cops2
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  • Official Full Name
  • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
  • Background
  • Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • Synonyms
  • COPS2; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); COP9 signalosome complex subunit 2; ALIEN; CSN2; TRIP15; Alien homolog; COP 9; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COPS 2; CSN2_HUMAN; JAB1 containing signalosome subunit 2; JAB1-containing signalosome subunit 2; SGN 2; SGN2; Signalosome subunit 2; ThyroidHormone Receptor Interactor15; Thyroid Hormone Receptor Interactor 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP 15; TRIP-15; thyroid receptor interacting protein 15
Cat.#:COPS2-1700HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COPS2 Protein, GST-tagged
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Cat.#:COPS2-24HTag:T7/His/TEV cleavage site
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COPS2 protein, T7/His-tagged
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Cat.#:COPS2-25HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COPS2 protein, GST-tagged
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Cat.#:COPS2-1532RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COPS2 Protein
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Cat.#:COPS2-971RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COPS2 Protein, His-tagged
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Cat.#:COPS2-3236CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COPS2
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Cat.#:COPS2-289ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COPS2
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Cat.#:COPS2-7359HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COPS2 293 Cell Lysate
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Involved Pathway

COPS2 involved in several pathways and played different roles in them. We selected most pathways COPS2 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
YY1; COPS6; COPS3; CETN2; INO80E; INO80B; COPS8; GPS1; COPS7B; ACTL6A
DNA Repair
ASCC1; GPS1; DCLRE1A; KDM4A; RTEL1; INO80E; FUZ; COPS8; RAD1; EME1
Formation of TC-NER Pre-Incision Complex
DDB1; KIAA1530; TCEA1; ZFP830; COPS7B; COPS7A; COPS2; COPS4; COPS3; ZNF830
Global Genome Nucleotide Excision Repair (GG-NER)
ACTL6A; COPS8; COPS7B; PARP2; CHD1L; INO80B; NFRKB; MCRS1; ACTR5; USP45
Nucleotide Excision Repair
POLE4; RPA3; RAD23AA; COPS6; GTF2H3; RFC1; INO80; GTF2H2C_2; ZFP830; GTF2H2
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
COPS7B; COPS2; COPS4; COPS6; ZFP830; PPIE; COPS8; GPS1; COPS3; ERCC8

Protein Function

COPS2 has several biochemical functions, for example, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS2 itself. We selected most functions COPS2 had, and list some proteins which have the same functions with COPS2. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein ITGA3; FAS; KRTAP13-3; HSPA5; LRRC4C; VCP; PDP1; C14orf93; KIF5C; DOCK10
Function signal transducer activity
Related Protein OLFR18; TAS2R110; OLFCG4; GHRHRL; GNB3; CSPG4; MUL1A; GNAV1; MRGPRH; APLNRA

Interacting Protein

COPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS2.
GFER; EP300; Dtl; COPS5; COPS3; Crebbp