Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

CHRNA5

  • Official Full Name

    cholinergic receptor, nicotinic, alpha 5

  • Overview

    The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
  • Synonyms

    CHRNA5; LNCR2; cholinergic receptor, nicotinic, alpha 5; neuronal acetylcholine receptor subunit alpha-5; OTTHUMP00000185019; neuronal nicotinic acetylcholine receptor, alpha5 subunit; Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Pan troglodytes (Chimpanzee)
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHRNA5-637H Recombinant Human CHRNA5 Protein, His-tagged HEK293 His
Human CHRNA5-30389TH Recombinant Human CHRNA5 Wheat Germ N/A 94 amino acids
Human CHRNA5-11213H Recombinant Human CHRNA5, GST-tagged E.coli GST 30-250a.a.
Human CHRNA5-1282H Recombinant Human CHRNA5 Protein, GST-Tagged Wheat Germ GST
Mouse CHRNA5-3434M Recombinant Mouse CHRNA5 Protein Mammalian Cell His
Mouse CHRNA5-1665M Recombinant Mouse CHRNA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CHRNA5-1665M-B Recombinant Mouse CHRNA5 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL4830BF Recombinant Full Length Bovine Neuronal Acetylcholine Receptor Subunit Alpha-5(Chrna5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-475)
Gallus gallus (Chicken) RFL18564GF Recombinant Full Length Chicken Neuronal Acetylcholine Receptor Subunit Alpha-5(Chrna5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-454)
Homo sapiens (Human) RFL12761HF Recombinant Full Length Human Neuronal Acetylcholine Receptor Subunit Alpha-5(Chrna5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-468)
Pan troglodytes (Chimpanzee) RFL21348PF Recombinant Full Length Pan Troglodytes Neuronal Acetylcholine Receptor Subunit Alpha-5(Chrna5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-468)
Rattus norvegicus (Rat) RFL26147RF Recombinant Full Length Rat Neuronal Acetylcholine Receptor Subunit Alpha-5(Chrna5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-452)
Zebrafish CHRNA5-2606Z Recombinant Zebrafish CHRNA5 Mammalian Cell His
Chicken CHRNA5-5985C Recombinant Chicken CHRNA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHRNA5 Related Articles
  • CHRNA5 Related Research Area

CHRNA5 involved in several pathways and played different roles in them. We selected most pathways CHRNA5 participated on our site, such as Acetylcholine Binding And Downstream Events, Activation of Nicotinic Acetylcholine Receptors, Highly calcium permeable nicotinic acetylcholine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acetylcholine Binding And Downstream EventsCHRND;CHRNB4;CHRNA3;CHRNA1;CHRNA2;CHRNA5;CHRNE;CHRNB2;CHRNA7
Activation of Nicotinic Acetylcholine ReceptorsCHRNA1;CHRNA3;CHRNA4;CHRNE;CHRNB4;CHRNA5;CHRNA7;CHRND;CHRNA2
Highly calcium permeable nicotinic acetylcholine receptorsCHRNA5;CHRNB2;CHRNA1;CHRNB4;CHRNA3;CHRNA4;CHRNA2
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsCHRNA4;CHRNA1;CHRNA5;CHRNA7;CHRNA2;CHRNB4;CHRNB2;CHRNA3
Neuroactive ligand-receptor interactionPTGIR;MTNR1AA;HCRTR2;GALR1;NPY4R;F2R;GRIK4;GRM5;HTR2A
Neuronal SystemKCNAB2;CCDC167;DLG3;KCNH1B;KCNC1B;KCNJ1A.6;KCNG4A;MYO6;KCNK1A
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellCHRND;DLG1L;HAND2;NSFA;NSFB;PICK1;MYO6;CHRNA2;NCALDA
Nicotine Activity on Dopaminergic Neurons

CHRNA5 has several biochemical functions, for example, contributes_to acetylcholine binding, acetylcholine receptor activity, acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA5 itself. We selected most functions CHRNA5 had, and list some proteins which have the same functions with CHRNA5. You can find most of the proteins on our site.

Function Related Protein
contributes_to acetylcholine bindingCHRNA4B;CHRNA2;CHRNA6;CHRNA2A;CHRNA3;CHRNB3B;CHRNA9;CHRNB1L;CHRND
acetylcholine receptor activityCHRNA2;CHRNA4;CHRNA3;CHRNA7;ANXA9;CHRNB2;CHRNA6;CHRNE;CHRNB4
acetylcholine-activated cation-selective channel activityChrng;CHRNE;CHRND;CHRNB3;CHRNB2;CHRNB3A;CHRNB3B;CHRNA2;CHRNB4
ligand-gated ion channel activityTRPA1A;CHRNA4;CLCA2;Chrng;CHRNB1;CHRNA5;CHRNA3;GABRB1;CLCA5
protein bindingZC4H2;RPSA;NFE2L1;SLC41A3;TMEM194;NUP107;CCL28;DUSP2;RBMY1F
protein heterodimerization activityTENM3;HOMER1;H2BFWT;CA;UGT1A3;DDX1;DRD2;H2AFJ;SMC2

CHRNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA5.

CHRNB2; SRPK2; CHRNA3

Schneider, KK; Hulsse, L; et al. Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed. NEUROREPORT 26:186-191(2015).
Gelernter, J; Kranzler, HR; et al. Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans. BIOLOGICAL PSYCHIATRY 77:493-503(2015).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All CHRNA5 Products

Required fields are marked with *

My Review for All CHRNA5 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends