CEBPE
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Official Full Name
CCAAT/enhancer binding protein (C/EBP), epsilon
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Overview
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. -
Synonyms
CEBPE; CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer-binding protein epsilon; CRP1; c/EBP epsilon; C/EBP-epsilon;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CEBPE involved in several pathways and played different roles in them. We selected most pathways CEBPE participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEBPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | RARA;MAF;SMAD1;PAX3;IL6;HOXA9;CCND2;RUNX1;MAX |
CEBPE has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein heterodimerization activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CEBPE itself. We selected most functions CEBPE had, and list some proteins which have the same functions with CEBPE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ETV4;TCF3A;ESRRA;ZNF100;NFATC2;SREBF2;ZNF543;CTCFL;ARNT2 |
| protein heterodimerization activity | KCNN1;HIST2H2AC;PIK3R1;PPP1CBL;IL12A;TENM1;MAFGA;BCL2A1;SRI |
| protein homodimerization activity | DMRTB1;RQCD1;ANO2;TARS;DEM1;SLC22A6;MFF;CSF1R;CCBL1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ESRRA;HOXA5;POU4F1;MEF2C;TRP53;EBF3A;OTX2;RELA;GRHL1 |
CEBPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEBPE here. Most of them are supplied by our site. Hope this information will be useful for your research of CEBPE.
HSP90AB1; DOCK1; a8k673_human; CSNK1A1L; GPR22; CCT7; EDA2R; PSAT1
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