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CISH

  • Official Full Name

    cytokine inducible SH2-containing protein

  • Overview

    The suppressor of cytokine signaling (SOCS) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway (1-3). The SOCS family consists of at least 8 members including the originally identified cytokine-inducib
  • Synonyms

    CISH; cytokine inducible SH2-containing protein; cytokine-inducible SH2-containing protein; CIS; CIS 1; G18; SOCS; suppressor of cytokine signaling; cytokine-inducible inhibitor of signaling type 1B; CIS-1; BACTS2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CISH-840H Recombinant Human CISH Protein, GST-His-tagged E.coli GST/His
Human CISH-11255H Recombinant Human CISH, GST-tagged E.coli GST 1-258a.a.
Human CISH-1380H Recombinant Human CISH Protein, GST-tagged Wheat Germ GST
Human CISH-7488HCL Recombinant Human CISH 293 Cell Lysate HEK293 N/A
Human CISH-1856HF Recombinant Full Length Human CISH Protein, GST-tagged In Vitro Cell Free System GST 258 amino acids
Human CISH-612H Recombinant Human CISH Protein, His-tagged E.coli His Met1~Leu258
Human CISH-1733H Recombinant Human CISH Protein (Met1-Leu258), His tagged E.coli His Met1-Leu258
Mouse CISH-3484M Recombinant Mouse CISH Protein Mammalian Cell His
Mouse CISH-1700M-B Recombinant Mouse CISH Protein Pre-coupled Magnetic Beads HEK293
Mouse Cish-613M Recombinant Mouse Cish Protein, His-tagged E.coli His Glu79~Gln256
Mouse CISH-1700M Recombinant Mouse CISH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CISH-882R Recombinant Rhesus monkey CISH Protein, His-tagged Mammalian Cell His
Rhesus Macaque CISH-708R-B Recombinant Rhesus Macaque CISH Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CISH-708R Recombinant Rhesus Macaque CISH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CISH-4510Z Recombinant Zebrafish CISH Mammalian Cell His
Chicken CISH-6194C Recombinant Chicken CISH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CISH Related Articles

CISH involved in several pathways and played different roles in them. We selected most pathways CISH participated on our site, such as Cytokine Signaling in Immune system, EPO Receptor Signaling, Growth hormone receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CISH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine Signaling in Immune systemNUP35;LAMTOR2;NOD1;IFIT11;IFI6;EDARADD;IFIT14;SPTA1;IFI27
EPO Receptor SignalingCISH;PTPRUB;PTPRU
Growth hormone receptor signalingGHRB;CSH1;PRLRB;CSHL1;CISH
IL-2 Signaling pathwayITM2BA;CISH;SHB;CD53;NMI
IL-3 Signaling PathwayCISH;GATA1;KCNIP3B;BMX;GATA2;BIRC5A;GATA1A;PILRB;GNB2L1
IL2-mediated signaling eventsDOK2;STAM2;IKZF3;CISH
Immune SystemDEFB119;SIGIRR;ASB17;CD300E;ASB3;DEFA1;TRIM62;S100B;CFHL4
Jak-STAT signaling pathwayPTPN2B;IL22RA2;SOS1;IL6R;HRAS;TYK2;SOCS5B;PIK3CD;FHL1A

CISH has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CISH itself. We selected most functions CISH had, and list some proteins which have the same functions with CISH. You can find most of the proteins on our site.

Function Related Protein
molecular_functionActl10;CTXN3;MSMB;TP53TG5;PLEKHG3;OLFM3A;TMEM14A;MEOX1;NLRP9C
protein bindingBBS7;USP36;SDC4;NPM2;RPS14;AP2B1;C1S;ZNF180;DMPK

CISH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CISH here. Most of them are supplied by our site. Hope this information will be useful for your research of CISH.

EGFR; ERBB2; HSPA6; EPOR; ETV5; MAP3K7CL; SMAD2; Epor; DYNLL1

Esteves, LM; Bulhoes, SM; et al. Human Leptospirosis: Seroreactivity and Genetic Susceptibility in the Population of Sao Miguel Island (Azores, Portugal). PLOS ONE 9:-(2014).
Yan, B; Kuick, CH; et al. Platform Comparison for Evaluation of ALK Protein Immunohistochemical Expression, Genomic Copy Number and Hotspot Mutation Status in Neuroblastomas. PLOS ONE 9:-(2014).
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