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CLOCK

  • Official Full Name

    circadian locomotor output cycles kaput

  • Overview

    Circadian rhythms govern many key physiological processes that fluctuate with a period of approximately 24 hours. These processes include the sleep-wake cycle, glucose, lipid and drug metabolism, heart rate, hormone secretion, renal blood flow, and body t
  • Synonyms

    CLOCK; circadian locomotor output cycles kaput; circadian locomoter output cycles protein kaput; mCLOCK; circadian locomoter output cycles kaput; KAT13D; bHLHe8; mKIAA0334; 5330400M04Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLOCK-11340H Recombinant Human CLOCK, GST-tagged E.coli GST 1-351a.a.
Human CLOCK-75H Recombinant Human CLOCK, GST-tagged Wheat Germ GST
Human CLOCK-7436HCL Recombinant Human CLOCK 293 Cell Lysate HEK293 N/A
Human CLOCK-1526H Recombinant Human CLOCK protein, His & T7-tagged E.coli His/T7 Ala34~Ala379 (Accession # O15516)
Human CLOCK-6888HF Recombinant Full Length Human CLOCK Protein, GST-tagged In Vitro Cell Free System GST 846 amino acids
Mouse CLOCK-3596M Recombinant Mouse CLOCK Protein Mammalian Cell His
Mouse CLOCK-1765M Recombinant Mouse CLOCK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CLOCK-1765M-B Recombinant Mouse CLOCK Protein Pre-coupled Magnetic Beads HEK293
Rat CLOCK-1459R Recombinant Rat CLOCK Protein Mammalian Cell His
Rat CLOCK-1117R Recombinant Rat CLOCK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CLOCK-1117R-B Recombinant Rat CLOCK Protein Pre-coupled Magnetic Beads HEK293
Chicken CLOCK-5488C Recombinant Chicken CLOCK Mammalian Cell His
Chicken CLOCK-5748C Recombinant Chicken CLOCK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLOCK Related Articles
  • CLOCK Related Research Area

CLOCK involved in several pathways and played different roles in them. We selected most pathways CLOCK participated on our site, such as Circadian rhythm, Dopaminergic synapse, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLOCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Circadian rhythmCRY1;NPAS2;RBX1;PER3;ARNTL;PRKAB2;PRKAG3;RORB;PRKAG2
Dopaminergic synapseCREB3;PPP2R5C;GNB1;CALM3;PPP1CA;KIF5C;GNG5;GNG13;KIF5B
Herpes simplex infectionIFNAR2;Ccl12;FB06F03;CUL1A;TTC6;MED8;MAVS;IFNA1;MHC1UEA

CLOCK has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLOCK itself. We selected most functions CLOCK had, and list some proteins which have the same functions with CLOCK. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHLFA;DLX4A;BBX;ILF3;ZNF683;TAF12;SALL1;BANF1;HOXA10B
E-box bindingARNTL2;CLOCK;MYOG;C1orf51;NEUROG1;TCF21;SREBF2;ZEB1;TAL1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingTCF7L2;MESP1;E2F4;ZNF486;PATZ1;TBP;ZNF502;CTCFL;RFX6
chromatin DNA bindingHIST1H1E;PER1;VAX1;ATOH1;APEX1;SLAMF7;PRDM14;FOXC2;HIST1H1D
core promoter bindingNKX3-1;GADD45A;HDAC4;AGO1;NKX2-1;EP300;E2F3;KLF4;SFPI1
histone acetyltransferase activityTAF1;NCOA1;KAT6A;KAT5;CREBBP;KAT7B;KAT7;CDYL;METTL8
protein bindingTCEB2;LGALS2;TCF3;LRRC47;MAST2;CDKN1C;ACTN3;PRKCA;PVRL2
protein dimerization activityCELSR1;NPAS1;EBF1;TCF3A;MXI1;FBXW11;PEX3;OLIG4;TWIST2
sequence-specific DNA bindingSOX21A;RREB1;FOXO1;HOXB8A;TLX3B;HLFB;MYOG;HLX;HOXB3A
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingCLOCK;ARNTL;DDN;ATF3;IRF7;JDP2;BATF;MSX1;RBPJA
transcription factor activity, sequence-specific DNA bindingRFX5;ZFP516;ETS2;ZFP35;HSF2;PAX8;POU4F2;KDM5B;ZNF334
transcriptional activator activity, RNA polymerase II transcription factor bindingMIXL1;NFE2L1;SOX10;GBX2;MED12;NKX2-5;CLOCK;NOTCH1;KLF14

CLOCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLOCK here. Most of them are supplied by our site. Hope this information will be useful for your research of CLOCK.

ARNTL; bamB; ARNTL2; mdm2_human_probe; Cry1

Lau, SKP; Woo, PCY; et al. Discovery of a Novel Coronavirus, China Rattus Coronavirus HKU24, from Norway Rats Supports the Murine Origin of Betacoronavirus 1 and Has Implications for the Ancestor of Betacoronavirus Lineage A. JOURNAL OF VIROLOGY 89:3076-3092(2015).
Sheng, WL; Chen, WY; et al. Co-Expression of Two Subtypes of Melatonin Receptor on Rat M1-Type Intrinsically Photosensitive Retinal Ganglion Cells. PLOS ONE 10:-(2015).
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