MCM2
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Official Full Name
minichromosome maintenance complex component 2
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Overview
The MCM2 protein (minichromosome maintenance protein 2) is a 120 kD member of the MCM family that forms a heterotetramer with other family members. This nuclear protein functions in eukaryotic genome replication. MCM2 forms a complex with MCM4, MCM6, and -
Synonyms
MCM2; minichromosome maintenance complex component 2; CCNL1, CDCL1, MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) , minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin); DNA replication licensing factor MCM2; BM28; cdc;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | MCM2-28039TH | Recombinant Human MCM2, His-tagged | E.coli | His |
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| Human | MCM2-4420HCL | Recombinant Human MCM2 293 Cell Lysate | HEK293 | N/A |
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| Human | MCM2-3212H | Recombinant Human MCM2 protein, His-tagged | E.coli | His | 2-904aa |
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| Human | MCM2-4518H | Recombinant Human MCM2 Protein (Phe657-Phe904), N-His tagged | E.coli | N-His | Phe657-Phe904 |
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| Mouse | MCM2-9634M | Recombinant Mouse MCM2 Protein | Mammalian Cell | His |
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| Mouse | MCM2-5410M | Recombinant Mouse MCM2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | MCM2-5410M-B | Recombinant Mouse MCM2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | MCM2-9530Z | Recombinant Zebrafish MCM2 | Mammalian Cell | His |
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| Chicken | MCM2-1291C | Recombinant Chicken MCM2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- MCM2 Related Articles
- MCM2 Related Research Area
MCM2 involved in several pathways and played different roles in them. We selected most pathways MCM2 participated on our site, such as DNA replication, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA replication | PRIM1;CDT1;RFC2;LIG1;MCM5;RFC5;SSBP1;POLD4;RPA2 |
| Cell cycle | SETB;GINS1;MAU2;DULLARD;CDC25A;BORA;ORC1L;CENPW;NDE1 |
MCM2 has several biochemical functions, for example, ATP binding, DNA binding, DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM2 itself. We selected most functions MCM2 had, and list some proteins which have the same functions with MCM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACTG2;WEE1;MYLK2;RPS6KA1;NDUFA13;CDK3;EPHA3;KHK;ATP2A2B |
| DNA binding | TNP1;CLSPN;ADNP2;MYRFL;MXD4;HIST1H3F;HIF1AL2;NUP153;SSRP1 |
| DNA helicase activity | RECQL5;DNA2;WRN;PEO1;MCM6L;ATRX;CHD8;FBXO18;MCM3L |
| DNA replication origin binding | MCM10;CDC45;ORC2L;MCM2;MCM5;ORC4L;HSPD1;ORC3L;ORC4 |
| histone binding | HINFP;PRMT7;SPTY2D1;MYSM1;UHRF1;HJURP;NCAPD3;ATAD2;HAT1 |
| metal ion binding | CYP2C38;HARBI1;KCNMA1;ZNF672;GUCA1D;AOX4;ZNF573;FDPS;ARIH1L |
| protein binding | TYRO3;TCEB1;RHOXF2;SPC24;SLC25A5;NIPA2;PHB;ATXN7L1;RNF111 |
MCM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM2.
MCM6; MCM7
- Q&As
- Reviews
Q&As (7)
Ask a questionMCM2 is a key component of the pre-replication complex, essential for initiating DNA replication.
MCM2 plays a critical role in cell cycle progression, particularly at the DNA synthesis phase.
Altered MCM2 activity can compromise genome integrity and lead to genomic instability.
MCM2 collaborates with other replication proteins to ensure efficient and accurate DNA replication.
It helps in unwinding the DNA helix, allowing replication machinery to access DNA strands.
Targeting MCM2 in cancer therapy could disrupt aberrant cell proliferation.
Genetic mutations in MCM2 can lead to replication errors and cell cycle dysregulation.
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