cps1
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  • Official Full Name
  • carbamoyl-phosphate synthase 1, mitochondrial
  • Background
  • The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate.;This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from;cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants;encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the;mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency,;susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow;transplantation.
  • Synonyms
  • CPS1; carbamoyl-phosphate synthase 1, mitochondrial; carbamoyl phosphate synthetase 1, mitochondrial; carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoylphosphate synthetase I; CPSASE1
Cat.#:CPS1-1809HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CPS1 Protein, GST-tagged
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Cat.#:CPS1-1843HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CPS1, His-tagged
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Cat.#:CPS1-3857MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CPS1 Protein
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Cat.#:CPS1-1573RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CPS1 Protein
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Cat.#:CPS1-3500CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CPS1
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Involved Pathway

CPS1 involved in several pathways and played different roles in them. We selected most pathways CPS1 participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine biosynthesis
GOT2A; NOS3; GLS2; GPT; GOT2B; NOS1; GOT1; ASL; GOT2; ASS1
Alanine, aspartate and glutamate metabolism
ADSSL1; GOT2B; GAD1; ASPA; ADSSL; RIMKLB; NAT8L; ABAT; GLUD1B; ASNS
Nitrogen metabolism
CA6; CA14; CA5A; CA5B; CA12; CAHZ; Car14; CA3; CA13; CA2
Metabolic pathways
CYP7A1; NDUFB7; AGXT2L2; GPAA1; GGT7; POLR2EB; C1GALT1; GAD1; AMPD1; PRODH
Carbon metabolism
ALDH6A1; SDHDA; H6PD; ME2; ALDOC; ACO2; PCCA; MDH2; PFKMA; CAT
Biosynthesis of amino acids
PRPS1L1; GM5506; CTH; ALDOB; PSPH; IDH3A; PYCRL; ASS1; PRPS1A; PRPS1

Protein Function

CPS1 has several biochemical functions, for example, ATP binding, calcium ion binding, carbamoyl-phosphate synthase (ammonia) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CPS1 itself. We selected most functions CPS1 had, and list some proteins which have the same functions with CPS1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RPS6KB2; EIF2B2; MAPK6; ACTB; MYH4; DTYMK; P2RX3B; ATP9A; SBK3; ABCD4
Function calcium ion binding
Related Protein ALOX15B; EFCAB1; PADI6; TNNC1A; PCDHA6; C1rb; RCN3; PCDH2AB12; MYL13; CRB2B
Function carbamoyl-phosphate synthase (ammonia) activity
Related Protein CPS1; CAD
Function carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Related Protein CAD; CPS1
Function catalytic activity
Related Protein SGSH; FHIT; APOBEC2A; PPM1AB; GMPR2; LDHBB; CDYL2; RAG1; NDUFA9A; PHYKPL
Function endopeptidase activity
Related Protein PSMB7; PSEN1; PSMB4; PSMB11; PSMA1; PSMB1; PSMA5; AP1S2; REN2; TPP2
Function glutamate binding
Related Protein GRIN1; SLC1A3; SLC1A1; GRM7; GRIK1; GLUL; GRIN2A; GAD2; GCLC; CPS1
Function ligase activity
Related Protein TRIM2; LTN1; TRIM24; PCXB; CPS1; KCMF1; UBR3; RNF146; PIAS1; RFWD2
Function metal ion binding
Related Protein KSR1; DNA2; TRIM35-31; CHN2; ZEB2; ANKIB1; PCK2; ZBTB25; PFAS; GNA14
Function modified amino acid binding
Related Protein MUT; DPEP1; CPS1; CBS; NOX4; MTHFR
Function nucleotide binding
Related Protein SRPK1B; HNRNPA1A; WRNIP1; FUS; RBM12B1; GKUP; EIF4BA; PHKG1A; NLRP9B; RAB11BA
Function phospholipid binding
Related Protein GLTPD1; SPTBN1; SEC14L2; PLA2G4C; LPAR3; APOEB; APOEA; NR5A1; DAPP1; NSMAF
Function protein binding
Related Protein PDP1; SERPINE2; ZBTB25; DPYSL4; DUSP13; MARVELD2; FRMD7; GLYCTK; PVRL2; ZFYVE19
Function protein complex binding
Related Protein ATF1; BAX; PTPRF; PTCH1; PPFIA2; PRMT5; ING2; TUBB; TG; CDK2

Interacting Protein

CPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPS1.
Sirt5; Amy1; Ywhae; Pgls; Hsd3b7

CPS1 Related Articles

Lee, YY; Li, CF; et al. Overexpression of CPS1 is an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy. TUMOR BIOLOGY 35:11097-11105(2014).
Li, J; Chen, L; et al. Detection of Circulating Tumor Cells in Hepatocellular Carcinoma Using Antibodies against Asialoglycoprotein Receptor, Carbamoyl Phosphate Synthetase 1 and Pan-Cytokeratin. PLOS ONE 9:-(2014).