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COBRA1

Official Full Name

cofactor of BRCA1
Overview

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or;NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a;heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA;polymerase II (see MIM 180660) (Narita et al., 2003 (PubMed 12612062)).
Synonyms

COBRA1; cofactor of BRCA1; negative elongation factor B; KIAA1182; NELF B; A730008L03Rik; AB041607; DKFZp586B0519; AI663983; Negative elongation factor protein B; NELFB; RGD1307832; RP13-122B23.3; RP23-132N23.4; NELF-B;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COBRA1-1618H	Recombinant Human COBRA1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COBRA1-377HCL	Recombinant Human COBRA1 cell lysate		N/A		Inquiry
Human	COBRA1-2006HF	Recombinant Full Length Human COBRA1 Protein, GST-tagged	In Vitro Cell Free System	GST	475 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein

COBRA1 involved in several pathways and played different roles in them. We selected most pathways COBRA1 participated on our site, such as Abortive elongation of HIV-1 transcript in the absence of Tat, Disease, Formation of HIV elongation complex in the absence of HIV Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with COBRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Abortive elongation of HIV-1 transcript in the absence of Tat	TH1L;SUPT4H1;SUPT5H;RDBP;WHSC2;CTDP1;COBRA1
Disease	GPC6;AP2A1;GCKR;AMN;AP2M1;SFTPC;MMAA;NPM1;CPSF4
Formation of HIV elongation complex in the absence of HIV Tat	TH1L;RDBP;CTDP1;SUPT4H1;WHSC2;CDK9;SSRP1;ELL;TCEA1
Formation of HIV-1 elongation complex containing HIV-1 Tat	SUPT4H1;SUPT5H;CTDP1;RDBP;TCEB3;TH1L;WHSC2;TCEA1;CDK9
Formation of RNA Pol II elongation complex	TCEA1;WHSC2;CCNT2A;TCEB3;PSTPIP2;SSRP1A;SSRP1;SUPT16H;ELL
Formation of the Early Elongation Complex	SUPT5H;TH1L;NELFE;GM3258;COBRA1;WHSC2;SUPT4H1;CTDP1;RDBP
Formation of the HIV-1 Early Elongation Complex	RDBP;SUPT5H;CTDP1;SUPT4H1;WHSC2;COBRA1;TH1L
Gene Expression	ZNF12;POP4;MTERF;SKILB;KIAA1456;ZNF354B;DDX6;C2orf49;ZNF496

COBRA1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COBRA1 itself. We selected most functions COBRA1 had, and list some proteins which have the same functions with COBRA1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	CBX4;CDHR1;FXYD6;SYCE2;PLD1;XRCC3;ERCC5;ZNF212;PIM1

COBRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COBRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COBRA1.

NELFE; BRCA1; NELFA; DENR; KHDRBS3; MGST1; HSPA9