cenpa
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  • Official Full Name
  • centromere protein A
  • Background
  • Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
  • Synonyms
  • CENPA; centromere protein A; Cenp-A; histone H3-like centromeric protein A; centrosomin A; centromere autoantigen A;
Cat.#:CENPA-1359MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse CELA2A Protein (1-134 aa), His-tagged
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Cat.#:CENPA-1111HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CENPA Protein, GST-Tagged
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Cat.#:CENPA-27391THTag:His
Source (Host):Species:Human
Product nameRecombinant Human CENPA, His-tagged
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Cat.#:CENPA-3281MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CENPA Protein
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Cat.#:CENPA-3735CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CENPA
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Cat.#:CENPA-7573ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CENPA
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Cat.#:CENPA-617HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Centromere Protein A, His-tagged
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Cat.#:CENPA-7586HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CENPA 293 Cell Lysate
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Cat.#:CENPA-7587HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CENPA 293 Cell Lysate
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Involved Pathway

CENPA involved in several pathways and played different roles in them. We selected most pathways CENPA participated on our site, such as Aurora A signaling, Aurora B signaling, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aurora A signaling
CENPA; TACC1; TACC3; AURKAIP1; GADD45A; AURKB; OAZ1; TPX2; NDEL1; TDRD7
Aurora B signaling
INCENP; CENPA; NPM1; NCAPD2; KIF20A; SGOL1; CDCA8; NCAPH; SEPT1; SMC4
Cell Cycle
CENPK; FAM175A; CKAP5; MAD2L2; SGOL1; DYNC1H1; TGFB3; SMAD3B; SKP1; CDKN2B
Cell Cycle, Mitotic
ARPP19A; DYNC1I2; NUDC; SGOL2; CENPP; ENSAB; MAPRE1A; NDE1; CDKN2C; PMF1
Chromosome Maintenance
MIS18BP1; OIP5; RBBP7; APITD1; POT1; RUVBL2; ITGB3BP; CENPL; PANE1; CENPK
Deposition of new CENPA-containing nucleosomes at the centromere
MLF1IP; RBBP7; CENPC1; OIP5; MIS18A; CENPL; MIS18BP1; HJURP; CENPI; CENPK
FOXM1 transcription factor network
FOXM1; CENPB; AURKB; CKS1B; CHEK2; CENPA
M Phase
SGOL2; SGOL1; SPC24; PDS5A; NCAPG2; APITD1; DSN1; STAG1; ANKLE2; NCAPD3

Protein Function

CENPA has several biochemical functions, for example, DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPA itself. We selected most functions CENPA had, and list some proteins which have the same functions with CENPA. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RFX8; THOC1; EEF1D; TP63; THAP10; DNA2; JRKL; RTEL1; TOX; ZHX2
Function chromatin binding
Related Protein CUX1; SMAD6; HMGXB4A; CHD7; CENPB; NKX6; PRKCBP1L; PAX3; HOXC13; BRD4
Function protein binding
Related Protein NOL6; FBXO5; ATP2A2; LGALS3; CTC1; C19orf73; SH2D1B; PSMD9; PCDH18; FYTTD1
Function protein heterodimerization activity
Related Protein IRAK1; BCL2; AHR; SOX15; HIST1H2AI; TENM2; ADRB1; HIST2H2AA4; TYR; SOX4

Interacting Protein

CENPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPA here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPA.
HJURP; HIST2H4B; NPM1

CENPA Related Articles

Low, AHL; Wong, S; et al. Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population. RHEUMATOLOGY 51:1465-1470(2012).
Francis, GD; Stein, SR; et al. Prediction of histologic grade in breast cancer using an artificial neural network. 2012 INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS (IJCNN) :-(2012).