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CNOT4

Official Full Name

CCR4-NOT transcription complex, subunit 4
Overview

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms

CNOT4; CCR4-NOT transcription complex, subunit 4; NOT4; CCR4-NOT transcription complex subunit 4; CLONE243; NOT4H; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; potential transcriptional repressor NOT4Hp; NOT4 (negative regulator of transcr;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CNOT4-1582H	Recombinant Human CNOT4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CNOT4-7400HCL	Recombinant Human CNOT4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CNOT4-7401HCL	Recombinant Human CNOT4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CNOT4-1938HF	Recombinant Full Length Human CNOT4 Protein, GST-tagged	In Vitro Cell Free System	GST	565 amino acids	Inquiry
Mouse	Cnot4-2221M	Recombinant Mouse Cnot4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Chicken	CNOT4-2039C	Recombinant Chicken CNOT4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CNOT4 Related Articles

CNOT4 involved in several pathways and played different roles in them. We selected most pathways CNOT4 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RNA degradation	EDC3;PAN2;HSPA9;EXOSC2;CNOT1;C1D;SMX5;EXOSC5;EXOSC8

CNOT4 has several biochemical functions, for example, ligase activity, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT4 itself. We selected most functions CNOT4 had, and list some proteins which have the same functions with CNOT4. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	DTX3;HECTD1;UNKL;RNF185;TRAIP;RNF212;RNF19A;RNF220;TRIM23
nucleotide binding	NLRP4E;RBM23;CDK14;MYO5A;ABCG4B;DHX34;GNAI2A;ARL4AB;HNRNPM
poly(A) RNA binding	CPEB4;UBAP2;TXN;RPS27L;EIF3I;RRP9;STAU2;THOC4;SF3B14
protein binding	TRAM1;PRKCI;SLC30A8;TNK1;STX4;NCKIPSD;ATF6;ARHGEF16;FAM212A
ubiquitin-protein transferase activity	KLHL20;SMURF2;ZYG11B;PDZRN3B;UBE2G1;RAG1;TRIM2;CBLB;UBE2K
zinc ion binding	CHURC1;ZDHHC5A;DTX4;UPF1;ADH1A;ADAMTS18;SLU7;ADH8A;MUL1

CNOT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT4.

UBE2D3; UBE2N; UBE2D2; EP300; UBE2E3; UBE2W; UBE2D4; MYC

Babbarwal, V; Fu, JH; et al. The Rpb4/7 Module of RNA Polymerase II Is Required for Carbon Catabolite Repressor Protein 4-Negative on TATA (Ccr4-Not) Complex to Promote Elongation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:33125-33130(2014).

Venturini, G; Rose, AM; et al. CNOT3 Is a Modifier of PRPF31 Mutations in Retinitis Pigmentosa with Incomplete Penetrance. PLOS GENETICS 8:-(2012).