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CHM

Official Full Name

choroideremia (Rab escort protein 1)
Overview

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms

CHM; choroideremia (Rab escort protein 1); DXS540, TCD; rab proteins geranylgeranyltransferase component A 1; REP 1; rab escort protein 1; choroideraemia protein; Rab geranylgeranyltransferase component A; TCD; GGTA; REP-1; DXS540; HSD-32; FLJ38564; MGC10;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Fish
Human
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CHM-1919H	Recombinant Human CHM Protein (1-653 aa), His-tagged	E.coli	His	1-653 aa	Inquiry
Rat	CHM-1375R	Recombinant Rat CHM Protein	Mammalian Cell	His		Inquiry
Rat	CHM-1033R	Recombinant Rat CHM Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CHM-1033R-B	Recombinant Rat CHM Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Fish	chm-726F	Active Recombinant Fish chm Protein	E.coli	N/A		Inquiry
Zebrafish	CHM-11577Z	Recombinant Zebrafish CHM	Mammalian Cell	His		Inquiry
Chicken	CHM-2791C	Recombinant Chicken CHM	Mammalian Cell	His		Inquiry

CHM Related Articles

CHM involved in several pathways and played different roles in them. We selected most pathways CHM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CHM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CHM has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CHM itself. We selected most functions CHM had, and list some proteins which have the same functions with CHM. You can find most of the proteins on our site.

Function	Related Protein

CHM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHM here. Most of them are supplied by our site. Hope this information will be useful for your research of CHM.

Bovet, J; Pineau-Vincent, F; et al. ADAMTS13 and thrombotic thrombocytopenic purpura Retrospective study at the hospital of Le Mans. ANNALES DE BIOLOGIE CLINIQUE 72:321-330(2014).

Miura, S; Kondo, J; et al. The N- Terminal Cleavage of Chondromodulin-I in Growth- Plate Cartilage at the Hypertrophic and Calcified Zones during Bone Development. PLOS ONE 9:-(2014).