CPS1
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Official Full Name
carbamoyl-phosphate synthase 1, mitochondrial
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Overview
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate.;This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from;cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants;encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the;mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency,;susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow;transplantation. -
Synonyms
CPS1; carbamoyl-phosphate synthase 1, mitochondrial; carbamoyl phosphate synthetase 1, mitochondrial; carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoylphosphate synthetase I; CPSASE1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CPS1-1809H | Recombinant Human CPS1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | CPS1-1843H | Recombinant Human CPS1, His-tagged | E. coli | His |
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| Human | CPS1-0486H | Recombinant Human CPS1 protein, His-tagged | E.coli | His | 1354-1500aa |
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| Human | CPS1-5840H | Recombinant Human CPS1 protein, His-tagged | Yeast | His | 1354-1500aa |
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| Mouse | CPS1-3857M | Recombinant Mouse CPS1 Protein | Mammalian Cell | His |
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| Mouse | CPS1-1941M-B | Recombinant Mouse CPS1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | CPS1-1941M | Recombinant Mouse CPS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | CPS1-1573R | Recombinant Rat CPS1 Protein | Mammalian Cell | His |
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| Rat | CPS1-1230R | Recombinant Rat CPS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | Cps1-2724R | Recombinant Rat Cps1 protein, His&Myc-tagged | E.coli | His&Myc | 1355-1500aa |
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| Rat | CPS1-1230R-B | Recombinant Rat CPS1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | CPS1-3500C | Recombinant Chicken CPS1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- CPS1 Related Articles
CPS1 involved in several pathways and played different roles in them. We selected most pathways CPS1 participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine biosynthesis | ASS1;GLUL;NOS2;GLULB;ARG2;GLULA;GPT;ybaS;GLUD1 |
| Alanine, aspartate and glutamate metabolism | ABAT;GLUD1A;AGXTA;GAD2;ADSSL1;GAD1;GLULB;GLULC;DDO |
| Nitrogen metabolism | GLUL;CAR13;GLUD2;GLUD1A;Car14;CA14;CAR7;Car8;CA4A |
| Metabolic pathways | GALNT14;PGM3;BHMT;ALOX15;AGXT;ACLY;ACY1;ATIC;PDXK |
| Carbon metabolism | FBP1;SUCLG1;PKMB;pykF;SDS;GPIA;HAO2;PGP;CPS1 |
| Biosynthesis of amino acids | CS;PRPS1L1;TAT;ALDOAB;MAT2AA;PFKM;IDH3B;GM5506;ALDOCB |
CPS1 has several biochemical functions, for example, ATP binding, calcium ion binding, carbamoyl-phosphate synthase (ammonia) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CPS1 itself. We selected most functions CPS1 had, and list some proteins which have the same functions with CPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TTLL2;NARS2;NLRP12;QARS;WRNIP1;STK11;MAPK9;IDE;CAMK1G |
| calcium ion binding | THBD;PCDH2G10;EDEM1;PCDHGC5;DSC2;MMP8;EFCC1;THBS4B;GSNA |
| carbamoyl-phosphate synthase (ammonia) activity | CPS1;CAD |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | CAD;CPS1 |
| catalytic activity | PPM1NB;SCP2A;PKMB;PGAM1A;UQCRC2B;PNP5A;ECHDC3;GTF2F1;PHKB |
| endopeptidase activity | SENP3;ECE1;KLK1B11;KLK1B9;AP1S2;HTRA4;F9;PSMA2;APH1B |
| glutamate binding | GRIN2A;CPS1;GRM7;GCLC;GRIN1;GAD2;SLC1A3;SLC1A1;GRIK1 |
| ligase activity | DTX2;KCMF1;SHRPRBCK1R;SH3RF2;IRF2BP1;PIAS4;NEDD4;LIG4;RBX1 |
| metal ion binding | EFCAB5;NEURL3;RXRGA;CA;KLF5;ZBTB9;ZBTB2A;CYP2V1;ZNF831 |
| modified amino acid binding | NOX4;DPEP1;MUT;MTHFR;CPS1;CBS |
| nucleotide binding | STK25B;ABCB3L1;NLRP9B;AGAP2;RBFOX1L;SAFB2;EPHB2B;SLIRP;U2SURP |
| phospholipid binding | PLA2G2A;HIP1RB;WDFY4;NSFL1C;ABCG1;ESYT1;NR5A2;OTC;APOB |
| protein binding | PDIA6;GDPD5;KRR1;SWAP70;PROP1;PLRG1;TIRAP;RNH1;ACE |
| protein complex binding | LRRC16A;SKIL;MYSM1;RAP1A;NCKAP1L;VAMP2;RANBP2;MTAP1B;TRAF2 |
CPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPS1.
Sirt5; Amy1; Ywhae; Pgls; Hsd3b7
- Q&As
- Reviews
Q&As (7)
Ask a questionAltered TRIP13 activity is linked with cancer progression due to its role in cell cycle regulation.
TRIP13 works with other proteins to coordinate cell cycle progression and DNA repair processes.
Targeting TRIP13 could provide a novel approach in cancer treatment, focusing on its role in cell cycle regulation.
It assists in proper chromosome segregation, ensuring accurate cell division during mitosis.
TRIP13 is crucial for the regulation of the cell cycle, particularly in the transition between different phases.
Mutations in TRIP13 can lead to errors in cell division and increased genomic instability.
TRIP13 plays a role in DNA repair, contributing to genomic stability and integrity.
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