col3a1
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  • Official Full Name
  • collagen, type III, alpha 1
  • Background
  • This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
  • Synonyms
  • COL3A1; collagen, type III, alpha 1; EDS4A; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant;
Cat.#:COL3A1-1650HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL3A1 Protein, GST-tagged
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Cat.#:COL3A1-3440HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human COL3A1 Protein, His-tagged
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Cat.#:COL3A1-1957HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Collagen, Type III, Alpha 1
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Cat.#:COL3A1-19587HTag:
Source (Host):Pichia pastorisSpecies:Human
Product nameRecombinant Human COL3A1 protein
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Cat.#:COL3A1-28012THTag:
Source (Host):Species:Human
Product nameRecombinant Human COL3A1
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Cat.#:COL3A1-604HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human COL3A1, His-tagged
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Cat.#:COL3A1-72HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL3A1
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Cat.#:COL3A1-73HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL3A1 protein, MYC/DDK-tagged
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Cat.#:COL3A1-7927HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL3A1 protein, His & GST-tagged
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Cat.#:COL3A1-09MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Col3a1 protein, His-tagged
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Cat.#:COL3A1-3734MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL3A1 Protein
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Cat.#:Col3a1-7928MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Col3a1 protein, His-tagged
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Cat.#:COL3A1-1522RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COL3A1 Protein
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Cat.#:Col3a1-7929RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Col3a1 protein, His-tagged
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Cat.#:COL3A1-961RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COL3A1 Protein, His-tagged
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Cat.#:COL3A1-6932CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COL3A1
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Involved Pathway

COL3A1 involved in several pathways and played different roles in them. We selected most pathways COL3A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL3A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amoebiasis
ACTN1; VCL; LAMB1; FN1; ARG1; IL1R2; PLCB3; ITGB2; LAMB2; COL5A1
Assembly of collagen fibrils and other multimeric structures
CTSB; COL11A1B; COL4A5; COL5A2; PCOLCE; ABHD1; COL5A3A; COL5A1; MMP13; BMP1
Binding and Uptake of Ligands by Scavenger Receptors
LOC479668; HPX; AMBP; STAB2; HSPH1; APOBB.1; COL1A2; COL1A1; IGKC; NFX1
Collagen biosynthesis and modifying enzymes
COL1A2; COL2A1; COL6A1; PCOLCEB; COL9A3; TLDC2; PCOLCE2; COL4A5; COL6A3; COL28A1
Collagen formation
COL4A6; BMP1A; COL9A1; EMID2; COL25A1; COL5A3A; COL15A1B; LOXL2; COL6A2; BMP1
ECM-receptor interaction
ITGA6; COL1A2; COL6A4; THBS1; COL24A1; ITGB8; GP5; ITGA2B; COL4A4; LAMA4
Endothelins
COL1A2; EDNRA; CYSLTR1; EDN3; COL3A1; EDN1; EDN2; EDNRB
Extracellular matrix organization
MMP12; MGC174857; EMID2; CEACAM6; FN1B; PCOLCE; ADAMTS2; COL5A1; MFAP3; COL28A1

Protein Function

COL3A1 has several biochemical functions, for example, SMAD binding, extracellular matrix structural constituent, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL3A1 itself. We selected most functions COL3A1 had, and list some proteins which have the same functions with COL3A1. You can find most of the proteins on our site.
Function
Related Protein
Function SMAD binding
Related Protein SKIA; COL1A2; PML; PURB; SKOR1A; SOD3; TCF12; TGFBR3; AXIN1; FOXH1
Function extracellular matrix structural constituent
Related Protein IMPG1; COL5A3B; COL1A1A; FBLN2; CHI3L1; MATN1; CD4; FBN2B; MFAP5; LAMB1
Function integrin binding
Related Protein TGFBI; ANXA7; ICAM2; MMP14; FERMT3; P4HB; KDR; ADAM10; AMICA1; ADAM15
Function metal ion binding
Related Protein SUCLA2; B3GAT1; INSM2; XRCC6BP1; AOX3; OVCH2; DDHD2; ZNF652; BCL6A; ROCK2B
Function platelet-derived growth factor binding
Related Protein COL1A1; COL6A1; COL5A1; Pdgfa&Pdgfb; PDGFRB; COL2A1; COL3A1; PDGFRA; PDGFB; COL1A2
Function protein binding
Related Protein PSMD9; PNRC2; ABCG2; SSX1; CRH; HMGN4; ADAM17; NR1D1; FBXW7; TNFRSF10B

Interacting Protein

COL3A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL3A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL3A1.
all3_aedae; zwf; LOX; ispH; lcrS; pdpD2; q5nfa1_fratt; galT; pbpG; htrE; nagE; opuD; mutTA; thiF; katB; rpoB; q81vw1_bacan; q8ckb2_yerpe; mutY

COL3A1 Related Articles

Vittal, R; Mickler, EA; et al. Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-beta and Associated Transcripts in Pulmonary Fibrosis. PLOS ONE 8:-(2013).
Hung, CF; Rohani, MG; et al. Role of IGF-1 pathway in lung fibroblast activation. RESPIRATORY RESEARCH 14:-(2013).