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COPS4

  • Official Full Name

    COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)

  • Overview

    This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
  • Synonyms

    COPS4; COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 4; COP9 signalosome complex subunit 4; CSN4; SGN4; signalosome subunit 4; JAB1-containing signalosome subunit 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COPS4-11461H Recombinant Human COPS4, GST-tagged E.coli GST 1-250a.a.
Human COPS4-1704H Recombinant Human COPS4 Protein, GST-tagged Wheat Germ GST
Human COPS4-7357HCL Recombinant Human COPS4 293 Cell Lysate HEK293 N/A
Human COPS4-1956HF Recombinant Full Length Human COPS4 Protein, GST-tagged In Vitro Cell Free System GST 406 amino acids
Mouse COPS4-3781M Recombinant Mouse COPS4 Protein Mammalian Cell His
Mouse Cops4-2262M Recombinant Mouse Cops4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse COPS4-1888M Recombinant Mouse COPS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse COPS4-1888M-B Recombinant Mouse COPS4 Protein Pre-coupled Magnetic Beads HEK293
Rat COPS4-1534R Recombinant Rat COPS4 Protein Mammalian Cell His
Rat COPS4-1191R-B Recombinant Rat COPS4 Protein Pre-coupled Magnetic Beads HEK293
Rat COPS4-1191R Recombinant Rat COPS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque COPS4-972R Recombinant Rhesus monkey COPS4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque COPS4-797R-B Recombinant Rhesus Macaque COPS4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque COPS4-797R Recombinant Rhesus Macaque COPS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish COPS4-11600Z Recombinant Zebrafish COPS4 Mammalian Cell His
Chicken COPS4-1587C Recombinant Chicken COPS4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

COPS4 involved in several pathways and played different roles in them. We selected most pathways COPS4 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Damage Recognition in GG-NERDDB2;INO80E;COPS7A;PARP1;DDB1;NFRKB;CETN2;ACTL6A;YY1A
DNA RepairCOPS8;RAD51AP1;MGMT;DNA2;UIMC1;INO80C;COPS2;BRE;PNKP
Formation of TC-NER Pre-Incision ComplexZFP830;ZNF830;TCEA1;COPS2;PPIE;COPS3;COPS7B;ERCC8;COPS4
Global Genome Nucleotide Excision Repair (GG-NER)YY1;COPS3;PARP2;COPS6;ACTR5;ACTL6A;TFPT;COPS7B;GPS1
Nucleotide Excision RepairBIVM-ERCC5;RBX1;RFC3;ACTR5;POLE2;ERCC4;RFC5;MCRS1;RPA1
Transcription-Coupled Nucleotide Excision Repair (TC-NER)COPS4;ERCC8;ZFP830;COPS6;COPS8;ZNF830;COPS7A;KIAA1530;COPS3

COPS4 has several biochemical functions, for example, contributes_to NEDD8-specific protease activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS4 itself. We selected most functions COPS4 had, and list some proteins which have the same functions with COPS4. You can find most of the proteins on our site.

Function Related Protein
contributes_to NEDD8-specific protease activity
protein bindingERC2;EIF4E;MEGF6;HCLS1;MAGI1;DVL1;TIMM9;KIF3B;CD59

COPS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS4.

USHBP1; Dtl; Ddb1; COPS5; CUL4B; FOS; C19orf57; vpr; ARF6; YWHAZ

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