crem
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  • Official Full Name
  • cAMP responsive element modulator
  • Background
  • This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
  • Synonyms
  • CREM; cAMP responsive element modulator; cAMP-responsive element modulator; hCREM 2; CREM 2beta-a protein; CREM 2alpha-b protein; cAMP response element modulator; inducible cAMP early repressor ICER; ICER; CREM-2; hCREM-2; MGC17881; MGC41893; MGC111110
Cat.#:CREM-1862HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CREM Protein, GST-tagged
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Cat.#:CREM-3330HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CREM Protein, His-tagged
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Cat.#:CREM-3900MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CREM Protein
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Cat.#:CREM-5384CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CREM
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Cat.#:CREM-5385CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CREM
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Cat.#:CREM-5386CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CREM
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Cat.#:CREM-5387CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CREM
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Cat.#:CREM-5957CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CREM
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Cat.#:CREM-7283HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CREM 293 Cell Lysate
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Cat.#:CREM-7284HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CREM 293 Cell Lysate
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Cat.#:CREM-7285HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CREM 293 Cell Lysate
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Involved Pathway

CREM involved in several pathways and played different roles in them. We selected most pathways CREM participated on our site, such as Adrenergic signaling in cardiomyocytes, HTLV-I infection, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adrenergic signaling in cardiomyocytes
MYL2; CAMK2D1; TNNC1B; CACNG7; PPP2R2D; ADRa1A; PPP2R5B; MAPK13; CACNB2; PIK3R3A
HTLV-I infection
DLG1; TBPL2; RRAS2; ANAPC4; SFPI1; HLA-DRB5; WNT9B; NFKB1; GM-CSF; MSX1
SIDS Susceptibility Pathways
POU2F2; KCNQ1; EN1; GATA2; MAZ; SCN3B; TPPP; LMX1B; DEAF1; PLP1
Selenium Metabolism and Selenoproteins
SELENBP1; DIO2; TXNRD3IT1; SELT; TRNAU1AP; MSRB1; TXNRD2; CREM; SP3; SELK

Protein Function

CREM has several biochemical functions, for example, DNA binding, cAMP response element binding protein binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREM itself. We selected most functions CREM had, and list some proteins which have the same functions with CREM. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein POLG; TBL1XR1; CDX1B; FOXA1; HIST2H3C; KHSRP; STRA13; DACH2; NFE2L2; SPHK1
Function cAMP response element binding protein binding
Related Protein KCNA3; CRTC2; CREB3; CRTC1A; CREM; ATF2; CRTC1; DAPK3; DDIT3; CRTC3
Function core promoter sequence-specific DNA binding
Related Protein CREM; RORA; THRAP3; ZNF750; NFYA; TRP53; NRIP1; CRY1; ZFHX3; MEOX1
Function protein binding
Related Protein RPN1; S100A4; PTPN12; PIN1; PPIG; DCLRE1B; AP1B1; PCNA; MZF1; TWSG1
Function transcription factor activity, sequence-specific DNA binding
Related Protein PBX4; HIVEP2; ZNF202; MYCL1; SPI1B; E2F5; NFKB2; PIP4K2AA; ZIC1; TBX5A

Interacting Protein

CREM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREM here. Most of them are supplied by our site. Hope this information will be useful for your research of CREM.
il2_human_gene; fos_human_gene; il2_human_crem-site_dna-probe; SP100; il17_human_cre-site_dna-probe; Hdac1; HDAC1; DNMT3A; ATXN1; EMP3; UBE2I

CREM Related Articles

Khajavi, N; Akbari, M; et al. Role of Somatic Testicular Cells during Mouse Spermatogenesis in Three-Dimensional Collagen Gel Culture System. CELL JOURNAL 16:79-90(2014).
Huang, YF; Kream, BE; et al. The P2 Promoter of the CREM Gene is Responsive to cAMP-PKA Signaling Pathway in Osteoblastic MC3T3-E1 Cells. JOURNAL OF HARD TISSUE BIOLOGY 20:225-230(2011).