cnot4
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  • Official Full Name
  • CCR4-NOT transcription complex, subunit 4
  • Background
  • The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CNOT4; CCR4-NOT transcription complex, subunit 4; NOT4; CCR4-NOT transcription complex subunit 4; CLONE243; NOT4H; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; potential transcriptional repressor NOT4Hp; NOT4 (negative regulator of transcr
Cat.#:CNOT4-1582HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CNOT4 Protein, GST-tagged
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Cat.#:CNOT4-2039CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CNOT4
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Cat.#:CNOT4-7400HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CNOT4 293 Cell Lysate
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Cat.#:CNOT4-7401HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CNOT4 293 Cell Lysate
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Involved Pathway

CNOT4 involved in several pathways and played different roles in them. We selected most pathways CNOT4 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA degradation
CNOT3B; CNOT3A; CNOT4B; BTG2; PFKMB; ZCCHC7; ENO3; groL; PABPC1; WDR61

Protein Function

CNOT4 has several biochemical functions, for example, ligase activity, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT4 itself. We selected most functions CNOT4 had, and list some proteins which have the same functions with CNOT4. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein LIG4; TRIM32; TRAIP; RBX1; SMURF1; RLIM; UBE2F; HERC2; RNF20; NEDD4
Function nucleotide binding
Related Protein HRASA; RALBB; RBM12; RBM18; RAB5AA; RBM39A; ACTA1B; GKUP; MXA; ABCB4
Function poly(A) RNA binding
Related Protein SRSF10; SRSF4; TARDBP; DDX28; RPS4Y2; PELP1; MAPRE1; EIF4ENIF1; C14orf21; FAM103A1
Function protein binding
Related Protein CAML; ZFP110; KIAA1274; CEACAM21; CA2; PPIF; TNF; POLRMT; FAM120B; CDC5L
Function ubiquitin-protein transferase activity
Related Protein DTX3L; RNF135; CBLL1; UBE2D2A; UBE2S; UBE2D4; SMURF2; MARCH5; TRIM69; RCHY1
Function zinc ion binding
Related Protein KLF7; LMO1; FHL2; MEP1A.2; KAT7A; DBF4B; NR2F1; NR2F6; ZMAT4; FBXO11

Interacting Protein

CNOT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT4.
UBE2D3; UBE2N; UBE2D2; EP300; UBE2E3; UBE2W; UBE2D4; MYC

CNOT4 Related Articles

Babbarwal, V; Fu, JH; et al. The Rpb4/7 Module of RNA Polymerase II Is Required for Carbon Catabolite Repressor Protein 4-Negative on TATA (Ccr4-Not) Complex to Promote Elongation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:33125-33130(2014).
Venturini, G; Rose, AM; et al. CNOT3 Is a Modifier of PRPF31 Mutations in Retinitis Pigmentosa with Incomplete Penetrance. PLOS GENETICS 8:-(2012).