cops5
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  • Official Full Name
  • COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
  • Background
  • Jun activation domain-binding protein-1 (JAB1) also designated COP9 subunits 5 (COPS5) or SGN5 is a coactivator of AP-1 transcription factor that also promotes degradation of the cyclin-dependent kinase inhibitor p27Kip1. JAB1 interacts with c-Jun AP-1 containing complexes, and enhances transactivation from AP-1-dependent promoters. JAB1 is highly conserved in evolution and is widely expressed in mammalian tissues. It is localized both the nucleus and the cytoplasm.
  • Synonyms
  • COPS5; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; MOV 34; SGN5; 38 kDa Mov34 homolog; signalosome subunit 5; jun activation domain-binding protein 1; MOV-34; MGC3149
Cat.#:COPS5-1705HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COPS5 Protein, GST-tagged
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Cat.#:COPS5-29878THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COPS5, His-tagged
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Cat.#:COPS5-40HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human COPS5 protein, His-tagged
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Cat.#:COPS5-3782MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COPS5 Protein
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Cat.#:COPS5-973RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COPS5 Protein, His-tagged
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Cat.#:COPS5-3370CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COPS5
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Cat.#:COPS5-10989ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COPS5
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Cat.#:COPS5-7356HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COPS5 293 Cell Lysate
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Involved Pathway

COPS5 involved in several pathways and played different roles in them. We selected most pathways COPS5 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
PARP2; COPS7A; COPS5; COPS2; NFRKB; DDB1; INO80; ACTL6A; DDB2; GPS1
DNA Repair
RAD9A; CETN2; RNF111; RBBP8; COPS4; USP45; USP43; TCEA1; COPS5; RTEL1
Formation of TC-NER Pre-Incision Complex
COPS8; ZFP830; TCEA1; COPS3; GPS1; PPIE; COPS6; COPS5; KIAA1530; ERCC8
Global Genome Nucleotide Excision Repair (GG-NER)
ACTL6A; CHD1L; COPS7B; TFPT; ACTR5; COPS5; PIAS3; INO80B; COPS2; COPS4
HIF-1-alpha transcription factor network
ENG; COPS5; EGLN3; TFF3; GATA2; CITED2; CP; ADM; NDRG1; PLIN2
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
COPS5; HIF3A; HIF1AN; NAA10; GNB2L1
Nucleotide Excision Repair
GTF2H4; GTF2H1; RFC5; RPA3; CHD1L; POLE4; RAD23AB; GTF2H2C_2; POLE3; GTF2H3-2
TGF-beta Receptor Signaling Pathway
JUNBA; FOXH1; TGFBR3; ENG; ACVRL1; COPS5; EID2; NFYBB; STRAP; RUNX2A

Protein Function

COPS5 has several biochemical functions, for example, metal ion binding, metallopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS5 itself. We selected most functions COPS5 had, and list some proteins which have the same functions with COPS5. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein RNF17; NUBP1; MDP1; ZFP36L3; ZNF193; ZNF362A; SAR1B; ZNF501; HPDA; SLX1B
Function metallopeptidase activity
Related Protein GM12824; ADAM21; DNPEP; MMP2; MEP1A.1; NPEPPS; XPNPEP2; ADAMTS13; Npepo; ADAM28
Function protein binding
Related Protein CD177; PRKAB2; NACA; ZC3HC1; TAB1; STOX1; CFI; ZBTB8A; UBE2D2A; ARL13B
Function transcription coactivator activity
Related Protein JUND; CARM1; VGLL2; GTF2A2; MED14; IL31RA; TFDP1B; TADA1; MED12; SMARCE1
Function translation initiation factor activity
Related Protein EIF1B; COPS5; EIF4A1A; EIF4E2RS1; EIF3S6IP; AGO2; BRF1A; EIF4A2; EIF1AY; EIF4G2
Function ubiquitin-specific protease activity
Related Protein OTUD7B; USP25; USP42; USP28; ZRANB1B; UCHL1; OTUD4; EIF3F; OTUD5A; USP6

Interacting Protein

COPS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS5.
COPS3; GPS1; CUL4B; COPS6

COPS5 Related Articles

Rajan, KE; Rajkumar, R; et al. Light-induced COP9 signalosome expression in the Indian false vampire bat Megaderma lyra. JOURNAL OF PHYSIOLOGICAL SCIENCES 60:43-49(2010).
Oron, E; Mannervik, M; et al. COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. DEVELOPMENT 129:4399-4409(2002).