cox7b
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  • Official Full Name
  • cytochrome c oxidase subunit VIIb
  • Background
  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22.
  • Synonyms
  • COX7B; cytochrome c oxidase subunit VIIb; cytochrome c oxidase subunit 7B, mitochondrial; mitochondrial; COX7B_HUMAN; Cytochrome c oxidase chain VIIb; Cytochrome c oxidase polypeptide VIIb; Cytochrome c oxidase subunit 7B; Cytochrome c oxidase subunit 7B mitochondrial; cytochrome-c oxidase chain VIIb
Cat.#:COX7B-1763HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COX7B Protein, GST-tagged
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Cat.#:COX7B-119HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COX7B Protein, His-tagged
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Cat.#:COX7B-3825MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COX7B Protein
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Cat.#:COX7B-1557RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COX7B Protein
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Cat.#:COX7B-997RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COX7B Protein, His-tagged
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Cat.#:COX7B-7085ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COX7B
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Involved Pathway

COX7B involved in several pathways and played different roles in them. We selected most pathways COX7B participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX7B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
ATP5L; NDUFA4L; COX5A; NDUFA2; ATP6V1D; ATP4B; SDHDA; ATP5B; COX11; ATP5J
Metabolic pathways
ACSL1B; UQCRFS1; POLR2I; AGL; TPH2; B3GNT5B; MOCS1; CYP2C50; AK7B; ATP6V0D1
Cardiac muscle contraction
MYL2; TPM4A; CACNA1C; ATP1A2; COX6B2; ACTC1A; CACNB2A; TPM3; COX5A; TPM4B
Non-alcoholic fatty liver disease (NAFLD)
NDUFA9; PRKAB2; DDIT3; NDUFC2-KCTD14; MLXIPL; COX6A2; NDUFB10; LEPR; NDUFB3; INS1
Alzheimers disease
NDUFA13; Casp3; NDUFB6; NDUFS3; CAPN2; NDUFA4L2; MT-ATP6; COX7A2L; ADAM17; CALML3
Parkinsons disease
COX6B2; VDAC3; ATP5C1; HTRA2; SLC6A3; NDUFB7; MT-ATP6; MT-ND1; NDUFV1; COX7B
Huntingtons disease
DNAHC8; NDUFA4L2; BAX; DNAL4; NDUFA5; TP53; COX8A; CREB3L1; SDHC; POLR2C

Protein Function

COX7B has several biochemical functions, for example, cytochrome-c oxidase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by COX7B itself. We selected most functions COX7B had, and list some proteins which have the same functions with COX7B. You can find most of the proteins on our site.
Function
Related Protein
Function cytochrome-c oxidase activity
Related Protein COX7A2L; COX4I1; COX6A2; COX6B2; COX7C; COX6C; COX7B; COX7A2A; COX7A3; COX6B1
Function molecular_function
Related Protein DENND2DA; MIEF2; TEKT3; SPCS1; OTOL1; BCL7A; WBP1LB; AGPHD1; SSUH2.3; ITM2CB

COX7B Related Articles

Nijtmans, LGJ; Taanman, JW; et al. Assembly of cytochrome-c oxidase in cultured human cells. EUROPEAN JOURNAL OF BIOCHEMISTRY 254:389-394(1998).
Arnold, S; Lee, I; et al. The subunit structure of cytochrome-c oxidase from tuna heart and liver. EUROPEAN JOURNAL OF BIOCHEMISTRY 248:99-103(1997).