creb3
Share
  • Official Full Name
  • cAMP responsive element binding protein 3
  • Background
  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
  • Synonyms
  • CREB3; cAMP responsive element binding protein 3; cAMP responsive element binding protein 3 (luman); cyclic AMP-responsive element-binding protein 3; Luman; LZIP; CREB-3; basic leucine zipper protein; transcription factor LZIP-alpha; cAMP-responsive eleme
Cat.#:CREB3-1842HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CREB3 Protein, GST-tagged
+Inquiry
Cat.#:CREB3-1020RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CREB3 Protein, His-tagged
+Inquiry
Cat.#:CREB3-396HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CREB3 cell lysate
+Inquiry

Involved Pathway

CREB3 involved in several pathways and played different roles in them. We selected most pathways CREB3 participated on our site, such as AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AMPK signaling pathway
PIK3CD; CCND1; GYS1; PPP2R5A; ADIPOR2; MLYCD; CPT1C; G6PC2; PPP2R1A; PRKAB2
Adrenergic signaling in cardiomyocytes
GNAIA; SCN4BA; CREB3L3A; CAMK2B; BCL2A; PIK3CA; MAPK1; PRKACA; PIK3R2; PPP2R5EB
Alcoholism
GRIN3B; CREB5; HDAC4; GM14483; PKIA; ATF2; HIST1H4N; CAMK4; HIST1H2AH; HIST1H4F
Aldosterone synthesis and secretion
Adcy4; CAMK2A; ADCY3; CACNA1G; CALM3; AKR1C1; CREB3; HSD3B1; CAMK2B; KCNK3
Amphetamine addiction
CALML3; CREB3L2; SIRT1; CAMK2G; DRD1; MAOB; ATF4; GRIA2; CREB3L3; GRIN2D
Cholinergic synapse
GNAI3; KCNJ6; KCNJ3; FYN; PIK3CB; CAMK2B; PLCB2; CHRM2; Adcy4; GNG13
Cocaine addiction
RGS9; SLC18A2; TH; CREB3L1; CREB3L2; MAOA; ATF4; GRM2; GNAI3; GNAS
Dopaminergic synapse
CALM1; PPP3CB; GRIA4; GNAS; PPP2R2C; GNG8; MAOA; GRIA3; CALY; PPP2R5E

Protein Function

CREB3 has several biochemical functions, for example, CCR1 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB3 itself. We selected most functions CREB3 had, and list some proteins which have the same functions with CREB3. You can find most of the proteins on our site.
Function
Related Protein
Function CCR1 chemokine receptor binding
Related Protein CCL7; CCL5; CCL23; CCL3; CREB3; CCL4
Function DNA binding
Related Protein HNF4A; HOXB3A; H1M; ENG2A; ZMAT2; SP9; SATB1A; POLR2F; H2AFX; H2BFWT
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein IRF4; ZNF253; ZNF114; IFI203; NR1D1; YBX1; POU4F3; NR4A3; PITX1; MYC
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein ZIK1; GATA2; H2AFY; NEUROD2; ESRRG; SP3; PURB; GATA1; RARA; CREB3
Function cAMP response element binding
Related Protein CREB3L1; HMGA2; CREB1; E4F1; CREB3L3A; CREB3; ATF6B; CREB3L3; CREB3L4; JUN
Function cAMP response element binding protein binding
Related Protein CREB3; CRTC2; CREM; KCNA3; CRTC1A; DDIT3; DAPK3; CRTC1; ATF2; CRTC3
Function chromatin binding
Related Protein EP300; ZKSCAN3; GATA5; POU1F1; TRP53; CNBPA; SKOR2; HMGB2B; YBX1; ARID3C
Function protein binding
Related Protein EIF2S2; MRPL9; FSHB; PMAIP1; GDI2; RIC8; GTF2H3; AIMP2; DNM1L; ASCC3
Function protein dimerization activity
Related Protein STAT3; HPSE; NPAS4A; MTOR; DAO1; BHLHE41; ATOH7; SCXA; HEY1; MXD1
Function protein homodimerization activity
Related Protein SRGAP2; MUC13; CDH13; PARK7; BLOC1S6; RABEP1; FGFR2; S100A10; ADRB3; CHEK2
Function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MSX1; IRF7; BATF2; MSX2; BATF; CLOCK; SREBF1; FOSL2; RBPJB; SNAI3
Function transcription factor activity, sequence-specific DNA binding
Related Protein CREB3L3L; TCEAL1; ZNF19; ZNF584; ZNF193; CIR1; RAB11FIP4A; RNF4; NKX2-1; ZNF217
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CTCFL; MTF1; NRL; SMAD1; PLAG1; ELF1; FOXK2; TFAP2C; NFATC3; FOSB

Interacting Protein

CREB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB3.
HCFC1; STX8; JUN; DDIT3; NFIL3; CREB3L3; BATF3; CREBZF; CREB3L4; 10431

CREB3 Related Articles

Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
Kawarabayashi, Y; Hai, L; et al. Critical Role of TRPC1-Mediated Ca2+ Entry in Decidualization of Human Endometrial Stromal Cells. MOLECULAR ENDOCRINOLOGY 26:846-858(2012).