CHI3L1
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Official Full Name
chitinase 3-like 1 (cartilage glycoprotein-39)
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Overview
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] -
Synonyms
CHI3L1; chitinase 3-like 1 (cartilage glycoprotein-39); GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39; chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- CHO
- E.coli
- HEK293
- HEK293 cells
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Myc
- DDK
- Flag
- GST
- His (Fc)
- Avi
- His|Myc
- His|SUMO|Myc
- His|T7
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CHI3L1 Related Articles
- CHI3L1 Related Research Area
CHI3L1 involved in several pathways and played different roles in them. We selected most pathways CHI3L1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CHI3L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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CHI3L1 has several biochemical functions, for example, carbohydrate binding, chitin binding, NOT chitinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHI3L1 itself. We selected most functions CHI3L1 had, and list some proteins which have the same functions with CHI3L1. You can find most of the proteins on our site.
Function | Related Protein |
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carbohydrate binding | Chil3;LMAN2;GALNT13;OLR1;MBL1;GANAB;CLEC5A;KLRC2;LGALS9 |
chitin binding | CTBS;CHID1;Chil3;FIBCD1;CHIA.3;CHIT1;CHIA.1;CHIA.4;CHI3L1 |
NOT chitinase activity | CHI3L1;Chil3;CHI3L2 |
extracellular matrix structural constituent | COL11A1B;COL11A1A;COL2A1B;COL5A2;CD4;PXDN;MATN3;FBLN1;TFPI2 |
CHI3L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHI3L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHI3L1.
- Q&As
- Reviews
Q&As (6)
Ask a questionIn addition to being involved in cartilage metabolism and immune regulation, CHI3L1 may also have other modes of action, such as regulating cell adhesion and migration.
This protein can act as an immunomodulator to inhibit the inflammatory response and the activity of immune cells, thereby maintaining the balance of the immune system.
CHI3L1 can bind to receptors on the surface of chondrocytes, stimulate the proliferation and differentiation of chondrocytes, and promote cartilage synthesis and repair.
The expression level of CHI3L1 is regulated by a variety of factors, including transcription factors, signal transduction pathways, and epigenetic modifications.
In joint diseases such as rheumatoid arthritis, the expression level of CHI3L1 may be abnormally elevated, promoting inflammation and joint damage, and aggravating the condition.
The expression level of CHI3L1 can be detected by immunohistochemistry, western blotting, and real-time PCR.
Customer Reviews (3)
Write a reviewCHI3L1 has strong biological activity combined with its high purity makes its experimental results extremely reliable.
The band strength in Western blot was high, which improved the signal-to-noise ratio of the experiment.
It can simplify the complex chemical reaction and improve the high yield, shorten the experimental time.
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