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CLCA2

  • Official Full Name

    chloride channel accessory 2

  • Overview

    The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.
  • Synonyms

    CLCA2; chloride channel accessory 2; chloride channel regulator 2 , chloride channel, calcium activated, family member 2; calcium-activated chloride channel regulator 2; CLCRG2; 35 kDa form; CaCC-3; CaCC3; Calcium-activated chloride channel family member 2; Calcium-activated chloride channel protein 3; Calcium-activated chloride channel-2; Chloride channel, calcium activated, family member 2; CLCA2_HUMAN; hCaCC-3; hCLCA2; OTTHUMP00000011911; chloride channel regulator 2; CLCA family member 2, chloride channel regulator; calcium-activa; CACC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLCA2-11274H Recombinant Human CLCA2, GST-tagged E.coli GST 595-901a.a.
Human CLCA2-168H Recombinant Human CLCA2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CLCA2-1409H Recombinant Human CLCA2 Protein, GST-tagged Wheat Germ GST
Human CLCA2-7478HCL Recombinant Human CLCA2 293 Cell Lysate HEK293 N/A
Human CLCA2-8091HFL Recombinant Full Length Human CLCA2 protein, Flag-tagged Mamanlian cells Flag
Human CLCA2-1123H Recombinant Human CLCA2 Protein, His-tagged E.coli His 595-901 aa
Mouse Clca2-2176M Recombinant Mouse Clca2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLCA2 Related Articles
  • CLCA2 Related Research Area

CLCA2 involved in several pathways and played different roles in them. We selected most pathways CLCA2 participated on our site, such as Renin secretion, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Renin secretionPRKACG;GNAQ;ITPR1;CLCA4;GNAS;ITPR3;AQP1;PDE1B;CLCA3
Pancreatic secretionCPA3;SLC9A1;PRKCG;TRPC1;ATP1A3;SLC4A4;TPCN2;Slc4a2;PNLIPRP1

CLCA2 has several biochemical functions, for example, chloride channel activity, intracellular calcium activated chloride channel activity, ligand-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCA2 itself. We selected most functions CLCA2 had, and list some proteins which have the same functions with CLCA2. You can find most of the proteins on our site.

Function Related Protein
chloride channel activityANO2;GABRA1;CLCA1;TTYH2L;BEST1;CLIC1;SLC26A7;CLCA3;GABRE
intracellular calcium activated chloride channel activityANO2;NMUR2;CLCA2;CLCA1;CLCA4;ANO6;ANO9;ANO4;ANO8
ligand-gated ion channel activityCHRNB2;P2RX2;CHRNB4;TRPA1A;CLCA5;CHRNA3;CHRNB1;CLCA2;GABRB1
metal ion bindingZFP523;ESRRGA;KLF15;KAT5;FGD5;RCVRNA;TGFBR2;RHOT1A;VAV3
metallopeptidase activityMMP1A;DPP3;ADAM10B;STAMBPL1;PAPPA2;HE2;ADAM1B;ADAMTSL1;ADAM15

CLCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCA2.

ALB

Gonzalez-Silva, C; Vera, J; et al. Ca2+-Activated Cl- Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons. PLOS ONE 8:-(2013).
Kim, KX; Marcus, DC; et al. Inward-rectifier chloride currents in Reissner's membrane epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394:434-438(2010).
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