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CLASP1

Official Full Name

CLIP associating protein 1
Overview

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM;179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle;(Maiato et al., 2003 (PubMed 12837247)).
Synonyms

CLASP1; CLIP associating protein 1; CLIP-associating protein 1; 1700030C23Rik; B130045P17Rik; FLJ33821; FLJ41222; KIAA0622; MGC131895; mKIAA0622; 5730583A19Rik; CLAP1_HUMAN; CLIP associating protein CLASP1; Cytoplasmic linker associated protein 1; Cytoplasmic linker-associated protein 1; DKFZp686D1968; DKFZp686H2039; hOrbit1; MAST1; Multiple asters 1; Multiple asters homolog 1; Protein Orbit homolog 1; CLASP1alpha; CLIP-associating protein CLASP1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CLASP1-1406H	Recombinant Human CLASP1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CLASP1-188HCL	Recombinant Human CLASP1 lysate	HEK293	N/A		Inquiry
Human	CLASP1-088H	Recombinant Human CLASP1 protein, His-tagged	E. coli	His	1-238 aa	$319 / 25ug

Involved Pathway
Protein Function
Interacting Protein

CLASP1 involved in several pathways and played different roles in them. We selected most pathways CLASP1 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Anchoring of the basal body to the plasma membrane	CEP152;HAUS2;AKAP9;CEP290;TMEM67;NPHP1;TMEM216;CEP63;DCTN3
Assembly of the primary cilium	KIF3CB;CNGA2;KIF3A;EXOC3;TTC21B;CEP78;CEP63;TTC8;CSNK1E
Axon guidance	FYN;SEMA7A;LIMK1;SPRED2;FGF8B;ITGB1B.1;RASA1;NEFLB;ARPC1B
Cell Cycle	CDKN2A;BANF1;RBL2;DKC1;SYCP2;SDCCAG8;CSNK2A1;AHCTF1;BRCC3
Cell Cycle, Mitotic	LMNB1;CDK5RAP2;SETB;NUPL2;SKA2;AHCTF1;SGOL1;NEK7;CDCA8
Centrosome maturation	DCTN3;MAPRE1A;TUBGCP5;DCTN1A;CDK11A;CSNK1D;ODF2B;CLASP1;TUBB4B
Developmental Biology	CLASP1;SCN4A;CSNK2A2;KIF4;EZRA;CACNG3;COL6A2;MED20;EFNB2
G2/M Transition	CEP164;DCTN2;DCTN3;LIN52;TUBG2;CENPJ;CEP72;ODF2B;PCM1

CLASP1 has several biochemical functions, for example, dystroglycan binding, kinetochore binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLASP1 itself. We selected most functions CLASP1 had, and list some proteins which have the same functions with CLASP1. You can find most of the proteins on our site.

Function	Related Protein
dystroglycan binding	DAG1;AGR3;AGRN;MAP2;AGR2;VCL;GYLTL1B;DMD;CLASP1
kinetochore binding	CENPH;CCDC99;CLASP1;SPDL1;CLASP1A
microtubule binding	RGS14;MAPRE1A;MARK4;KIF22;KIF3C;TRAF3IP1;MTAP1B;MAP1LC3B;KRIT1
microtubule plus-end binding	KIF18A;APC;CLIP2;STIM1;CLIP1;CLASP1;MAPRE1;CLASP1A;DST
protein binding	NFYC;TDP2;FGB;RBCK1;HDAC7A;CASP2;CALM2;CFLAR;GLIS2

CLASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLASP1.

YWHAG; KIF1B; SPAG5; Clip2; Clip1; Cenpe; PHLDB2; HTT; pyrB; Soga1; Cenpe