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CENPA

  • Official Full Name

    centromere protein A

  • Overview

    Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
  • Synonyms

    CENPA; centromere protein A; Cenp-A; histone H3-like centromeric protein A; centrosomin A; centromere autoantigen A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CENPA-617H Recombinant Human Centromere Protein A, His-tagged Sf9 Insect Cell His
Human CENPA-27391TH Recombinant Human CENPA, His-tagged His
Human CENPA-1111H Recombinant Human CENPA Protein, GST-Tagged Wheat Germ GST
Human CENPA-7586HCL Recombinant Human CENPA 293 Cell Lysate HEK293 N/A
Human CENPA-7587HCL Recombinant Human CENPA 293 Cell Lysate HEK293 N/A
Human CENPA-3313HF Recombinant Full Length Human CENPA Protein, GST-tagged In Vitro Cell Free System GST 114 amino acids
Human CENPA-572HFL Recombinant Full Length Human CENPA Protein, C-Flag-tagged Mammalian cells Flag
Human CENPA-6623H Recombinant Human CENPA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CENPA-575H Recombinant Human CENPA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CENPA-301526H Recombinant Human CENPA protein, GST-tagged E.coli GST Met1-His59
Human CENPA-575H-B Recombinant Human CENPA Protein Pre-coupled Magnetic Beads HEK293
Mouse CENPA-3281M Recombinant Mouse CENPA Protein Mammalian Cell His
Mouse CENPA-1575M Recombinant Mouse CENPA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CENPA-1359M Recombinant Mouse CELA2A Protein (1-134 aa), His-tagged Yeast His 1-134 aa
Mouse Cenpa-877M Recombinant Mouse Cenpa Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CENPA-1575M-B Recombinant Mouse CENPA Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CENPA-7573Z Recombinant Zebrafish CENPA Mammalian Cell His
Chicken CENPA-3735C Recombinant Chicken CENPA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CENPA Related Articles

CENPA involved in several pathways and played different roles in them. We selected most pathways CENPA participated on our site, such as Aurora A signaling, Aurora B signaling, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aurora A signalingCENPA;AURKB;GADD45A;TACC1;TPX2;AURKAIP1;NDEL1;TDRD7;TACC3
Aurora B signalingSMC4;KIF20A;SGOL1;NCAPD2;EVI5;NPM1;CDCA8;INCENP;PEBP1
Cell CycleORC4L;CLIP1;SMC1B;BARD1;CENPE;MCM6L;SMC3;CEP152;ANAPC5
Cell Cycle, MitoticNDC80;NDE1;NUDC;CLIP1;DCTN3;INCENP;CDK4;FOXM1;KNTC1
Chromosome MaintenanceCENPK;CENPO;RBBP7;OIP5;MLF1IP;PANE1;DKC1;CENPH;CENPW
Deposition of new CENPA-containing nucleosomes at the centromereRBBP4;APITD1;CENPO;CENPI;CENPH;MIS18A;CENPN;CENPP;HJURP
FOXM1 transcription factor networkAURKB;CENPA;CHEK2;CKS1B;CENPB;FOXM1
M PhasePDS5A;INCENP;NCAPG2;ZW10;KIF2A;KNTC1;NCAPD3;NIPBL;CENPQ

CENPA has several biochemical functions, for example, DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPA itself. We selected most functions CENPA had, and list some proteins which have the same functions with CENPA. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHIST1H2AM;ZFP36L3;RUNX2B;PPP1R8;STAT3;ZNF225;MSXB;JUNBB;HOXB4A
chromatin bindingTFAM;SSBP1;SIRT7;TCF3;CRTC2;KLHDC3;SREBF1;OST4;MORF4L1
protein bindingPRKCQ;FAM101A;INPP4B;RAB33B;PINX1;KRR1;POLE3;C10orf28;ZKSCAN17
protein heterodimerization activityBAD;SYT14;HGF;FLOT1;PPP2R1A;PPP3CA;HIST3H3;HIST1H4E;PDGFA

CENPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPA here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPA.

HJURP; HIST2H4B; NPM1

Low, AHL; Wong, S; et al. Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population. RHEUMATOLOGY 51:1465-1470(2012).
Francis, GD; Stein, SR; et al. Prediction of histologic grade in breast cancer using an artificial neural network. 2012 INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS (IJCNN) :-(2012).
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