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CHKB

Official Full Name

choline kinase beta
Overview

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.
Synonyms

CHKB; choline kinase beta; CHKL, choline kinase like; choline/ethanolamine kinase; CHETK; Chetk-beta; Chkb choline kinase beta; Chkb protein; CHKB_HUMAN; CHKL; Choline kinase-like; Choline kinase-like protein; choline/ethanolamine kinase beta; Choline/ethanolamine kinase, beta; CK; CK/EK; CK/EK-beta; CKB; CKEKB; EK; EKB; Ethanolamine kinase; Ethanolamine kinase beta; Ethanolamine kinase, beta; MDCMC;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
MYC
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CHKB-35H	Recombinant Human CHKB protein	E.coli	N/A	395aa	Inquiry
Human	CHKB-1243H	Recombinant Human CHKB Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CHKB-26715TH	Recombinant Human CHKB	Wheat Germ	N/A	395 amino acids	Inquiry
Human	CHKB-7534HCL	Recombinant Human CHKB 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CHKB-78HF	Recombinant Full Length Human CHKB Protein	In Vitro Cell Free System		395 amino acids	Inquiry
Human	CHKB-4578H	Recombinant Human CHKB Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CHKB-775H	Recombinant Human CHKB Protein, His-tagged	E.coli	N-His	Phe238-Ser395	Inquiry
Human	CHKB-3202HF	Recombinant Full Length Human CHKB Protein, GST-tagged	In Vitro Cell Free System	GST	395 amino acids	Inquiry
Mouse	CHKB-3399M	Recombinant Mouse CHKB Protein	Mammalian Cell	His		Inquiry
Mouse	CHKB-1645M	Recombinant Mouse CHKB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CHKB-1645M-B	Recombinant Mouse CHKB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Chkb-885M	Recombinant Mouse Chkb Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	Chkb-1726M	Recombinant Mouse Chkb protein, His-tagged	E.coli	His	Phe238~Ser394	Inquiry
Rat	CHKB-1374R	Recombinant Rat CHKB Protein	Mammalian Cell	His		Inquiry
Rat	CHKB-1032R-B	Recombinant Rat CHKB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	CHKB-1032R	Recombinant Rat CHKB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	CHKB-5818Z	Recombinant Zebrafish CHKB	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CHKB Related Articles
CHKB Related Research Area

CHKB involved in several pathways and played different roles in them. We selected most pathways CHKB participated on our site, such as Choline metabolism in cancer, Fatty Acid Beta Oxidation, Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Choline metabolism in cancer	RPS6KB2;DGKB;SLC22A2;PRKCA;HIF1A;Pdgfa&Pdgfb;LYPLA1;PIK3R5;TSC1
Fatty Acid Beta Oxidation	CPT1B;CPT2;CHKB;CRAT;ECI1;SLC25A20;DECR1;CPT1A
Glycerophospholipid biosynthesis	DGAT1B;AGPAT6;PLB1;CDS1;CPNE1;SLC44A5B;CEPT1;PLBD1;STIL
Glycerophospholipid metabolism	ETNPPL;PLA2G4AA;AGPAT1;AGPAT6;LYPLA2;DGKD;LPCAT1;CEPT1B;CHKA
Metabolic pathways	ACOT8;POC1B-GALNT4;CERS2A;SLC27A5;PIK3C2G;RDH11;ALAS2;GALM;MAN2A2
Metabolism	CYP8B2;OXSR1;ECI1;ACER1;NUBP1;PRKRA;LYRM4;SLC25A15A;FAAH2
Metabolism of lipids and lipoproteins	AGPAT6;CYP46A1;PPARGC1B;ANKRD1;SLC25A1;ALOX5B.3;CERS5;CDIPT;CYP4T8
Phospholipid metabolism	SACM1LA;ABHD3;AWAT1;SACM1LB;PNPLA8;DGAT1B;PITPNB;PEMT;CHKA

CHKB has several biochemical functions, for example, ATP binding, choline kinase activity, ethanolamine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHKB itself. We selected most functions CHKB had, and list some proteins which have the same functions with CHKB. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TTLL5;FAM20B;ABCB6;NADK;HLCS;TRAP1;MYO1A;PCCA;DDX56
choline kinase activity	CHKA;CHKB
ethanolamine kinase activity	ETNK2;CHKA;CHKB;ETNK1

CHKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHKB here. Most of them are supplied by our site. Hope this information will be useful for your research of CHKB.

ALB

Yang, L; Roh, YS; et al. Transforming Growth Factor Beta Signaling in Hepatocytes Participates in Steatohepatitis Through Regulation of Cell Death and Lipid Metabolism in Mice. HEPATOLOGY 59:483-495(2014).

Gruber, J; Too, WCS; et al. Balance of human choline kinase isoforms is critical for cell cycle regulation Implications for the development of choline kinase-targeted cancer therapy. FEBS JOURNAL 279:1915-1928(2012).

Fatty Acid Synthesis