cops4
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  • Official Full Name
  • COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
  • Background
  • This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
  • Synonyms
  • COPS4; COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 4; COP9 signalosome complex subunit 4; CSN4; SGN4; signalosome subunit 4; JAB1-containing signalosome subunit 4
Cat.#:COPS4-1704HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COPS4 Protein, GST-tagged
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Cat.#:COPS4-11461HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COPS4, GST-tagged
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Cat.#:COPS4-3781MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COPS4 Protein
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Cat.#:COPS4-1534RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COPS4 Protein
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Cat.#:COPS4-972RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COPS4 Protein, His-tagged
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Cat.#:COPS4-1587CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COPS4
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Cat.#:COPS4-11600ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COPS4
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Cat.#:COPS4-7357HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COPS4 293 Cell Lysate
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Involved Pathway

COPS4 involved in several pathways and played different roles in them. We selected most pathways COPS4 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
INO80B; PARP1; INO80C; NFRKB; COPS7B; ACTL6A; COPS5; YY1; GPS1; INO80E
DNA Repair
UIMC1; PPIE; RBBP8; RHNO1; KDM4A; USP10; COPS7A; INO80B; RNF4; TDP1
Formation of TC-NER Pre-Incision Complex
ZFP830; COPS6; ERCC8; ZNF830; DDB1; KIAA1530; COPS5; COPS7B; TCEA1; COPS4
Global Genome Nucleotide Excision Repair (GG-NER)
COPS4; INO80C; INO80B; COPS7A; COPS2; YY1; GPS1; PARP2; ACTR5; USP45
Nucleotide Excision Repair
CCNH; ERCC1; ZFP830; POLE4; GTF2H1; XPC; GTF2H3-2; GPS1; ERCC5; YY1A
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
COPS8; ZFP830; PPIE; COPS7A; GPS1; KIAA1530; COPS4; COPS2; COPS7B; ERCC8

Protein Function

COPS4 has several biochemical functions, for example, contributes_to NEDD8-specific protease activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS4 itself. We selected most functions COPS4 had, and list some proteins which have the same functions with COPS4. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to NEDD8-specific protease activity
Related Protein COPS4
Function protein binding
Related Protein FANCD2; KRTAP4-12; TMEM185A; RPRM; SPINK7; PPP2R4; DDO; RNF144B; XRCC6; GMPPA

Interacting Protein

COPS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS4.
USHBP1; Dtl; Ddb1; COPS5; CUL4B; FOS; C19orf57; vpr; ARF6; YWHAZ