HCL Recombinant Human WISP1 cell lysate Human Cell N/A
Human WISP1-4309H-B Recombinant Human WISP1 Protein Pre-coupled Magnetic Beads HEK293
Human WISP1-592H Recombinant Human WISP1 Protein, His-tagged E.coli His Cys216~Arg347
Human WISP1-4309H Recombinant Human WISP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Wisp1-980M Active Recombinant Mouse Wisp1 Protein, His-tagged Mammalian cells His Thr23-Asn367
Mouse WISP1-18555M Recombinant Mouse WISP1 Protein Mammalian Cell His
Mouse Wisp1-10184M-B Recombinant Mouse Wisp1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Wisp1-593H Recombinant Mouse Wisp1 Protein, His-tagged E.coli His Tyr213~Asn350
Mouse Wisp1-10184M Recombinant Mouse Wisp1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat WISP1-6594R Recombinant Rat WISP1 Protein Mammalian Cell His
Rat WISP1-6250R-B Recombinant Rat WISP1 Protein Pre-coupled Magnetic Beads HEK293
Rat WISP1-6250R Recombinant Rat WISP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken WISP1-2184C Recombinant Chicken WISP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WISP1 Related Articles
  • WISP1 Related Research Area

WISP1 involved in several pathways and played different roles in them. We selected most pathways WISP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WISP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

WISP1 has several biochemical functions, for example, heparin binding, insulin-like growth factor binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WISP1 itself. We selected most functions WISP1 had, and list some proteins which have the same functions with WISP1. You can find most of the proteins on our site.

Function Related Protein
heparin bindingTHBS2;CCL5;HSD17B12;LPL;FGF2;ZNF207;POSTN;SMOC2;LIPC
insulin-like growth factor bindingKAZALD2;IGFALS;CTGF;IGFBP6A;IGFBP2B;HTRA3A;KAZALD1;CYR61L1;WISP2
integrin bindingWISP2;VWF;ACTN2;THBS1;WISP3;FAP;PTPN2;TIMP2;SYK

WISP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WISP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WISP1.

UGGT1

Klinke, DJ; et al. Induction of Wnt-Inducible Signaling Protein-1 Correlates with Invasive Breast Cancer Oncogenesis and Reduced Type 1 Cell-Mediated Cytotoxic Immunity: A Retrospective Study. PLOS COMPUTATIONAL BIOLOGY 10:-(2014).
Yang, MJ; Zhao, X; et al. A role for WNT1-inducible signaling protein-1 in airway remodeling in a rat asthma model. INTERNATIONAL IMMUNOPHARMACOLOGY 17:350-357(2013).
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