CEBPA
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Official Full Name
CCAAT/enhancer binding protein (C/EBP), alpha
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Overview
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. -
Synonyms
CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha; CEBP; CCAAT/enhancer-binding protein alpha; C/EBP alpha; C/EBP-alpha;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CEBPA involved in several pathways and played different roles in them. We selected most pathways CEBPA participated on our site, such as Acute myeloid leukemia, Adipogenesis, C-MYB transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEBPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acute myeloid leukemia | PIK3CD;PIK3CA;STAT5A;RELA;ZBTB16;JUP;PML;NFKB1;PIK3CB |
| Adipogenesis | EGR2;KLF6A;CYP26A1;BMP1;BMP3;NR2F1A;KLF7A;MBNL1;PLIN2 |
| C-MYB transcription factor network | SKI;MYF6;ADORA2B;PIAS3;CSF1R;TOM1;PPID;MYB;PRTN3 |
| Developmental Biology | CDK5R1B;PLXND1;TCF4;CSNK2B;WDR83;RASGRP1;EFNA2A;MYL12A;NRG3 |
| E2F transcription factor network | E2F4;E2F6;CES5A;YY1;HBP1;MYBL2;TRIM28;PRMT5;CEBPA |
| EGFR1 Signaling Pathway | RALBP1;PTK6;PITPNA;RBBP7;GRB7;WNK1;PLSCR1;KRT7;TNK2 |
| FOXA2 and FOXA3 transcription factor networks | CEBPA;FOXF1;KCNJ11;DLK1;CPT1C;UCP2;CPT1B;TTR;FOXA1 |
| Non-alcoholic fatty liver disease (NAFLD) | BAX;BID;MAP3K5;UQCRB;COX6B2;NDUFB3;AKT1;NDUFA6;DDIT3 |
CEBPA has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase I regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CEBPA itself. We selected most functions CEBPA had, and list some proteins which have the same functions with CEBPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | RBPJ;PML;POLR3F;SOX19A;NPAS1;ZNF404;NKX6.1;MSGN1;ZNF3 |
| HMG box domain binding | MEOX1;OLIG2;DLX5;PAX3;GATA3;POU3F3;ALX4;SP1;CEBPA |
| RNA polymerase I regulatory region DNA binding | |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | RBPJ;MED1;TFE3;DPF2;MEF2B;YBX1;FOXJ2;CEBPB;CTCFL |
| histone deacetylase binding | RELA;NKX2-5;YWHAB;BRMS1;HDAC1;NCOR1;MYOCD;KPNA2;NR2C1 |
| kinase binding | BARD1;HAP1;JAKMIP3;PARK2;PARK7;DLG1;WWC3;SGOL1;TAX1BP1 |
| protein binding | FDX1L;HSP90AB1;MLH1;C11orf54;SRSF10;MBP;ZNF114;AKT1S1;NUDT1 |
| protein complex binding | NCOA1;ERCC8;LRP1;NOG;EPCAM;CTSL2;ING2;VHLL;CDK4 |
| protein heterodimerization activity | NFYBB;PRMT8;MYOG;KCNH5;HIST1H2AB;AOC3;H2AFV;EXT2;TIMELESS |
| protein homodimerization activity | TBX18;FZD9;PDXK;PSPH;KCNH2;VEGFA;ZFP365;P2RX7;DPY30 |
| transcription coactivator activity | CTNNB1;SMARCB1;JUNB;YY1;MED26;BIRC2;CITED1;WWC1;MYOCD |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SFPI1;MYF5;T;PURA;FOXC2;FOXF2A;JUN;ATF2;SPI1 |
| transcription factor activity, sequence-specific DNA binding | ZHX2;SALL1;HSF4;MGAA;DLX6;ZNF234;HOXC4A;ZNF232;GATAD1 |
| transcription factor binding | H2-AB1;PAXBP1;HDAC5;DIP2A;BPTF;TAF7L;MYC;RPS3;MAPK1 |
| transcription regulatory region DNA binding | GABPA;TAF7;NKX2-5;MTERFD1;HDAC1;CTCFL;IKZF1;FOXA1;NKX2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GLI3;MYC;NFIB;ETV2;NRL;PGR;SFPI1;TCF4;NR2E1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAFB;MSGN1;GATA6;AIRE;ONECUT3;MYOCD;FOXO3;FOXF1;HSF2 |
CEBPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEBPA here. Most of them are supplied by our site. Hope this information will be useful for your research of CEBPA.
E2; IL32; CDX1; E2; PARP1; E2; CEBPB
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