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CCNE2

Official Full Name

cyclin E2
Overview

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.
Synonyms

CCNE2; cyclin E2; G1/S-specific cyclin-E2; CYCE2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CCNE2-10864H	Recombinant Human CCNE2, GST-tagged	E.coli	GST	1-374a.a.	$319 / 25ug
Human	CCNE2-0667H	Recombinant Human CCNE2 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CCNE2-2918H	Recombinant Human Cyclin E2, T7-tagged	E.coli	T7		Inquiry
Human	CCNE2-180H	Recombinant Human CCNE2 protein, GST-tagged	Insect Cell	GST		Inquiry
Human	CCNE2-7709HCL	Recombinant Human CCNE2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CCNE2-2774H	Recombinant Human CCNE2 protein, His-tagged	E.coli	His	1-141 aa	$319 / 25ug
Human	CCNE2-2972HF	Recombinant Full Length Human CCNE2 Protein, GST-tagged	In Vitro Cell Free System	GST	374 amino acids	Inquiry
Human	CCNE2-3047H	Recombinant Human CCNE2 protein, His-tagged	E.coli	His	1-374 aa	$319 / 25ug
Zebrafish	CCNE2-307Z	Recombinant Zebrafish CCNE2	Mammalian Cell	His		Inquiry
Chicken	CCNE2-2634C	Recombinant Chicken CCNE2	Mammalian Cell	His		Inquiry

CCNE2 involved in several pathways and played different roles in them. We selected most pathways CCNE2 participated on our site, such as Cell cycle, Oocyte meiosis, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	DYRK1A;YWHAQ;SYNE1;ARF1;E2F2;ORC6;INCENP;HTATIP;SKA2
Oocyte meiosis	SMC3;CCNE1;CPEB1B;CALM;CPEB1A;ITPR1;CAMK2G1;CDC26;INSB
p signaling pathway	TNFRSF10B;CYCS;BIDA;LRDD;Casp3;SHISA5;PTENA;CASP9;CCNG1
PIK-Akt signaling pathway	G6PC;IL6R;Fgf15;HSP90B1;PKN2;IL2RG;ITGA5;IFNA17;PDGFC
Hepatitis B	IFNA8;CCNA2;IFNA12;PIK3R2;IKBKG;SRC;RAF1;BIRC5;FADD
Measles	EIF3H;NFKBIA;IFIH1;PIK3R1;EIF2AK3;RAB9A;HSPA1A;RAB9B;CCNE2
Pathways in cancer	PLCB4;BID;MMP1A;AXIN1;LPAR3;FGF19;WNT2B;CDH1;LPAR6
Viral carcinogenesis	HIST1H4J;HIST2H4;CREB3L1;HLA-C;DLG1;TP53;MAPKAPK2;HIST1H2BD;GTF2A1L
MicroRNAs in cancer	Abcb1b;NOTCH4;CYP24A1;STMN1;PDGFRB;PIM1;TRP53;APC;ERBB2
Prostate cancer	MAPK3;NRAS;PTEN;PIK3CG;SMARCD1;RELA;HSP90AA1;INS2;AKT1
Small cell lung cancer	RARB;ITGA6;PIK3CG;IKBKB;PIK3R5;PIK3CB;TP53;ITGA2B;BIRC8

CCNE2 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNE2 itself. We selected most functions CCNE2 had, and list some proteins which have the same functions with CCNE2. You can find most of the proteins on our site.

Function	Related Protein
cyclin-dependent protein serine/threonine kinase regulator activity	CCNL1;CCNK;CCND1;CCNE2;PSTPIP2;CCNT2;CCNC;CCNE1;CCNY
protein binding	BIN1;CLIP4;SBNO2;KIF1B;UQCC2;STOML2;ZNHIT1;GAN;CCDC9
protein kinase binding	FGR;PLK1S1;CDK5R1;YWHAZ;DUSP3;MAML1;TRAF6;ELAVL1;FER

CCNE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNE2.

CDK2; CDKN1A; CDKN1B; RBL2; ORC3; E7; CDKN1C; CDK3

Du, HY; Jie, LG; et al. A Monoclonal Antibody Against a Potential Cancer Biomarker, Human Ubiquitin-Conjugating Enzyme E2. HYBRIDOMA 31:196-202(2012).

Nair, BC; Nair, SS; et al. Cyclin-Dependent Kinase-Mediated Phosphorylation Plays a Critical Role in the Oncogenic Functions of PELP1. CANCER RESEARCH 70:7166-7175(2010).

Cyclins