CLSPN
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Official Full Name
claspin
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Overview
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] -
Synonyms
CLSPN; claspin; hClaspin; claspin homolog;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Mouse | CLSPN-3607M | Recombinant Mouse CLSPN Protein | Mammalian Cell | His |
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| Mouse | CLSPN-1770M-B | Recombinant Mouse CLSPN Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | CLSPN-1770M | Recombinant Mouse CLSPN Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Chicken | CLSPN-4247C | Recombinant Chicken CLSPN | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
CLSPN involved in several pathways and played different roles in them. We selected most pathways CLSPN participated on our site, such as Activation of ATR in response to replication stress, Apoptosis, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLSPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of ATR in response to replication stress | RAD9;CHEK1;RAD17;CLSPN;MCM10;RAD1;RAD9B;CDK2;RAD9A |
| Apoptosis | HMGB2A;CDK5RAP2;Gzmg;NFKBIA;PRKACA;BNIP3L;ATM;DSP;PIK3R5 |
| Apoptotic cleavage of cellular proteins | DBNLA;CASP6L1;CASP8L1;BMX;SATB1;PKP1;BCAP31;SPNA2;DBNL |
| Apoptotic execution phase | STK24B;GAS2;CTNNB2;CTNNB1;DBNLB;STK24A;DSP;HIST1H1E;DSG1 |
| Cell Cycle | CEP135;ITGB3BP;DMC1;UIMC1;PRKDC;GOLGA2;SKP1;POT1;GADD45A |
| Cell Cycle Checkpoints | RNF168;HIST4H4;CDK5RAP2;RAD1;HUS1;TP53BP1;RAD9B;UIMC1;HIST3H2BB |
| DNA Double-Strand Break Repair | TDP2;KDM4B;PPP4R2;RAD51AP1;PAXIP1;RIF1;GEN1;EME1;PARP2 |
| DNA Repair | FAM175A;PIAS3;INO80C;ZBTB32;COPS7A;UBE2L6;TIMELESS;COPS4;USP10 |
CLSPN has several biochemical functions, for example, DNA binding, DNA secondary structure binding, anaphase-promoting complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLSPN itself. We selected most functions CLSPN had, and list some proteins which have the same functions with CLSPN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | POLR2J2;TGIF2LX;NUPR1;NFYA;NR4A3;SOX1;IRF1B;GTF2A1L;NKX2.2A |
| DNA secondary structure binding | |
| anaphase-promoting complex binding | PLK1;CLSPN;PTEN |
CLSPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLSPN here. Most of them are supplied by our site. Hope this information will be useful for your research of CLSPN.
MCM3; INPP5B; MCM4; MCM5; MCM7; MCM2; MCM6; PNKD; RAPGEF6; RNF170; TMEM246; GINS4; MMTAG2; TIPIN; KIF26A; TIMELESS
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