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CDT1

  • Official Full Name

    chromatin licensing and DNA replication factor 1

  • Overview

    The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
  • Synonyms

    CDT1; chromatin licensing and DNA replication factor 1; DUP; RIS2; DNA replication factor Cdt1; Double parked, Drosophila, homolog of;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDT1-11073H Recombinant Human CDT1, GST-tagged E.coli GST 195-546a.a.
Human CDT1-27915TH Recombinant Human CDT1, His-tagged E.coli His
Human CDT1-105H Recombinant Human CDT1 protein, GST-tagged Wheat Germ GST 1 a.a. - 546 a.a.
Human CDT1-7604H Recombinant Human CDT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CDT1-7604HCL Recombinant Human CDT1 293 Cell Lysate HEK293 N/A
Human CDT1-9663HFL Recombinant Full Length Human CDT1 protein, Flag-tagged Mamanlian cells Flag
Human CDT1-575HF Recombinant Full Length Human CDT1 Protein, GST-tagged In Vitro Cell Free System GST 546 amino acids
Mouse CDT1-3240M Recombinant Mouse CDT1 Protein Mammalian Cell His
Mouse CDT1-1550M Recombinant Mouse CDT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDT1-1550M-B Recombinant Mouse CDT1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDT1 Related Articles

CDT1 involved in several pathways and played different roles in them. We selected most pathways CDT1 participated on our site, such as Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Association of licensing factors with the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of the pre-replicative complexCDK2;DBF4;CDT1;MCM8;MCM10
Assembly of the pre-replicative complexE2F1;E2F3;E2F2;CDT1;MCM8;GMNN
Association of licensing factors with the pre-replicative complexE2F3;E2F1;CDT1;E2F2;GMNN
CDT1 association with the CDC6:ORC:origin complexMCM8;GMNN;CDT1
Cell CycleH3F3D;UIMC1;WEE2;TMEM188;AKAP9;CEP63;SETB;GMNN;CCNB3
Cell Cycle, MitoticNCAPG;SGOL1;ENSA;CKS1B;BORA;NDC80;BLZF1;LIN37;CEP76
DNA ReplicationSSBP1;GMNN;POLE4;LIG1;GINS4;RNASEH2C;GINS2;POLD1;RPA2
DNA Replication Pre-InitiationGMNN;DBF4;CDT1;MCM10

CDT1 has several biochemical functions, for example, DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDT1 itself. We selected most functions CDT1 had, and list some proteins which have the same functions with CDT1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingIGHMBP2;TERFA;TBX22;ZFP28;SALL1;MYCN;NKX2.7;ELK4;GLYR1
protein bindingERCC1;RNF216;PTPN14;PGRMC1;RABEP1;PROP1;ZNF624;PEG10;POU2AF1

CDT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDT1.

GMNN; MCM6; CDK2; CDC6

Kroeger, PT; Shoue, DA; et al. Knockdown of SCFSkp2 Function Causes Double-Parked Accumulation in the Nucleus and DNA Re-Replication in Drosophila Plasmatocytes. PLOS ONE 8:-(2013).
Yanagita, E; Kamoshida, S; et al. Immunohistochemistry-based Cell Cycle Detection (iCCD): A Novel System to Visualize Cell Kinetics on Formalin-fixed Paraffin-embedded Tissues. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 36:769-773(2012).
  • Q&As
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