CERK
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Official Full Name
ceramide kinase
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Overview
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated;in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006;(PubMed 16488390)). -
Synonyms
CERK; ceramide kinase; dA59H18.2; dA59H18.3; DKFZp434E0211; FLJ21430; FLJ23239; hCERK; KIAA1646; LK4; lipid kinase 4; lipid kinase LK4; acylsphingosine kinase; MGC131878;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
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- In Vitro Cell Free System
- Insect Cell
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- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CERK involved in several pathways and played different roles in them. We selected most pathways CERK participated on our site, such as Sphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CERK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | PPAP2C;PPAP2B;ASAH1;GLA;SGMS2;CERS2;COL4A3BP;SGPL1;SPTLC3 |
CERK has several biochemical functions, for example, ATP binding, ceramide kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CERK itself. We selected most functions CERK had, and list some proteins which have the same functions with CERK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP9B;OASL1;STK17B;NLRP9B;TP53;MAK;TARSL2;CSNK1G3;VPS4B |
| ceramide kinase activity | AGK;CERK |
| magnesium ion binding | NUAK2;PRPSAP1;FEN1;LHPP;MARK2;GCLC;WEE1;SNCA;PPA1B |
| protein binding | WDYHV1;SUV39H1;RTDR1;ANKRD54;CBX1;EFHC1;DCTN1;HOXA10;PSMA4 |
CERK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CERK here. Most of them are supplied by our site. Hope this information will be useful for your research of CERK.
ALAS1; MTUS2; NOTCH2NL; WDR46; GEMIN2; PRPF4; BUB1B; USP1; NR3C1; UBL4A; U2AF2
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