cdkl5
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  • Official Full Name
  • cyclin-dependent kinase-like 5
  • Background
  • This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CDKL5; cyclin-dependent kinase-like 5; ISSX; STK9; EIEE2; serine/threonine kinase 9; serine/threonine-protein kinase 9; cyclin dependent kinase 5 transcript;
Cat.#:CDKL5-1052HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDKL5 Protein, GST-Tagged
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Cat.#:CDKL5-11060HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKL5, GST-tagged
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Cat.#:CDKL5-7022HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STK9, GST-tagged
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Cat.#:CDKL5-7131ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDKL5
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Cat.#:CDKL5-7388ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDKL5
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Involved Pathway

CDKL5 involved in several pathways and played different roles in them. We selected most pathways CDKL5 participated on our site, such as BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
CDK5; EIF4EBP1; CNR1; JAK2; DOK5; GRIP1; DPYSL2; EIF4E; MAP3K2; EIF2S1

Protein Function

CDKL5 has several biochemical functions, for example, ATP binding, Rac GTPase binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKL5 itself. We selected most functions CDKL5 had, and list some proteins which have the same functions with CDKL5. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDKL1; ERCC2; CFTR; CNTN1B; AURKB; CHD8; MYLK; FYNA; UBE2D3; VMHCL
Function Rac GTPase binding
Related Protein NOXA1; PAK3; RCC2; DVL1; CORO1C; CDKL5; SRGAP2A; NCF2; SRGAP2B; PAK7
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein STK30; CDKL4; CDK16; CDK2; CDK4; CDK20; CDK1; CDK5R1; CDK10; MOK
Function kinase activity
Related Protein PINK1; DYRK1AA; MAPK8A; PIK3CA; MAP3K12; PIK3R3B; LMTK3; MAP2K4A; PI4KAA; BAIAP2L1A
Function protein kinase activity
Related Protein MMD; HIPK3B; SRPK1; OXSR1A; IGF1RA; DAPK1; STK30; CLK4B; TLK1A; SCYL2
Function protein serine/threonine kinase activity
Related Protein CDC42BPG; NEK12; MAPK12A; BMPR2A; RPS6KC1; CDK11B; SMOK3B; AAK1; DYRK3; CDKL5

Interacting Protein

CDKL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKL5.
Dlg4; ABL1; FYN; GRB2; PRKG2; SKIV2L