Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

Ces2c

Official Full Name

carboxylesterase 2C
Overview

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. The transcription of this gene is regulated by several factors including HNF-4alpha (hepatocyte nuclear factor-4alpha), Sp1 (specificity protein 1), Sp3 and USF1 (upstream stimulatory factor 1). The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with several family members including a few of pseudogenes and Ces5 on chromosome 8.
Synonyms

Ces2c; carboxylesterase 2C; Ces2; ces2A3; carboxylesterase 2; carboxylesterase ML3; acylcarnitine hydrolase M1; EC 3.1.1.1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	Ces2c-911M	Active Recombinant Mouse Ces2c protein, His-tagged	HEK293	His	Met1-Lys557	$699 / 50 µg
Mouse	CES2C-3330M	Recombinant Mouse CES2C Protein	Mammalian Cell	His		Inquiry
Mouse	CES2-2199MCL	Recombinant Mouse CES2 cell lysate	Human Cell	N/A		Inquiry
Mouse	CES2C-1602M	Recombinant Mouse CES2C Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CES2C-1602M-B	Recombinant Mouse CES2C Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

Ces2c involved in several pathways and played different roles in them. We selected most pathways Ces2c participated on our site, such as Drug metabolism - other enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ces2c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Drug metabolism - other enzymes	IMPDH1;CES2;UCKL1;ITPA;UGT5G1;UGT1AB;XDH;UGT2A1;GMPS

Ces2c has several biochemical functions, for example, acylcarnitine hydrolase activity, carboxylic ester hydrolase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ces2c itself. We selected most functions Ces2c had, and list some proteins which have the same functions with Ces2c. You can find most of the proteins on our site.

Function	Related Protein
acylcarnitine hydrolase activity
carboxylic ester hydrolase activity	AADACL4;ACOT6;ACOT8;PNPLA7;LYPLA2;ABHD4;BAAT;Cel;Aadacl3
hydrolase activity	ADARB2;USB1;REN2;DUSP23B;MOV10B.1;PLCD1B;DDX39;CASP3A;URAH

Ces2c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ces2c here. Most of them are supplied by our site. Hope this information will be useful for your research of Ces2c.

Ywhae; Ywhaz; Hsd3b4; Hsd3b7