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CHRNA3

  • Official Full Name

    cholinergic receptor, nicotinic, alpha 3

  • Overview

    This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
  • Synonyms

    CHRNA3; cholinergic receptor, nicotinic, alpha 3; cholinergic receptor, nicotinic, alpha polypeptide 3; NACHRA3; LNCR2; PAOD2; MGC104879; neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha3 subunit; OTTHUMP00000185024; OTTHUMP00000185025;

  • Recombinant Proteins
  • Chicken
  • Human
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • SUMO
  • Myc
  • N
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHRNA3-11211H Recombinant Human CHRNA3, GST-tagged E.coli GST 32-238a.a.
Human CHRNA3-1280H Recombinant Human CHRNA3 Protein, GST-Tagged Wheat Germ GST
Human CHRNA3-86H Recombinant Human CHRNA3, His-tagged E.coli His
Human CHRNA3-1723H Recombinant Human CHRNA3 Protein (Ser32-Leu240), N-His tagged E.coli N-His Ser32-Leu240
Human CHRNA3-2697H Recombinant Human CHRNA3 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 32-240aa
Human CHRNA3-2691H Recombinant Human CHRNA3 Protein (32-240 aa), His-tagged Yeast His 32-240 aa
Human CHRNA3-2775H Recombinant Human CHRNA3 Protein (32-240 aa), His-tagged Insect Cell His 32-240 aa
Human CHRNA3-3226HF Recombinant Full Length Human CHRNA3 Protein, GST-tagged In Vitro Cell Free System GST 489 amino acids
Rattus norvegicus (Rat) RFL14526RF Recombinant Full Length Rat Neuronal Acetylcholine Receptor Subunit Alpha-3(Chrna3) Protein, Tag-Free E.coli expression system Tag-Free Full Length of Mature Protein (26-499)
Chicken CHRNA3-5986C Recombinant Chicken CHRNA3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHRNA3 Related Articles
  • CHRNA3 Related Research Area

CHRNA3 involved in several pathways and played different roles in them. We selected most pathways CHRNA3 participated on our site, such as Acetylcholine Binding And Downstream Events, Activation of Nicotinic Acetylcholine Receptors, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acetylcholine Binding And Downstream EventsCHRNA3;CHRNA2;CHRNB4;CHRNB2;CHRNA4;CHRNA1;CHRND;CHRNE;CHRNA5
Activation of Nicotinic Acetylcholine ReceptorsCHRNA2;CHRNB4;CHRNA3;CHRNA7;CHRNE;CHRNA1;CHRNB2;CHRNA5;CHRND
Cholinergic synapseCHRNA4;SLC5A7;CHRM1;JAK2;PIK3CB;CHRM3;KCNQ4;GNGT2;CAMK2D
Highly calcium permeable nicotinic acetylcholine receptorsCHRNA4;CHRNB4;CHRNA5;CHRNB2;CHRNA1;CHRNA2;CHRNA3
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsCHRNA2;CHRNA3;CHRNA5;CHRNA4;CHRNB4;CHRNA7;CHRNB2;CHRNA1
Highly sodium permeable acetylcholine nicotinic receptorsCHRND;CHRNA4;CHRNB2;CHRNA3;CHRNB4;CHRNE
Neuroactive ligand-receptor interactionCRHR2;UTS2R;NPBWR1;CHRNA4;GRIA4A;SCTR;TAAR15;GRIK2;GRM8
Neuronal SystemKCNF1;KCNK13A;LIN7C;KCNF1A;KCNS3A;SLC1A3A;SYN1;KCNN1B;MYO6

CHRNA3 has several biochemical functions, for example, contributes_to acetylcholine binding, acetylcholine binding, acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA3 itself. We selected most functions CHRNA3 had, and list some proteins which have the same functions with CHRNA3. You can find most of the proteins on our site.

Function Related Protein
contributes_to acetylcholine bindingCHRNA10A;CHRNA3;CHRND;CHRNA4B;CHRNB1L;CHRNA4;ZACN;CHRNA10;CHRNE
acetylcholine bindingACHE;CHRNA3;CHRNA4;CHRNA7;CHRM3;CHRNB2;CHRFAM7A;CHRNB3;CHRNB1
acetylcholine receptor activityCHRNA2;CHRNA5;CHRNE;ANXA9;CHRNA3;CHRNB2;CHRNB4;CHRNA7;CHRNA6
acetylcholine-activated cation-selective channel activityCHRNB2;CHRNB3B;CHRNB4;CHRNA1;CHRND;CHRNA2;CHRNB1L;CHRNB3A;CHRNA4
drug bindingSRP54B;DRD4;SMO;DRD1;SRP54A;RARB;HTR2A;CYP2D6;GPR30
ligand-gated ion channel activityCHRNA3;CHRNB2;TRPA1A;CHRNB1;P2RX2;CLCA2;CNGA3;TRPA1B;CLCA5
protein heterodimerization activityTLR1;HMG20B;PKNOX1;DRD1;BCL2L2;TGFB1;HOMER1;DVL3;CLCF1

CHRNA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA3.

CHRNB2; CHRNA5

Gelernter, J; Kranzler, HR; et al. Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans. BIOLOGICAL PSYCHIATRY 77:493-503(2015).
Sieminska, A; Jassem, E; et al. Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. BMC PUBLIC HEALTH 15:-(2015).
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