COL3A1
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Official Full Name
collagen, type III, alpha 1
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Overview
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008] -
Synonyms
COL3A1; collagen, type III, alpha 1; EDS4A; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant;
- Recombinant Proteins
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Bovine (calf ) skin. Collagen was extracted from washed dissected tissue into dilute acetic acid after pepsin treatment. Collagen type III was purified by using differential salt precipitation.
- Bovine placenta
- E.coli
- HEK293
- HEK293T
- Human Placenta
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- P.pastoris
- Synthetic Peptide
- Wheat Germ
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | COL3A1-604H | Active Recombinant Human COL3A1, His-tagged | Mammalian cells | His |
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| Human | COL3A1-28012TH | Recombinant Human COL3A1 | N/A |
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| Human | COL3A1-1650H | Recombinant Human COL3A1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | COL3A1-72H | Recombinant Human COL3A1 | E.coli | N/A |
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| Human | COL3A1-19587H | Recombinant Human COL3A1 protein | P.pastoris | N/A |
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| Human | COL3A1-1957H | Recombinant Human Collagen, Type III, Alpha 1 | P.pastoris | N/A |
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| Human | COL3A1-73H | Recombinant Human COL3A1 protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | COL3A1-7927H | Recombinant Human COL3A1 protein, His & GST-tagged | E.coli | His/GST | Gly1059~Leu1466 (Accession # P02461) |
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| Human | COL3A1-001H | Native Human COL3A1 Protein | Human Placenta |
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| Human | COL3A1-01H | Recombinant Human COL3A1 protein, His-tagged | HEK293 | His | 1466 aa |
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| Human | COL3A1-3440H | Recombinant Human COL3A1 Protein, His-tagged | Yeast | His |
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| Human | COL3A1-2793H | Recombinant Human COL3A1 Protein, His-tagged | Synthetic Peptide | N-His |
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| Human | COL3A1-301178H | Recombinant Human COL3A1 protein, GST-tagged | E.coli | GST | Gln24-Ser152 |
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| Human | COL3A1-5149H | Recombinant Human COL3A1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | COL3A1-2713H | Recombinant Human COL3A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | COL3A1-2157H | Recombinant Human COL3A1 Protein, His-tagged | E.coli | N-His | Asp1222-Leu1466 |
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| Human | COL3A1-2713H-B | Recombinant Human COL3A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | COL3A1-2794H | Recombinant Human COL3A1 Protein, His-tagged | Synthetic Peptide | N-His |
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| Human | COL3A1-4013H | Recombinant Human COL3A1 Protein (Gln24-Pro153), N-His tagged | E.coli | N-His | Gln24-Pro153 |
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| Human | COL3A1-6634HFL | Recombinant Full Length Human COL3A1 protein, Flag-tagged | Mamanlian cells | Flag |
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| Human | COL3A1-2163HF | Recombinant Full Length Human COL3A1 Protein, GST-tagged | In Vitro Cell Free System | GST | 1163 amino acids |
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| Mouse | COL3A1-09M | Recombinant Mouse Col3a1 protein, His-tagged | HEK293 | His |
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| Mouse | COL3A1-3734M | Recombinant Mouse COL3A1 Protein | Mammalian Cell | His |
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| Mouse | Col3a1-7928M | Recombinant Mouse Col3a1 protein, His-tagged | E.coli | His | Gly434~Pro643 (Accession # P08121) |
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| Mouse | COL3A1-1862M | Recombinant Mouse COL3A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Col3a1-1281M | Recombinant Mouse Col3a1 Protein, His-tagged | E.coli | N-His | Asp1220-Leu1464 |
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| Mouse | Col3a1-5628M | Recombinant Mouse Col3a1 Protein (Gln155-Gly1219), C-His tagged | Mammalian cells | C-His | Gln155-Gly1219 |
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| Mouse | COL3A1-1862M-B | Recombinant Mouse COL3A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Col3a1-1282M | Recombinant Mouse Col3a1 Protein, His&GST-tagged | E.coli | N-His&GST | Gln24-Pro154 |
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| Rat | COL3A1-1522R | Recombinant Rat COL3A1 Protein | Mammalian Cell | His |
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| Rat | Col3a1-7929R | Recombinant Rat Col3a1 protein, His-tagged | E.coli | His | Arg1171~Arg1435 (Accession # P13941) |
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| Rat | COL3A1-1179R | Recombinant Rat COL3A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | Col3a1-1280R | Recombinant Rat Col3a1 Protein, His-tagged | E.coli | N-His | Asp1219-Leu1463 |
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| Rat | COL3A1-1179R-B | Recombinant Rat COL3A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Bovine | COL3A1-17B | Native Bovine COL3A1 Protein | Bovine placenta |
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| Bovine | COL3A1-18B | Native Bovine COL3A1 Protein | Bovine (calf ) skin. Collagen was extracted from washed dissected tissue into dilute acetic acid after pepsin treatment. Collagen type III was purified by using differential salt precipitation. |
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| Rhesus Macaque | COL3A1-961R | Recombinant Rhesus monkey COL3A1 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | COL3A1-786R | Recombinant Rhesus Macaque COL3A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | COL3A1-786R-B | Recombinant Rhesus Macaque COL3A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | COL3A1-6932C | Recombinant Chicken COL3A1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- COL3A1 Related Articles
- COL3A1 Related Research Area
COL3A1 involved in several pathways and played different roles in them. We selected most pathways COL3A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL3A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | ITGB2;IL1B2;LAMA5;SERPINB1B;CD1D;PTK2;HSPB1;IL6;COL2A1 |
| Assembly of collagen fibrils and other multimeric structures | TLL1;COL1A1;COL5A2;COL8A1;COL8A1A;PLEC;COL10A1A;COL6A1;TLL2 |
| Binding and Uptake of Ligands by Scavenger Receptors | APOBB.1;STAB2;COL1A2;APOA1B;AMBP;HSPH1;HYOU1;IGKC;SAA1 |
| Collagen biosynthesis and modifying enzymes | SERPINH1B;COL1A2;LEPREL2;COL9A1;COL17A1A;BMP1A;TLL1;COL4A5;COL1A1 |
| Collagen formation | ABHD1;COL8A1A;COL16A1;COL2A1;BMP1B;TLDC2;CTSL2;COL3A1;COL4A4 |
| ECM-receptor interaction | LAMA4;COL27A1A;TNXB;LAMB1A;ITGA7;Npnt;ITGAV;ITGB4;Itga10&Itgb1 |
| Endothelins | CYSLTR1;EDN3;EDN2;EDNRA;EDN1;EDNRB;COL1A2;COL3A1 |
| Extracellular matrix organization | CRTAP;BGNA;COL16A1;DMP1;LAMB1B;COL5A1;FBLN1;TIMP2B;ADAMTS4 |
COL3A1 has several biochemical functions, for example, SMAD binding, extracellular matrix structural constituent, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL3A1 itself. We selected most functions COL3A1 had, and list some proteins which have the same functions with COL3A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SMAD binding | SMURF2;EP300;EID2;TOB1;SKIB;TGFBR2;SMAD2;SKOR1;COL3A1 |
| extracellular matrix structural constituent | ELNA;COL1A2;TINAGL1;COL4A3;CD4;COL5A2;MGP;MEPE;ELN |
| integrin binding | COL3A1;ECM2;CIB2;GFAP;TLN1;ESM1;ADAM2;VWF;ACTN3 |
| metal ion binding | SMG1;PRDM12;DNAJA3;SEMG2;MMP14B;MMP14A;TRIM35-24;NME4;METAP2A |
| platelet-derived growth factor binding | PDGFRA;PDGFA;PDGFRB;COL2A1;Pdgfa&Pdgfb;PDGFB;COL1A1;COL1A2;COL5A1 |
| protein binding | EIF3E;RNF115;MTMR6;DIAPH1;NEIL2;CPSF6;DIXDC1;MAP3K8;ALDH7A1 |
COL3A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL3A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL3A1.
all3_aedae; zwf; LOX; ispH; lcrS; pdpD2; q5nfa1_fratt; galT; pbpG; htrE; nagE; opuD; mutTA; thiF; katB; rpoB; q81vw1_bacan; q8ckb2_yerpe; mutY
- Q&As
- Reviews
Q&As (5)
Ask a questionUnderstanding the specific genetic and protein alterations in vEDS patients can help tailor individualized treatment strategies based on the patient's unique molecular profile.
Yes, analysis of COL3A1 protein levels in prenatal samples may provide valuable information for assessing the risk of vEDS in the developing fetus.
Elevated or decreased levels of COL3A1 protein may serve as potential biomarkers for early detection and risk assessment of vEDS, especially in at-risk individuals or families.
Challenges include the need for standardized assays and reference ranges for COL3A1 protein levels, as well as the interpretation of results in the context of individual patient variability.
Yes, monitoring changes in COL3A1 protein levels may provide insights into disease progression and response to treatment in vEDS patients.
Customer Reviews (3)
Write a reviewThis protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.
The COL3A1 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.
the COL3A1 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.
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